ID   B3RTG7_TRIAD            Unreviewed;       704 AA.
AC   B3RTG7;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   ORFNames=TRIADDRAFT_22911 {ECO:0000313|EMBL:EDV26690.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV26690.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV26690.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV26690.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC       {ECO:0000256|ARBA:ARBA00006637}.
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DR   EMBL; DS985243; EDV26690.1; -; Genomic_DNA.
DR   RefSeq; XP_002110686.1; XM_002110650.1.
DR   AlphaFoldDB; B3RTG7; -.
DR   STRING; 10228.B3RTG7; -.
DR   EnsemblMetazoa; TriadT22911; TriadP22911; TriadG22911.
DR   GeneID; 6752434; -.
DR   KEGG; tad:TRIADDRAFT_22911; -.
DR   CTD; 6752434; -.
DR   eggNOG; KOG1123; Eukaryota.
DR   HOGENOM; CLU_008213_0_0_1; -.
DR   InParanoid; B3RTG7; -.
DR   OMA; RCQEIDY; -.
DR   OrthoDB; 1360679at2759; -.
DR   PhylomeDB; B3RTG7; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IBA:GO_Central.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR   GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IBA:GO_Central.
DR   CDD; cd18029; DEXHc_XPB; 1.
DR   CDD; cd18789; SF2_C_XPB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR032438; ERCC3_RAD25_C.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001161; XPB/Ssl2.
DR   InterPro; IPR032830; XPB/Ssl2_N.
DR   NCBIfam; TIGR00603; rad25; 1.
DR   PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR   PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR   Pfam; PF16203; ERCC3_RAD25_C; 1.
DR   Pfam; PF13625; Helicase_C_3; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   PRINTS; PR00851; XRODRMPGMNTB.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT   DOMAIN          251..412
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          468..628
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EDV26690.1"
SQ   SEQUENCE   704 AA;  81130 MW;  959348A065FDE0BC CRC64;
     DDYGAKDYRD VMQLKPDHRT RPLWVAPDGH IFLEAFSPVY KHAHDFLIAI SEPICRPEHV
     HEYKLTPYSL YAAVSVGLQT EDIIEYLRRL SKASIPDGVI EFIKLCTVSY GKVKMVLKHN
     RYYVESSHPE IIQMLLKDPV VQAARVKEGQ INDPSESDET LDPKEENIPS DIYDYLDKID
     RDEEDIEITK TISFEINSDD VELVQRRCIE MEYPLLAEYD FRNDTVNPDI SIDLRPTTIL
     RPYQEKSLRK MFGNGRARSG VIVLPCGAGK TLVGVTAACT VKKRCLVLCT SGVAVEQWKA
     QFKLWSTIDE SLISRFTSDA KDKPSGCSVA ISTYSMVAHT TKRSWESERV MEYLQGQEWG
     LMILDEVHTI PAKQFRRVLT VVHAHCKLGL TATLVREDDK IQDLNFLIGP KLYEANWMEL
     QSLNFIARVQ CAEACVWCPM SPEFYREYLT TKTRKHMLFY VMNPNKFRAC QFLIKYHERR
     NDKVIVFSDN VFGLKHYAIE LGKPYIYGPT AQKERLQILQ NFQHNPLVNC IFISKVGDNS
     FDLPEANVLI QISSHGGSRR QEAQRLGRIL RAKKDSATEE YNAYFYSLVS QDTQEMYFSS
     KRQRFLINQG YSFKVITKLS GMDDENLLYT EKKDQHQLLQ KVLAANETDA EEEKVAGDTY
     STSSKSQVVR RTTSMASLSG ADDLVYLEYN KPKQRHPLFK KFRK
//