ID B3RXX9_TRIAD Unreviewed; 3863 AA.
AC B3RXX9;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=TRIADDRAFT_25541 {ECO:0000313|EMBL:EDV24937.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV24937.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV24937.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV24937.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; DS985245; EDV24937.1; -; Genomic_DNA.
DR RefSeq; XP_002112827.1; XM_002112791.1.
DR STRING; 10228.B3RXX9; -.
DR EnsemblMetazoa; TriadT25541; TriadP25541; TriadG25541.
DR GeneID; 6753609; -.
DR KEGG; tad:TRIADDRAFT_25541; -.
DR CTD; 6753609; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_0_0_1; -.
DR InParanoid; B3RXX9; -.
DR OMA; CIEWQRY; -.
DR OrthoDB; 166463at2759; -.
DR PhylomeDB; B3RXX9; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0036156; C:inner dynein arm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 1171..1274
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1452..1605
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1802..1950
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 539..566
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2463..2504
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2647..2698
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV24937.1"
SQ SEQUENCE 3863 AA; 441458 MW; A90637F3D1E6CBCC CRC64;
LNYQYLRAQV RSSPVSGMVG TWWNNIYSKI PEPLLRSKPL SSRRDVICQE IEDIYMSSLQ
KSMAQYVLLK PHIKLVEGED QRKADPTGLD FSTPWKKNFE DARRKLISDL HILHPAMLKI
LCLSQKFRDQ EIVNFKNIRD KGPNELGDLK NDIVIDCERT EEKILNKWFP EILNIFSDRK
LFAEVTGSKA DSFFSSVSIL ISNLMKNYIN RTIGEWVALF DQDINLTKMP QFNLSLTLEN
NELIFYPSRE ELEAALLGVV TTVANTLQKI PTVQSWLNGN SNIFHDTCVD ASVLGEANKR
LLSVVENSFN ELYGYLNIYD PYRFLVDGTA ETEVVTFLSG EHSFEEYCTK VGRFRSLAKE
IMGLPNWAHF AMVRLDCEEI KFCLADIARS YANRLMRKLS EDHRQENLRI CHEYEEIQRR
ASAVPQSTKD MIDSINYITD AKALKLFQLN EKIKSSFHRL LYLLEASLLC SDDIELNSIT
LTWPQRIDPV FEENDDIIAT ARKNSERNLV DKREKVLLDL EKLNRRVMEY NEYGDLDMMN
QYVKDVQSTQ RKIQEISEMI SVINEEEQLL QWESTYYPEI EHLSNTLEPF SKLFTLAVRW
QKSEKKWTDG SFLDLIAETV ENEVNEYNRD ILKVAKVFTA RLKKGKGKEA TRQKKGERLS
DREIKDEETP AIKVSNAIQK QILDFKVHIP LVTTLCNPGI RDRHWKQMSQ FIGFDLTPDS
GTTLRKVLKI NLQPYMEEFE NISLAASKEF ALEKSLQRMV EEWDAVNFNT TTYRDSGIVI
LAAIDDIQTL LDDQIIKTQI MKGSPFIKPF EKDIKEWEER LTRVQDIIDE WLKVQAQWLY
LEPIFSSEDI MLQMPEEGRL FQTVDRTWKD VMKNALKDPK VLAATSMANL LERLTDCNRL
LEKINKGLNQ YLEKKRLYFP RFFFLSNDEI LEILSETKDP TRVQPHLKKC FEGISELDFT
NNMNITAMYS AQGEKIDFTE RISTSETKGA VEKWLLRVQN VMFLSVKNVL DKALEAYTDD
ERSIWVTEWP GQVVLTVNQI IWTRETHDAI KLGPHGLNDY HDRLQRQLEN IVKLVRGELS
KQTRITLGAL VVIDVHARDV ILELADKGVS SESDFQWLCQ LRYYWHLDDI TIRIVNASVN
YGYEYLGNTS RLVITPLTDR CYRTLVSAYS LNLNGAPEGP AGTGKTETVK DLAKALAKQC
VVFNCSDGLD YLAMGKFFKG LASSGAWACF DEFNRIELEV LSVVAQQILA IQRAVQSQLD
RFVFDGTEIV LNPSCYVCIT MNPGYAGRSE LPDNLKVLFR TVAMMVPDYA LISEIMLYSY
GFVDARNLAI KIVSTYRLCS ELLSTQFHYD YGMRAVKAVL AAAANLKLKH PSENESVLLL
RSIIDVNSPK FLAHDIPLFE GIVSDLFPNI NLPKPNYAYL IDAAKEICTG KNLQFVEFFK
QKLIQTYEMM IVRHGFMLVG GPLAGKTKVL EILAETLASL HQKGFDEDKV QYRIINPKAI
TMGQLFGQFD PVSHEWTDGV IATTFREFAH SSKTRNWVVF DGPVDTLWIE SMNTALDDNK
KLCLMSGEII QMSDKMSLIF ECLDLSQASP ATVSRCGMIY LEPASLGWEL LLLSWLEELP
GGLQDACPYI LALMKWMATA CLDFIYRNCK QLEHTSSSSL VMSFLKLTKA LILPYGEELV
SENKHKRTWI TASIIFACVW SVGGSVDGES RTKFDIFLRE LLSGKVSTYP IPDILGRIDV
PLPETGLLYD YVYENKGRGR WLPWLDSKNG ITIPLDAKMN EIIVPTTDTM RYSYLLDLLI
QYGLPILLVG PTGTGKTMYV KEKLIHKLPR DRYSPVLINF SAQTTANQTQ DIVMSKLDKR
RKGIYGPPLG KNCILFVDDL NMPMQEKYGA QPPIELLRQW LDHKIWYDRK DTSKIQLDDI
QIIGAMGPPG GGRSHISSRF LRHFNIISMT IFSDEAMLTI FNTIVTHILK VRQFPAEYFS
VGMQVVAATL QIYKSAIGNL LPTPAKSHYT FNLRDFSRTI QGVLLVRPQS IENKRSLIRL
WVHEIYRVFY DRLTDINDRD WLYNLTKKVV REHLKDNFDD IFSHLAVKEG EAPTEDDMRK
LLFGDYMASD SETDDQLYEE VTSLEDMNNV VELKLEDYNM THKTPMKLVV FSYMLEHLSR
ICRVLKQAGG NLLLVGVGGS GRQSLTSLAA FMSGFNVFQP EISKNYGRSE WKDDLKKLLK
GAGCQGKPTV FLLGDSQIKD ESFLEDIDSL LNSSEVPNLF PPDEKAELIE AIRPVAQAKD
VNAEFTPLTL YNYFIGRCRD NLHIALCMSP IGDAFRTRIR RFPSLINCCN IDWYQAWPED
ALEMVAYKFL EDIDLQENER DNIVDLCKLF HKNIRQLSQK YLAELNRHNY VTPTSYLELI
SSFKLLLSQK RNEIIKVSKR YEGGLQKLAF ASEQVASMQI ELENLQPQLV RASEQNSEMM
TLIENESKEV EAASNIVREE EHKANEQAAE AQALKDECEN DLAEAIPALE AAQAALDTLR
PADIAIVRTM VNPPPGVKLV LAAVCVMRGI KADKVNNPDK PNEKILDYWG PSKKMLTDMN
FLNTLKIYDK DNIQPQTMDR IRSEFLRNEN FDPAKVRTAS SAAEGLCKWV IAMEIYDRVA
KIVAPKKIRL REAEEKLSQI MAALNEKRSE LRAIESKFTS LQNQLEAGQE KKAQLEFQVD
LCAKKLERAT KLIGGLGGEN DRWRSAVKAL EEVYNNLVGD VLISAGTIAY LGPFTSSYRS
VCVAGWNSRC KESQVPCSAE FSLSKTLGEP IKIRTWNIAG LPNDSFSIDN GIIVANARRW
PLMIDPQSQA NKWIKTLERD NNLAIIKLSD PDYMRALENS IQFGNPVLLE NISEEIDPSL
EPILLKQAFK QGGIQYMRLG ENIVQYSTDF RLYITTKLRN PHYLPEVATK VSLLNFMITP
EGLEDQLLGL VVAREKPELE EQRNALIVQS ATNKKQLKEI EDKILETLSS SEGNILEDES
AIQVLDSSKS LSDEITKKQK IAEETEEKIN QSRAGYRPIA KHSSVLYFSI TDLANIDPMY
QYSLSWFVNL YINSITESNK SKILEKRLRY LTDHFTYNLY SNVCRSLFEK DKLLFSFLLC
CNMLTARSEM DSDEFMFFLT GGVGLENKLQ NPAPQWLPDR AWDEICRMSE LQSLQSFRES
FVGGIDDWRL MYESKEPYKM PLPSPCNEKL NDFQRMMVVR CLRPDKVIPT ILAFVEEKLG
RKFVDPPPFD LYKSYADSSC VAPLLFILSP GADPMAGLMK FAEDKGFIGN RFNAISLGQG
QGPIAAKLIN VASKEGNWVV LQNCHLAVSW LPTLERICEK LLADKVDQNF RLWLTSYPSD
KFPIPILQNS IKMTNEPPTG LRQNLLQSYS NDPISDPNFF GKCRGKEQAF SKLLYGLCFF
HALVQERRKF GPIGWNIPYG FNESDLRISI RQLQTFVGDY DQIPFDALLY LTGECNYGGR
VTDEWDRRCL LTLLSDFYCS EIVNDSKYKL SPSGIYIVLS SGNLDNYIED IKNLPMHQQP
EVFGLHENVD ISRELRETKL IFESLLSTQG SNVATGVSRK ADDTLYDIAQ DVMTKLPSNF
DLAGAIKKYP VSYSESMNTV LVQELKRFND LLEAIRSSLS NLQKAIKGLV IMSTDLESLS
QSLLIGKVVP ELWMKFSYPS LKPLGSYIAD LLMRLKFLKD WFNKGEPVVY WLSGFFFTQA
FLTGVIQNYA RKYTIAIDKL NFSYEVLSQN HDEITNSPTD GAYIYGVYLE GARWDRDRRV
VTESYPKLLY DLLPVIYLKP GIIGEVLTLP MYDCPVYKTS ARRGTLSTTG HSTNYVLTIK
LPTEKPAKHW IKRGVALLCQ LDD
//
