ID B3RYJ6_TRIAD Unreviewed; 688 AA.
AC B3RYJ6;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=J domain-containing protein {ECO:0000259|PROSITE:PS50076};
GN ORFNames=TRIADDRAFT_56581 {ECO:0000313|EMBL:EDV24609.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV24609.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV24609.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV24609.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS985245; EDV24609.1; -; Genomic_DNA.
DR RefSeq; XP_002112499.1; XM_002112463.1.
DR AlphaFoldDB; B3RYJ6; -.
DR STRING; 10228.B3RYJ6; -.
DR EnsemblMetazoa; TriadT56581; TriadP56581; TriadG56581.
DR GeneID; 6754154; -.
DR KEGG; tad:TRIADDRAFT_56581; -.
DR CTD; 6754154; -.
DR eggNOG; KOG0721; Eukaryota.
DR HOGENOM; CLU_014210_1_0_1; -.
DR InParanoid; B3RYJ6; -.
DR OMA; RAILHAH; -.
DR OrthoDB; 1605at2759; -.
DR PhylomeDB; B3RYJ6; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0031207; C:Sec62/Sec63 complex; IBA:GO_Central.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006620; P:post-translational protein targeting to endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR004179; Sec63-dom.
DR PANTHER; PTHR24075; SEC63 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24075:SF0; TRANSLOCATION PROTEIN SEC63 HOMOLOG; 1.
DR Pfam; PF00226; DnaJ; 1.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..165
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 441..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..493
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..527
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..688
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 79375 MW; 81A5205BA4494693 CRC64;
MAGAKFTYDE SGNTFYYFAT SFYLMILIPL TYYYRPKKEK KDSTQDDSND CQCHGCIDKR
AFLKKTSHKK SNRKIYIILV IAWIIAAIIV YKVSSMKNEA VAFDPYEILK ISEGAMQAQI
RAAYRTLSKI HHPDRGGDPK KFIMISRAYK ALANEESRKM WEEFGDPDGP REIKFGIALP
SWIVEKNNSW MIVAFYFIVF LGLPPVGLYF WWRRAVKYGG DKVYSDTVKL FTYQVHKTHT
LATSRALMVL SAAFEFCGKM NPDIKERESD NEDLSKLVSK LGSEVKIGCK EQLLGAPYSV
KTRALLLAHM QKMELPSKNL KNEGQVRNVF SSIENILKLS QCLIQCTWGD LHPMLQIPHL
KREMLRHFQT KKRSIRTITD LVALPAEDRR SLLRTLTDQD YNDAMKFCAN LPYLSITVDT
KVVTRYQTIV LQELFHEANK EKSLSEEIEN IGPDDENEKK DRNAPMQNHN SRKKQGKNKK
SQKFQKGKKP AQKKITKKVE EISTVQDEES ENDNADDEEE NKSDAEYNSD DDDVVANGKD
EWEVKMEKRH KEYLYGDTVP TSPLVHCPYF PEERRESWFV YLADKKHSQF LTERTFSFVD
DLVDTKELTF QFPAPPNIGS YGFCVVVRSD CYLDVDKRVY HTINVEAPKE SHIAEVSDLE
SETESESEDN GEDVTDSGSD DWDNEAEE
//
