ID B3S3W2_TRIAD Unreviewed; 818 AA.
AC B3S3W2;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Extracellular Endonuclease subunit A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRIADDRAFT_58867 {ECO:0000313|EMBL:EDV22537.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV22537.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV22537.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV22537.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
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DR EMBL; DS985249; EDV22537.1; -; Genomic_DNA.
DR RefSeq; XP_002115081.1; XM_002115045.1.
DR AlphaFoldDB; B3S3W2; -.
DR STRING; 10228.B3S3W2; -.
DR EnsemblMetazoa; TriadT58867; TriadP58867; TriadG58867.
DR GeneID; 6756293; -.
DR KEGG; tad:TRIADDRAFT_58867; -.
DR CTD; 6756293; -.
DR eggNOG; KOG2645; Eukaryota.
DR HOGENOM; CLU_012256_0_1_1; -.
DR InParanoid; B3S3W2; -.
DR OMA; MIPTHYF; -.
DR OrthoDB; 1366859at2759; -.
DR PhylomeDB; B3S3W2; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 3.30.1360.180; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF114; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 571..801
FT /note="DNA/RNA non-specific endonuclease"
FT /evidence="ECO:0000259|SMART:SM00892"
FT DOMAIN 572..801
FT /note="Extracellular Endonuclease subunit A"
FT /evidence="ECO:0000259|SMART:SM00477"
FT REGION 86..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 92982 MW; 2E7D4A5764DEEB7D CRC64;
MPDNMVISQL MILIYKYVIV FPNYFELLEQ QVDKNGNIEE YEKKYRLRNR RKTAFMMVLS
ALALLLAFTG GFVIGWFSSD KGFDQSNQGN NNSNNNSSNQ FTASPPRSTI PVNSGPPSID
ASICSAKRKP LIVVSVDGFR WDYFKRGLSP MLTQFASRGV RAEYMQSCFP TKTFPNHYTI
VTGLYPAHHG IVANTFYDPE LGETFYIGSR NNNQSKWWGG EPIWVTAKKN NLKSASFYWA
GSEAKIQGYR PDYWFPYDRS VSFIDRVNQL FKWLEMPADR RPMIITMYFD QPDRVGHLYG
PDSNQVDYEI KRVDDILGAI FSGLKERGLE DCVNIIVTSD HGMRKTCCKR VVYLDQLIDI
GHYNIINRGP FGGIRIHGGN ATELVQKLKC KFKHWSVYKK EELPYRLHYC NNSRIPDVII
MPNENWLVGS TYNPADTSCN GANHGWDNLD PDMRTIFFAA GPGFKKSLTI KPFKNIELYN
IMAALLSIKP AKNDGTIGRL NFILQNSTAA ATQIAGQLGS VCRVPQDHNV YIDRENCSDC
VCPDCKKESE NRNFPWGIPR YRASLDTCTL YQNHYITGYS NTFHVPLFVG YHLTDTESLR
PLSRIDCFRR DSRLNVAAQT SNCSNYYRSG YNRGHLAPNG DMSFDLEAQA NTFILSNIAP
QVYAFNAGPW LDLEKLTRDW ARLFGSIYVI SGSIVKADWK TVVGNPSYWL KGDIGSVVIP
THFYKILAKC QDSDQLLCDS SVMTAKPCKG KIDVIAFILP HIKSFAPQCQ TYNSYLFSHV
ASVRDIEELT GINFFPNMAP DLQDRIESEA ATEMWTTF
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