ID   B3S4E7_TRIAD            Unreviewed;      2366 AA.
AC   B3S4E7;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN   ORFNames=TRIADDRAFT_59057 {ECO:0000313|EMBL:EDV22626.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV22626.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV22626.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV22626.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
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DR   EMBL; DS985249; EDV22626.1; -; Genomic_DNA.
DR   RefSeq; XP_002115170.1; XM_002115134.1.
DR   STRING; 10228.B3S4E7; -.
DR   EnsemblMetazoa; TriadT59057; TriadP59057; TriadG59057.
DR   GeneID; 6756382; -.
DR   KEGG; tad:TRIADDRAFT_59057; -.
DR   CTD; 6756382; -.
DR   eggNOG; KOG1826; Eukaryota.
DR   HOGENOM; CLU_000249_0_0_1; -.
DR   InParanoid; B3S4E7; -.
DR   OMA; TKEPYMF; -.
DR   OrthoDB; 1356198at2759; -.
DR   PhylomeDB; B3S4E7; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   CDD; cd05130; RasGAP_Neurofibromin; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT   DOMAIN          1097..1291
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
SQ   SEQUENCE   2366 AA;  269009 MW;  0E5DBDC30AF1654B CRC64;
     MAIIPQCNEW VQAIIDRFDK QLPYNVGKVN SQAKISAEQN RRCLLTVSRN ELKRVISGLT
     TTLRNILLNS EIVKENPNSN IDLEDINESK SITLNTLEEC FKVNQDSTLD RELIEALLQT
     LAQITARSRD SKPSSREAAG RIILQISNKY WTTVFKHVSS SIQWLSRGTD DHADTCGIEL
     TQYLSLSITR IILLFKESRC FMSLKRTPQQ VLSDSISKGV WNWLRNNPKE FSQLYRDRNP
     ELADVSLVLF DKMEEYADSI KKKIVVWPLQ TLLLALAPDA VIENTKLKAS RKYKSLAGNK
     QLAEGAAIAC ADLCKIVNYL DADVKANIIL AAAKIITDLK QMFLNPQKPF GRIIGSSTGS
     ASTLEIQIIS DVFLASFRTK SLSIQYIEQC LLPTAPTNLH LAIVRGLKAI VTENSMAWWP
     PASSLYVLAS DLRIVFREAL TRMLQTERRK QTFSKNKDKK QKIEESNRDR DLVLSLILLF
     DDDPALALNT LRHFHQLENV LYLDTANWTS TLWNFNSLVV LTLSGKLVER VLECDVLQLA
     MWLREILTFR GRLLGKYKDD RMIVKSSMFT VTLQKLETAL LSCLWNSNIE TVLTALSCLR
     YLHKEAEYQL STLDDSNQLP LCFVNYQELA SLADELITGR AAIQKRIGAI LIKVEDHTEG
     NFQAWKEALK CWQKSTNHLL RQLKEESGLY DFLAMKRRSG SSYAPTQDDF NEWANVTGFL
     CSFGGIVVSN ANQILLRSGN KQKERERDSL AYARKFIIAL LNLLDCNNDQ FGAQIRGTLK
     EIIGQNMSPL LHPILFEQIE ELLSTFFPQN KQAIILESNT LFADQIISII RGILNKGSDE
     QLYSYLRNIN IETIMLYLIR YIRNLPMTAH TVPIKKRLCQ LVQNVMKRKD ALTFTQQIKF
     RNKLVSYLTE WVMNVSGSSS DVSSEIKGML RDLDLACMQA IAVLLADLPL QPDETEPNTN
     DTKIKIYLKY FTLFMNLLNE CSLLHQGSPR KQERLLSDYY LLLHDCTVAA MSNLLQANID
     YGLTLSLGLG YHSDLQTRTI FTEILTKILR EGTEFDTLAE TASSDRFEKF INLFMTTLKD
     SKLPLVLALI NGVSHSQLDE LCQALIPLSE AKSELDTLLL NVFGREVTSS DDVNTLFRGN
     TVASKMMTFC CNTFGKEYLV SIIDKVLDYI CSSDRVDHSY EVDPTRINGE ENVETNSVNL
     INLAKNVLNI ILSSAHMLPS QLKSACHCLY EVAESRFPQS GLSAVSNAIF LRFLNPAIVS
     PLSIGSKKRE ISLKSVRGLK LASKILQNCA NQVLFAKEHH MLPFNDFLTN HFNAIKEFLL
     NISSEKGNKV GDKADLAFVN DSLIYSLYSI VFDNQEQITQ YFAANRGSRC NKSRELLDQL
     SILLAQLGPP KKQFKQSYEI QRTQSTETES GSLFYEFMAK HKHYNEQEME IIKDANFFYL
     EGKSRKKYPV FYYICNNLCC EQMNEELVIY YIMSSLAPYM NKPWELVIDC TKFGPPNQLK
     GNFISKWFHV FPNQATDNLQ AVYIYNCNKW VRNYVKYHER VFQRVKGNEK IIVIDELTKI
     YEYIEENELK LPSATTSLQK DNKLFSNIAQ KVRVPSLYLP SLAFLIGPSS LQIRSAEKVK
     LLGFATTLND VFLASEIEEI SLRNENTFTL KCTNYGLNMA FISGEAEQIV NAISLIKHRW
     QLSQPNSINV YKKITPNEVP GTLLNMALLN LGNNDSKLRS SAYNLLCALA TAFNLPLEGQ
     LLETRGLRIP ANNLIFIVSI SQHLAKCEPF LTLQFLEESI DSFAKSKIEL KHLCLQYMSP
     WLPNLARFIT TGITERQKVI VIIEKLIDLT IKEKEMNSSV QAAIWEKMGQ VRELIDLVLD
     CFIQASGQRG LDSPNAEVMA NATVALAAAN LEIVSNKIIE RISQSLCTCR NLTLTDETLE
     LLRHRLEELS SARHCHLFGI SLRSEERMSL NALESITDLL VEVMNACNRD LPNLSWLDTW
     ITLASKFVVY HKSYSWTRRD LLGLFIFRKL ELETTPAIIL ARNFSTTGES SLYASGLGLL
     EESIYALDSQ EIFTNQVLHI PVLKMRLPIL EECGRFDNFT KCNFESNFHF AMVAILLKGR
     HHPSPETCAQ SIRLLDTLLH LINRSKECGK YDVNEESTAY LAALYPLVDE IPQKLARKSL
     DASSTSLFSA DNSGGFLWNK LLDPSLSEKT KVLLLCTLGI HFHYIHDEPK LRILSEIIEE
     ASRVMPLSFP ILGHIIDQKV GSILAHNRDL YILGYVQSIV QFMLTTKADY RNIISSDYLQ
     EIGFDGYFKF AGPFDQDEDI DRQTNWFHLF TKLCQAFLRT YEGVYKGMIP GVNFESRRGD
     RRATQKSGTS NPAFVTVFIE YPSHGQ
//