ID B3S744_TRIAD Unreviewed; 484 AA.
AC B3S744;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=TRIADDRAFT_60035 {ECO:0000313|EMBL:EDV21508.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV21508.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV21508.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV21508.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
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DR EMBL; DS985253; EDV21508.1; -; Genomic_DNA.
DR RefSeq; XP_002116108.1; XM_002116072.1.
DR AlphaFoldDB; B3S744; -.
DR STRING; 10228.B3S744; -.
DR EnsemblMetazoa; TriadT60035; TriadP60035; TriadG60035.
DR GeneID; 6757321; -.
DR KEGG; tad:TRIADDRAFT_60035; -.
DR CTD; 6757321; -.
DR eggNOG; KOG3521; Eukaryota.
DR HOGENOM; CLU_564224_0_0_1; -.
DR InParanoid; B3S744; -.
DR OrthoDB; 2873655at2759; -.
DR PhylomeDB; B3S744; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR040181; PKHG5/7.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR PANTHER; PTHR13217:SF6; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 261..436
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 28..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 56067 MW; FCEDA3646EBA38CC CRC64;
MEGFIHGLKS IERKNHYKVS GTAPTIYVTP PSDTEEESIE RARAQSLEAS RRHNKKEEKL
STSFLKFRYR TATKFLSPQR QSSEGNSNDD QDAVDGLQKF HYKEPLPWSM RAKRRHAQRK
RTRSLPITAR ENGKNYASLK KEDGESCRLN RSLASIKTST IEEDLTKEDI INGNGITSPE
KDGKTTVKTL FRRFKMIGNN NNLKAQKRED SPSIESFFTG LNQIDHEHDM AKYLEHDWTE
FFLNSESSET NKSCINIQEW KRRTSVWELF HSECVYLIDH LLILKDIFLM PLRLLQEYGF
LTEIDGFKLF GNIEELCALS SKFCTDLLLV FQSAQEDNLC STAAVVDTFT DKAINYFKSI
KDSDVFQEYL KHCQQNTSCR KLKLTDLLIA PIQRLTKYPL ILKEIIHYSQ EDDNGCKALS
SAITAVQVSL VELEEKVQKN LRIELMEELE NQIFWPKWEE FTPKAFIPEI VPALMKATYF
FSSI
//
