ID B3S7Q1_TRIAD Unreviewed; 303 AA.
AC B3S7Q1;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Ribonuclease H2 subunit B {ECO:0000256|ARBA:ARBA00019062};
DE AltName: Full=Ribonuclease HI subunit B {ECO:0000256|ARBA:ARBA00033464};
GN ORFNames=TRIADDRAFT_60250 {ECO:0000313|EMBL:EDV21233.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV21233.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV21233.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV21233.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC replication, possibly by mediating the removal of lagging-strand
CC Okazaki fragment RNA primers during DNA replication. Mediates the
CC excision of single ribonucleotides from DNA:RNA duplexes.
CC {ECO:0000256|ARBA:ARBA00024778}.
CC -!- SUBUNIT: The RNase H2 complex is a heterotrimer composed of the
CC catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and
CC RNASEH2C. {ECO:0000256|ARBA:ARBA00011277}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNase H2 subunit B family.
CC {ECO:0000256|ARBA:ARBA00009823}.
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DR EMBL; DS985254; EDV21233.1; -; Genomic_DNA.
DR RefSeq; XP_002116200.1; XM_002116164.1.
DR AlphaFoldDB; B3S7Q1; -.
DR STRING; 10228.B3S7Q1; -.
DR EnsemblMetazoa; TriadT60250; TriadP60250; TriadG60250.
DR GeneID; 6757513; -.
DR KEGG; tad:TRIADDRAFT_60250; -.
DR CTD; 6757513; -.
DR eggNOG; KOG4705; Eukaryota.
DR HOGENOM; CLU_059802_0_0_1; -.
DR InParanoid; B3S7Q1; -.
DR OMA; AQWVLIA; -.
DR OrthoDB; 38794at2759; -.
DR PhylomeDB; B3S7Q1; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0032299; C:ribonuclease H2 complex; IBA:GO_Central.
DR GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR CDD; cd09270; RNase_H2-B; 1.
DR Gene3D; 1.10.20.120; -; 1.
DR Gene3D; 2.20.25.530; -; 1.
DR InterPro; IPR040456; RNase_H2_suB.
DR InterPro; IPR019024; RNase_H2_suB_wHTH.
DR InterPro; IPR041195; Rnh202_N.
DR PANTHER; PTHR13383; RIBONUCLEASE H2 SUBUNIT B; 1.
DR PANTHER; PTHR13383:SF11; RIBONUCLEASE H2 SUBUNIT B; 1.
DR Pfam; PF09468; RNase_H2-Ydr279; 1.
DR Pfam; PF17745; Ydr279_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 18..88
FT /note="Rnh202 triple barrel"
FT /evidence="ECO:0000259|Pfam:PF17745"
FT DOMAIN 91..217
FT /note="Ribonuclease H2 subunit B wHTH"
FT /evidence="ECO:0000259|Pfam:PF09468"
FT REGION 229..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 303 AA; 34328 MW; 895C3795F480C92C CRC64;
MASAANQNKC PQNQWVAILP AAIANTNGSK NRIITLRHPR FDIGCQFLLC QESHSLFEIM
EFKEEPRSWF VNNTVQQNGA LLISTPVDPI FMILPYLAKV KDKFIPMDQI LMDDKFPSCS
RLYDCVSAND LAKVCECKGS EDLFAYRLST DKLIGWIQRK IERVADDLRH LGVYAGTGSQ
SETFTRSSKD SSTSKDDYIK YTFGLISDYL SKDICALVEK KMNITSQKIE MPPSKKLKQE
TKSQGPTDDY TKFNPPSTLA AQVQSSHDDK ARKLTSSERK LKKVDKTNIK SISSYFFRDK
KAS
//
