ID B3SBI4_TRIAD Unreviewed; 396 AA.
AC B3SBI4;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=TRIADDRAFT_61628 {ECO:0000313|EMBL:EDV19859.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV19859.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV19859.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV19859.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; DS985265; EDV19859.1; -; Genomic_DNA.
DR RefSeq; XP_002117601.1; XM_002117565.1.
DR AlphaFoldDB; B3SBI4; -.
DR STRING; 10228.B3SBI4; -.
DR EnsemblMetazoa; TriadT61628; TriadP61628; TriadG61628.
DR GeneID; 6758814; -.
DR KEGG; tad:TRIADDRAFT_61628; -.
DR CTD; 6758814; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_2_1; -.
DR InParanoid; B3SBI4; -.
DR OMA; EREAWKM; -.
DR OrthoDB; 1694166at2759; -.
DR PhylomeDB; B3SBI4; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd05227; AR_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF564; 3BETA_HSD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..396
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002797590"
FT DOMAIN 90..229
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 396 AA; 43897 MW; BB246A5812AEB26E CRC64;
MCLCLNTCVL ATNGCTVAVM ICTPTSKSCP KLRVLIIVFG DQILYLIKSS SNLSEASGYR
VRGSVRSLTN EKKVKPLKEL CPNAKFPLQL IEADLLVEET WHAAVQDCKY VMHVASPLPL
GKPRNEEEEL IKPAVNGTLN VLKACAKAGC VKRVVMTSTV GAIIGGMNGE NGRVYNEKDW
ADIETTEPYC KSKTLAEKAA WEFIENCSDN EKFEFCTINP CVTVGPVLHN TPFLSMQTAL
KLFDGSMPVL PNFNFPLCDV RDVAAAHLKA MIVPEAVGQR HIIYNSNMWY KDISLLYVRE
FGPYGYKFPT MVAPKFVLWL ASLFDPTLKL IIPFLNITTI FDNTRMKEVL NVPPRDISQA
IIDLGYSLIE RDVVKKTTGY TGPPACSKPD DNPTSL
//
