ID B3SUE1_SALSA Unreviewed; 357 AA.
AC B3SUE1;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Homeobox protein Hox-A2b {ECO:0000313|RefSeq:NP_001124328.1};
DE SubName: Full=Homeobox protein HoxA2b {ECO:0000313|EMBL:ABV82058.1};
GN Name=HoxA2b {ECO:0000313|EMBL:ABV82058.1};
GN Synonyms=hoxa2b {ECO:0000313|RefSeq:NP_001124328.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ABV82058.1};
RN [1] {ECO:0000313|EMBL:ABV82058.1, ECO:0000313|RefSeq:NP_001124328.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18424774; DOI=10.1093/molbev/msn097;
RA Mungpakdee S., Seo H.C., Angotzi A.R., Dong X., Akalin A., Chourrout D.;
RT "Differential evolution of the 13 Atlantic salmon Hox clusters.";
RL Mol. Biol. Evol. 25:1333-1343(2008).
RN [2] {ECO:0000313|RefSeq:NP_001124328.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC subfamily. {ECO:0000256|ARBA:ARBA00038135}.
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DR EMBL; EF695323; ABV82058.1; -; mRNA.
DR EMBL; EU025703; ABW77460.1; -; Genomic_DNA.
DR RefSeq; NP_001124328.1; NM_001130856.1.
DR STRING; 8030.ENSSSAP00000004208; -.
DR PaxDb; 8030-ENSSSAP00000004208; -.
DR GeneID; 100170849; -.
DR KEGG; sasa:100170849; -.
DR CTD; 30325; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000087266; Chromosome ssa05.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF3; HOMEOBOX PROTEIN HOX-A2; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 131..191
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 133..192
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 59..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 39278 MW; 112B34918A80A115 CRC64;
MNYDFERESG FINSQPSLAE CLTSFTPVGD AFQSSSIKNS TLSQSTLIPP PFEQTIPSLN
PCSHPRHSRS KQNLNGVCSP QPAAALPPEY PWMKEKKASK KNHQTTATSP DTAPLHFSPQ
GSPETAESGG GGSRRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL NLTERQVKVW
FQNRRMKHKR QTHCKENQDG EGTFTSLEDG REEDFDQAGN NVGLPAGALL ERESCSFQQN
TLTSQQQSQN AHNDNGDSQS STASHLKSDD KNLKNFPNTA PTVPICVSTI GPDYASGGDN
AHSPALGVSL QDFHVFSSDS FSPSLSDSID SPMGLSSEGF DFFSETLTTI DLQHLSY
//
