ID B3TD83_SALSA Unreviewed; 377 AA.
AC B3TD83;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Homeobox protein HoxA2aa {ECO:0000313|EMBL:ABW77445.1};
GN Name=HoxA2aa {ECO:0000313|EMBL:ABW77445.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ABW77445.1};
RN [1] {ECO:0000313|EMBL:ABW77445.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18424774; DOI=10.1093/molbev/msn097;
RA Mungpakdee S., Seo H.C., Angotzi A.R., Dong X., Akalin A., Chourrout D.;
RT "Differential evolution of the 13 Atlantic salmon Hox clusters.";
RL Mol. Biol. Evol. 25:1333-1343(2008).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC subfamily. {ECO:0000256|ARBA:ARBA00038135}.
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DR EMBL; EU025688; ABW77445.1; -; Genomic_DNA.
DR AlphaFoldDB; B3TD83; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF3; HOMEOBOX PROTEIN HOX-A2; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 135..195
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 137..196
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 59..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 41114 MW; 1DD822092B226C87 CRC64;
MNYEFERESG FINSQPSLAE CLTSFPPVGD SFQSSSIKRS TLSRSTLIPP PFEQTILSLN
PGSHPRHSRP RLSPDGCIPL PTASLPPEYP WMREKKATKK NHLPTSTATA IASGPVCFSP
EDSPEILEGG GGGGGSSRRL RTAYTNTQLL ELEKEFHFNK YLCRPRRVEI AALLDLTERQ
VKVWFQNRRM KHKRQTQCKE NHNGEGKGPS AGDGIQSNDE EDDGSLFEQS LNTVTGALME
REACSFQHNS LSSSQQLQNV GPHNGEAQSY TVSPLSSNDK NLKHFLNPSP TVPGCVSTIG
SGSATGPDNG GSPPALDVSI HDFQVFPSDS CLHLSDAASP SLSESLDSPV DNLDISTDSF
YFFSESLTTI DLQHLSY
//
