ID B3VLE2_GIAIN Unreviewed; 231 AA.
AC B3VLE2;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=glutamate dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00012907};
DE EC=1.4.1.4 {ECO:0000256|ARBA:ARBA00012907};
DE Flags: Fragment;
GN Name=gdh {ECO:0000313|EMBL:AEJ86589.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ACF05216.2};
RN [1] {ECO:0000313|EMBL:ACF05216.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Swecat171 {ECO:0000313|EMBL:ACF05216.2};
RA Lebbad M., Mattsson J.G., Christensson B., Ljungstrom B., Backhans A.,
RA Andersson J.O., Svard S.G.;
RT "From mouse to moose: Multilocus genotyping of Giardia isolates from
RT various animal species.";
RL Vet. Parasitol. 168:231-239(2010).
RN [2] {ECO:0000313|EMBL:AEJ86589.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Swecat035 {ECO:0000313|EMBL:AEJ86591.1}, Swecat078
RC {ECO:0000313|EMBL:AEJ86592.1}, Swefd165 {ECO:0000313|EMBL:AEJ86593.1},
RC Swesheep015 {ECO:0000313|EMBL:AEJ86589.1}, and Swesheep016
RC {ECO:0000313|EMBL:AEJ86590.1};
RX PubMed=19969422; DOI=10.1016/j.vetpar.2009.11.003;
RA Lebbad M., Mattsson J.G., Christensson B., Ljungstrom B., Backhans A.,
RA Andersson J.O., Svard S.G.;
RT "From mouse to moose: multilocus genotyping of Giardia isolates from
RT various animal species.";
RL Vet. Parasitol. 168:231-239(2010).
RN [3] {ECO:0000313|EMBL:ACT78390.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sweh166 {ECO:0000313|EMBL:ACT78390.2}, Sweh173
RC {ECO:0000313|EMBL:ACT78391.2}, and Sweh178
RC {ECO:0000313|EMBL:ACT78392.2};
RX PubMed=21829745; DOI=10.1371/journal.pntd.0001262;
RA Lebbad M., Petersson I., Karlsson L., Botero-Kleiven S., Andersson J.O.,
RA Svenungsson B., Svard S.G.;
RT "Multilocus Genotyping of Human Giardia Isolates Suggests Limited Zoonotic
RT Transmission and Association between Assemblage B and Flatulence in
RT Children.";
RL PLoS Negl. Trop. Dis. 5:E1262-E1262(2011).
RN [4] {ECO:0000313|EMBL:ACT78390.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sweh166 {ECO:0000313|EMBL:ACT78390.2}, Sweh173
RC {ECO:0000313|EMBL:ACT78391.2}, and Sweh178
RC {ECO:0000313|EMBL:ACT78392.2};
RA Lebbad M., Peterson I., Svenungsson B., Svard S.;
RT "Molecular characterization of Giardia isolates from Swedish patients.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AEJ86589.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Swecat035 {ECO:0000313|EMBL:AEJ86591.1}, Swecat078
RC {ECO:0000313|EMBL:AEJ86592.1}, Swefd165 {ECO:0000313|EMBL:AEJ86593.1},
RC Swesheep015 {ECO:0000313|EMBL:AEJ86589.1}, and Swesheep016
RC {ECO:0000313|EMBL:AEJ86590.1};
RA Lebbad M., Mattsson J.G., Christensson B., Ljungstrom B., Backhans A.O.,
RA Andersson J.O., Svard S.G.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:ACF05216.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Swecat171 {ECO:0000313|EMBL:ACF05216.2};
RA Lebbad M., Mattsson J., Christensson B., Ljungstrom B., Andersson J.O.,
RA Svard S.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
CC {ECO:0000256|ARBA:ARBA00006382, ECO:0000256|RuleBase:RU004417}.
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DR EMBL; EU769223; ACF05216.2; -; Genomic_DNA.
DR EMBL; GQ329674; ACT78390.2; -; Genomic_DNA.
DR EMBL; GQ329675; ACT78391.2; -; Genomic_DNA.
DR EMBL; GQ329676; ACT78392.2; -; Genomic_DNA.
DR EMBL; JF773750; AEJ86589.1; -; Genomic_DNA.
DR EMBL; JF773751; AEJ86590.1; -; Genomic_DNA.
DR EMBL; JF773752; AEJ86591.1; -; Genomic_DNA.
DR EMBL; JF773753; AEJ86592.1; -; Genomic_DNA.
DR EMBL; JF773754; AEJ86593.1; -; Genomic_DNA.
DR AlphaFoldDB; B3VLE2; -.
DR GO; GO:0004353; F:glutamate dehydrogenase [NAD(P)+] activity; IEA:UniProt.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR006095; Glu/Leu/Phe/Val/Trp_DH.
DR InterPro; IPR006096; Glu/Leu/Phe/Val/Trp_DH_C.
DR InterPro; IPR006097; Glu/Leu/Phe/Val/Trp_DH_dimer.
DR InterPro; IPR033524; Glu/Leu/Phe/Val_DH_AS.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43571; NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED; 1.
DR PANTHER; PTHR43571:SF1; NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED; 1.
DR Pfam; PF00208; ELFV_dehydrog; 1.
DR Pfam; PF02812; ELFV_dehydrog_N; 1.
DR PRINTS; PR00082; GLFDHDRGNASE.
DR SMART; SM00839; ELFV_dehydrog; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00074; GLFV_DEHYDROGENASE; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004417}.
FT DOMAIN 115..228
FT /note="Glutamate/phenylalanine/leucine/valine/L-tryptophan
FT dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00839"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF05216.2"
FT NON_TER 231
FT /evidence="ECO:0000313|EMBL:ACF05216.2"
SQ SEQUENCE 231 AA; 25626 MW; 17B894A36EEC3EF7 CRC64;
PYKGGLRFHP SVNLSILKFL GFEQILKNSL TTLPMGGGKG GSDFDPKGKS DNEVMRFCQS
FMTELQRHVG ADTDVPAGDI GVGAREIGYL YGQYKRLRNE FTGVLTGKNV KWGGSFIRPE
ATGYGAVYFL EEMCKDNNTV IRGKNVLLSG SGNVAQFACE KLIQLGAKVL TFSDSNGTIV
DKDGFNEEKL AHLMYLKNEK RGRVSEFKDK YPSVAYYEGK KPWECFEGQV D
//
