ID B3XVX8_9EUKA Unreviewed; 792 AA.
AC B3XVX8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN Name=CgPTK-c {ECO:0000313|EMBL:BAG55513.1};
OS Hartaetosiga gracilis.
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Hartaetosiga.
OX NCBI_TaxID=216892 {ECO:0000313|EMBL:BAG55513.1};
RN [1] {ECO:0000313|EMBL:BAG55513.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18267119; DOI=10.1016/j.febslet.2008.02.002;
RA Suga H., Sasaki G., Kuma K., Nishiyori H., Hirose N., Su Z.H., Iwabe N.,
RA Miyata T.;
RT "Ancient divergence of animal protein tyrosine kinase genes demonstrated by
RT a gene family tree including choanoflagellate genes.";
RL FEBS Lett. 582:815-818(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149};
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DR EMBL; AB098191; BAG55513.1; -; mRNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24418:SF468; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAG55513.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 434..527
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 540..792
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 86..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..317
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 569
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 792 AA; 88149 MW; 3D6E041D6F54934A CRC64;
MFNIVDVLDR INKDLAFSGI SDLNAFVISE DTHRQIRTFQ SDAKFTTSDL NGNLSVFLQK
ETTADYGTLN ERPILNTPDV RSMTYFGQTE ENNNDGSDGS NEDNGVREVL MDSGTGTVGD
RRNTFEDLVM EQRSATLKEH QAKYKAFLEQ YLKKLFREQQ SKMADTLEAL LLGLSNIPKT
EDLMLQTTIR SRTASDALLM KQVVNKNSSN AQTLPDVGDG SATLKKKGMF NGMLFTKKTS
KTDVLTPRPK LSRPDLGDEY EEVDDNDASS EISKQEGDGD QQQQHQEDDA DADDTDDADD
ADDADDADDA DDADDADGDC KDNVKGQNES EVNLGDVESP LMLPIDGVNT SETATDSKTV
LSKENILDTQ QHTTQDAVTF CHVASSETST TPPPSLPTAE RMPMGQPVVN KQTSMQLTAG
DGRDGGQSVE DLECYFGPIP RNEVPMILSD PGDFLIRLGS ENSATKYVLS VLEEGGNCRH
FNIFYCPNGY VKIEKQEFPS ISHLIRHYID NDLSLSKNSG VTIAHGVSRK KMEIWKPKDL
ESAAKLGKGC FGVVQKMKSK ISDDVFAVKT CSDESVHPWE FLKEALDFAK FKHVNICVHR
GISLSFPYFI LMDLCGNGAV NSYLHDHKDT SLEIKFKWAL EACEGMEYLT TNNVVHRDLA
ARNCLLTDDL VLKISDFGLS RLVTDEDQIY LSRKAKIPYK WTAPEALNGE GFTAKSDVWS
YGVLLWEIYN VNALPFRAIP NNELYDXLKA GSXLPRGDAT QDIYDLVLMP CWTFNRDERP
SFTDVKALLN SF
//
