ID B3XXC1_PIG Unreviewed; 1050 AA.
AC B3XXC1;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:BAG68214.1};
GN Name=TLR7 {ECO:0000313|EMBL:BAG68214.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:BAG68214.1};
RN [1] {ECO:0000313|EMBL:BAG68214.1}
RP NUCLEOTIDE SEQUENCE.
RA Morozumi T., Uenishi H., Awata T.;
RT "Molecular cloning and characterization of porcine TLR7 and TLR8.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-
CC like receptors) control host immune response against pathogens through
CC recognition of molecular patterns specific to microorganisms. TLR9 is a
CC nucleotide-sensing TLR which is activated by unmethylated cytidine-
CC phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. Upon CpG stimulation, induces B-cell
CC proliferation, activation, survival and antibody production.
CC {ECO:0000256|ARBA:ARBA00024895}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; AB291813; BAG68214.1; -; Genomic_DNA.
DR AlphaFoldDB; B3XXC1; -.
DR SMR; B3XXC1; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00365; LRR_SD22; 11.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:BAG68214.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 841..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 890..1034
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1050 AA; 120924 MW; 64DA0024C2D354A3 CRC64;
MVFPVWTLKR QFLILFNIVL ISELLGARWF PKTLPCDVSL DAPNAHVIVD CTDKHLTAIP
GGIPTNATNL TLTINHIASI TPASFQQLDH LVEIDFRCNC IPVRLGPKDN LCTRRLQIKP
SSFSKLTYLK ALYLDGNQLL EIPRDLPPSL QLLSLEANNI FWIMKENLTE LANLEMLYLG
QNCYYRNPCN VSFSIEKDAF LSLRNLKLLS LKDNNISAVP TVLPSTLTEL FLYNNIIAKI
QEDDFNNLSQ LQVLDLSGNC PRCYNVPFPC TPCENNAPLQ IHLHAFDALT ELQVLRLHSN
SLQYVPQRWF QNLNKLKELD LSQNFLAKEI GDAKFLHLLH NLVKLDLSFN YELQVYHTFM
NLSDSFSSLK NLKVLRIKGY VFKELKSLNL SPLRNLPNLE VLDLGTNFIK IANLSIFKQF
KTLKFIDLSV NKISPSGDSS ESGFCSGMRT SAESHGPQVL ESLHYFRYDE YARSCRFKNK
EPSSSLPLNE DCSMYGQTLD LSRNNIFFIR SSEFQHLTFL KCLNLSGNSI SQALNGSEFQ
PLVELKYLDF SNNRLDLLHS TAFEELRNLE VLDISSNSHY FQSEGITHML DFTKNLKVLK
KLMMNNNDIA TSTSTTMESE SLRILEFRGN HLDILWRDGD NRYLKFFKNL HKLEELDISE
NSLSFLPSGV FDGMPPNLKT LSLAKNGLKS FNWGKLQYLQ NLETLDLSYN QLKTVPERLS
NCSRSLKKLI LKNNEIRNLT KYFLQDAFQL RHLDLSSNKI QVIQKTSFPE NVLNNLQILF
LHHNRFLCNC DAVWLVWWVN HTEVTIPFLA TDVTCMGPGA HKGQSVVSLD LYTCELDLTN
FVLFSLSLSA VLFLIVITIA NHLYFWDVWY SYHFCKAKIK GYQRLISPNS CYDAFIVYDT
KDPAVTEWVL DELVAKLEDP REKHFNLCLE ERDWLPGQPV LENLSQSIQL SKKTVFVMTD
KYAKTEKFKI AFYLSHQRLM DEKVDVIILI FLEKPLQKSK FFQLRKRLCG SSVLEWPTNP
QAHPYFWQCL KNALATDNHV TYSQVFKETA
//
