ID B3XXJ8_GRYBI Unreviewed; 1184 AA.
AC B3XXJ8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE Flags: Fragment;
GN Name=egfr {ECO:0000313|EMBL:BAG65666.1};
OS Gryllus bimaculatus (Two-spotted cricket).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Orthoptera; Ensifera; Gryllidea; Grylloidea;
OC Gryllidae; Gryllinae; Gryllus.
OX NCBI_TaxID=6999 {ECO:0000313|EMBL:BAG65666.1};
RN [1] {ECO:0000313|EMBL:BAG65666.1}
RP NUCLEOTIDE SEQUENCE.
RA Nakamura T., Mito T., Miyawaki K., Ohuchi H., Noji S.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAG65666.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18486122; DOI=10.1016/j.ydbio.2008.04.002;
RA Nakmura T., Mito T., Miyawaki K., Ohuchi H., Noji S.;
RT "EGFR signaling is required for re-establishing the proximodistal axis
RT during distal leg regeneration in the cricket Gryllus bimaculatus nymph.";
RL Dev. Biol. 319:46-55(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AB300616; BAG65666.1; -; mRNA.
DR AlphaFoldDB; B3XXJ8; -.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00064; FU; 4.
DR CDD; cd05057; PTKc_EGFR_like; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF566; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 7.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000619-
KW 2}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|EMBL:BAG65666.1}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1184
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002799141"
FT TRANSMEM 801..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 872..1129
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 997
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 878..886
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 905
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1184
FT /evidence="ECO:0000313|EMBL:BAG65666.1"
SQ SEQUENCE 1184 AA; 131836 MW; 6D97FEBC2BCB12E7 CRC64;
MGAPGLLLLL LVLLAALGDC GPRGASAVIE ERVCIGTNGR ISVPSNREHH YRNLRERYTN
CTYVDGNLEV TWLEDPQLDL SFLQHIREVT GYVLISHVNV PRVVLPALQI IRGRTLFRIA
VHDEDFALMI LLSKMNSLEM PALRDILQGN VGLLNNYNLC HIRTINWDDI ITGPGAHVVH
VYNFTMPERE CPPCHSSCEN GCWGEGPHNC QKFSKINCSP QCHQGRCFGT NPRECCHLFC
AGGCRGPKQS DCLACRNFYD NGVCTQECPP MQRYNSITYS WESNPDGKYA YGATCVKKCP
DHLLKDNGAC VRSCPQNKRA VEGECVQCDG PCPKKCEGES SVHSGNIEKF KNCTIIEGSI
SILDTSFKGF QQIYSNYTFG ERYEPMHPDR LEVFSTLKEI TGYLHIDGSH QDFRNLSYFR
NLETIGGRQL TDYFASLYIV KTTLTSFGLK SLKKISSGSI AILENRDLCF AESLNWTRIK
ASADHSVLQG NNRKTEECIA AGMVCDKECS DEGCWGPGAD QCLSCAHFHL GSRCIHNCNS
LPGIYQSGEK MCSYCHEECA STCNGPGPGN CTSCKHTKDG PFCTAECPVT KYASENGECK
PCHSNCVDGC TGPYNTVGSG GCNSCEKAII NGNVTVGMCL QKNESCPDGY YNEYMGPQEQ
GSLKPLEGKA ICRSCHPRCK KCTGYGFHEQ VCQECALYKR GEQCEDECPF DHYAVESHHE
CMPCDQECRE CYGPTNSECK ACRNMRLWTD TNHNSSSFNC TGTCPPEMPY KIFPIVPSDG
EPYCKRSAGR CRRTAGHNSS YPTMFGIGVF VCLSIIAGLA MIFWVYRRKA KAKENAVKMT
MVMTGLEDNE PLRPTNVKPN LAKLRIVKEA ELRKGSVLGY GAFGTVYKGV WVPEGENIKI
PVAIKALREG TSSNTSKEFL EEAYIMASVE HPNLLQLLAV CLASQMMLVT QLMPLGCLLD
YVRNNRGRVG SKPLVNWCTQ IARGMAYLEE KRLVHRDLAA RNVLVQTPPC VKITDFGLAK
LLAINEDEYK AAGGKMPIKW LALECIQHRI FTHKSDVWAF GVTVWELLTY GGRPYESVPA
RDVPELLEKG ERLPQPTICT IDVYLLMIKC WMLDAESRPS FKELADEFAA MARDPGRFLV
IQGDRFMKLP SYSGQDEKEM IRNLSSPVEG PEALVDADEY LQPK
//
