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Database: UniProt
Entry: B4DDM5_HUMAN
LinkDB: B4DDM5_HUMAN
Original site: B4DDM5_HUMAN 
ID   B4DDM5_HUMAN            Unreviewed;       717 AA.
AC   B4DDM5;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   13-SEP-2023, entry version 66.
DE   SubName: Full=cDNA FLJ53298, highly similar to Peroxisomal multifunctional enzyme type 2 {ECO:0000313|EMBL:BAG56786.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG56786.1};
RN   [1] {ECO:0000313|EMBL:BAG56786.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
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DR   EMBL; AK293254; BAG56786.1; -; mRNA.
DR   AlphaFoldDB; B4DDM5; -.
DR   PeptideAtlas; B4DDM5; -.
DR   UniPathway; UPA00659; -.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd03448; HDE_HSD; 1.
DR   CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 1.
DR   Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR   Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR002539; MaoC-like_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR13078:SF56; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2; 1.
DR   PANTHER; PTHR13078; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF01575; MaoC_dehydratas; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF55718; SCP-like; 1.
DR   SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT   DOMAIN          465..581
FT                   /note="MaoC-like"
FT                   /evidence="ECO:0000259|Pfam:PF01575"
FT   DOMAIN          609..712
FT                   /note="SCP2"
FT                   /evidence="ECO:0000259|Pfam:PF02036"
SQ   SEQUENCE   717 AA;  77428 MW;  453D578F1B81CBA9 CRC64;
     MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE
     EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWEHMK
     KQKYGRIIMT SSASGIYGNF GQANYSAAKL GLLGLANSLA IEGRKSNIHC NTIAPNAGSR
     MTQTVMPEDL VEALKPEYVA PLVLWLCHES CEENGGLFEV GAGWIGKLRW ERTLGAIVRQ
     KNHPMTPEAV KANWKKICDF ENASKPQSIQ ESSGSIIEVL SKIDSEGGVS ANHTSRATST
     ATSGFAGAIG QKLPPFSYAY TELEAIMYAL GVGASIKDPK DLKFIYEGSS DFSCLPTFGV
     IIGQKSMMGG GLAEIPGLSI NFAKVLHGEQ YLELYKPLPR AGKLKCEAVV ADVLDKGSGV
     VIIMDVYSYS EKELICHNQF SLFLVGSGGF GGKRTSDKVK VAVAIPNRPP DAVLTDTTSL
     NQAALYRLSG DWNPLHIDPN FASLAGFDKP ILHGLCTFGF SARRVLQQFA DNDVSRFKAI
     KARFAKPVYP GQTLQTEMWK EGNRIHFQTK VQETGDIVIS NAYVDLAPTS GTSAKTPSEG
     GKLQSTFVFE EIGRRLKDIG PEVVKKVNAV FEWHITKGGN IGAKWTIDLK SGSGKVYQGP
     AKGAADTTII LSDEDFMEVV LGKLDPQKAF FSGRLKARGN IMLSQKLQMI LKDYAKL
//
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