ID B4DGQ8_HUMAN Unreviewed; 243 AA.
AC B4DGQ8; C9JFT5;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=cDNA FLJ50145, highly similar to Homo sapiens Cdc42 guanine nucleotide exchange factor (GEF) 9 (ARHGEF9), mRNA {ECO:0000313|EMBL:BAG57869.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG57869.1};
RN [1] {ECO:0000313|EMBL:BAG57869.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAG57869.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK294721; BAG57869.1; -; mRNA.
DR AlphaFoldDB; B4DGQ8; -.
DR SMR; B4DGQ8; -.
DR MaxQB; B4DGQ8; -.
DR PeptideAtlas; B4DGQ8; -.
DR ProteomicsDB; 4152; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 1..58
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 90..152
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 180..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 243 AA; 28711 MW; E10074D37810F0AE CRC64;
MIDIAIDGFL LTPVQKICKY PLQLAELLKY TAQDHSDYRY VAAALAVMRN VTQQINERKR
RLENIDKIAQ WQASVLDWED LIRRDILYYK GRIDMDKYEV VDIEDGRDDD FNVSMKNAFK
LHNKETEEIH LFFAKKLEEK IRWLRAFREE RKMVQEDEKI GFEISENQKR QAAMTVRKVP
KQKGVNSARS VPPSYPPPQD PLNHGQYLVP DGIAQSQVFE FTEPKRSQSP FWQNFSRLTP
FKK
//
