ID   B4DGU8_HUMAN            Unreviewed;       806 AA.
AC   B4DGU8;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=cDNA FLJ60110, highly similar to Homo sapiens leucine-rich repeats and IQ motif containing 2 (LRRIQ2), mRNA {ECO:0000313|EMBL:BAG57909.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG57909.1};
RN   [1] {ECO:0000313|EMBL:BAG57909.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAG57909.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK294784; BAG57909.1; -; mRNA.
DR   RefSeq; NP_001290330.1; NM_001303401.1.
DR   AlphaFoldDB; B4DGU8; -.
DR   PeptideAtlas; B4DGU8; -.
DR   DNASU; 79598; -.
DR   GeneID; 79598; -.
DR   CTD; 79598; -.
DR   OrthoDB; 2881819at2759; -.
DR   BioGRID-ORCS; 79598; 160 hits in 1175 CRISPR screens.
DR   GenomeRNAi; 79598; -.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR45973:SF9; CENTROSOMAL PROTEIN 97KDA, ISOFORM B-RELATED; 1.
DR   PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR   Pfam; PF14580; LRR_9; 1.
DR   SMART; SM00365; LRR_SD22; 3.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   REGION          447..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          656..710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          531..558
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        656..678
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        684..703
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   806 AA;  90268 MW;  4C3C50ACE8519EBD CRC64;
     MAVARVDAAL PPGEGSVVNW SGQGLQKLGP NLPCEADIHT LILDKNQIIK LENLEKCKQL
     IQLSVANNRL VRMMGVAKLT LLRVLNLPHN SIGCVEGLKE LVHLEWLNLA GNNLKAMEQI
     NSCTALQHLD LSDNNISQIG DLSKLVSLKT LLLHGNIITS LRMAPAYLPR SLAILSLAEN
     EIRDLNEISF LASLTELEQL SIMNNPCVMA TPSIPGFDYR PYIVSWCLNL RVLDGYVISQ
     KESLKAEWLY SQGKGRAYRP GQHIQLVQYL ATVCPLTSTL GLQTAEDAKL EKILSKQRFH
     QRQLMNQSQN EELSPLVPVE TRASLIPEHS SPVQDCQISQ ESESTFMPVA SGLSPLSPTV
     ELRLQGINLG LEDDGVADES VKGLESQVLD KEEEQPLWAA NENSVQMMRS EINTEVNEKA
     GLLPCPEPTI ISAILKDDNH SLTFFPESTE QKQSDIKKPE NTQPENKETI SQATSDKLPM
     ILTQRSVALG QDKVALQKLN DAATKLQACW RGFYARNYNP QAKDVRYEIR LRRMQEHIVC
     LTDEIRRLRK ERDEERIKKF VQEEAFRFLW NQVRSLQVWQ QTVDQRLSSW HTDVPPISST
     LVPSKHPLFT QSQESSCDQN ADWFIASDVA PQEKSLPEFP DSGFHSSLTE QVHSLQHSLD
     FEKSSTEGSE SSIMGNSIDT VRYGKESDLG DVSEEHGEWN KESSNNEQDN SLLEQYLTSV
     QQLEDADERT NFDTETRDSK LHIACFPVQL DTLSDGASVD ESHGISPPLQ GEISQTQENS
     KLNAEVQGQQ PECDSTFQLL HVGVTV
//