ID B4DLR3_HUMAN Unreviewed; 784 AA.
AC B4DLR3;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=cDNA FLJ54020, highly similar to Heterogeneous nuclear ribonucleoprotein U {ECO:0000313|EMBL:BAG59625.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG59625.1};
RN [1] {ECO:0000313|EMBL:BAG59625.1}
RP NUCLEOTIDE SEQUENCE.
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AK297119; BAG59625.1; -; mRNA.
DR AlphaFoldDB; B4DLR3; -.
DR SMR; B4DLR3; -.
DR MaxQB; B4DLR3; -.
DR PeptideAtlas; B4DLR3; -.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR CDD; cd12884; SPRY_hnRNP; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035778; SPRY_hnRNP_U.
DR PANTHER; PTHR12381:SF11; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U; 1.
DR PANTHER; PTHR12381; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF02037; SAP; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00513; SAP; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50800; SAP; 1.
PE 2: Evidence at transcript level;
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Ribonucleoprotein {ECO:0000313|EMBL:BAG59625.1}.
FT DOMAIN 8..42
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 227..423
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 41..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..132
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 86861 MW; 3A784474A2AA786F CRC64;
MSSSPVNVKK LKVSELKEEL KKRRLSDKGL KAELMERLQA ALDDEEAGGR PAMEPGNGSL
DLGGDSAGRS GAGLEQEAAA GGDEEEEEEE EEEEGISALD GDQMELGEEN GDDQGFQEGE
DELGDEEEGA GDENGHGEQQ PQPPATQQQQ PQQQRGAAKE AAGKSSGPTS LFAVTVAPPG
ARQGQQQAGG DGKTEQKGGD KKRGVKRPRE DHGRGYFEYI EENKYSRAKS PQPPVEEEDE
HFDDTVVCLD TYNCDLHFKI SRDRLSASSL TMESFAFLWA GGRASYGVSK GKVCFEMKVT
EKIPVRHLYT KDIDIHEVRI GWSLTTSGML LGEEEFSYGY SLKGIKTCNC ETEDYGEKFD
ENDVITCFAN FESDEVELSY AKNGQDLGVA FKISKEVLAG RPLFPHVLCH NCAVEFNFGQ
KEKPYFPIPE EYTFIQNVPL EDRVRGPKGP EEKKDCEVVM MIGLPGAGKT TWVTKHAAEN
PGKYNILGTN TIMDKMMVAG FKKQMADTGK LNTLLQRAPQ CLGKFIEIAA RKKRNFILDQ
TNVSAAAQRR KMCLFAGFQR KAVVVCPKDE DYKQRTQKKA EVEGKDLPEH AVLKMKGNFT
LPEVAECFDE ITYVELQKEE AQKLLEQYKE ESKKALPPEK KQNTGSKKSN KNKSGKNQFN
RGGGHRGRGG FNMRGGNFRG GAPGNRGGYN RRGNMPQRGG GGGGSGGIGY PYPRAPVFPG
RGSYSNRGNY NRGGMPNRGN YNQNFRGRGN NRGYKNQSQG YNQWQQGQFW GQKPWSQHYH
QGYY
//
