ID B4DMS9_HUMAN Unreviewed; 657 AA.
AC B4DMS9;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 22-FEB-2023, entry version 63.
DE SubName: Full=cDNA FLJ59577, highly similar to Bromodomain-containing protein 8 {ECO:0000313|EMBL:BAG59991.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG59991.1};
RN [1] {ECO:0000313|EMBL:BAG59991.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAG59991.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK297608; BAG59991.1; -; mRNA.
DR RefSeq; NP_001287891.1; NM_001300962.1.
DR AlphaFoldDB; B4DMS9; -.
DR PeptideAtlas; B4DMS9; -.
DR DNASU; 10902; -.
DR GeneID; 10902; -.
DR CTD; 10902; -.
DR OrthoDB; 2919186at2759; -.
DR BioGRID-ORCS; 10902; 291 hits in 1183 CRISPR screens.
DR GenomeRNAi; 10902; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05507; Bromo_brd8_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR037966; Brd8_Bromo_dom.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR PANTHER; PTHR15398; BROMODOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR15398:SF4; BROMODOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 503..573
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 335..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 71502 MW; DB4651ED0B6D6CB4 CRC64;
MQELLSSFET IRIFLVESSS SYCFLFMCFL LTSFCVPLYM LGAPTLSRLL EAGPTQFTTP
LASFTTVASE PPVKLVPPPV ESVSQATIVM MPALPAPSSA PAVSTTESVA PVSQPDNCVP
MEAVGDPHTV TVSMDSSEIS MIINSIKEEC FRSGVAEAPV GSKAPSIDGK EELDLAEKMD
IAVSYTGEEL DFETVGDIIA IIEDKVDDHP EVLDVAAVEA ALSFCEENDD PQSLPGPWEH
PIQQERDKPV PLPAPEMTVK QERLDFEEME NKGIHELVDI REPSAEIKVE PAEPEPVISG
AEIVAGVVPA TSMEPPELRS QDLDEELGST AAGEIVEADV AIGKGDETPL TNVKTEASPE
SMLSPSHGSN PIEDPLEAET QHKFEMSDSL KEESGTIFGS QIKDAPGEDE EEDGVSEAAS
LEEPKEEDQG EGYLSEMDNE PPVSESDDGF SIHNATLQSH TLADSIPSSP ASSQFSVCSE
DQEAIQAQKI WKKAIMLVWR AAANHRYANV FLQPVTDDIA PGYHSIVQRP MDLSTIKKNI
ENGLIRSTAE FQRDIMLMFQ NAVMYNSSDH DVYHMAVEMQ RDVLEQIQQF LATQLIMQTS
ESGISAKSLR GRDSTRKQDA SEKDSVPMGS PAFLLSLFDG GTRGRRCAIE ADMKMKK
//
