ID B4DYT8_HUMAN Unreviewed; 323 AA.
AC B4DYT8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Zinc transporter ZIP3 {ECO:0000256|ARBA:ARBA00039395};
DE AltName: Full=Solute carrier family 39 member 3 {ECO:0000256|ARBA:ARBA00042778};
DE AltName: Full=Zrt- and Irt-like protein 3 {ECO:0000256|ARBA:ARBA00041702};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG63850.1};
RN [1] {ECO:0000313|EMBL:BAG63850.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:BAG63850.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00036307};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29352;
CC Evidence={ECO:0000256|ARBA:ARBA00036307};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; AK302600; BAG63850.1; -; mRNA.
DR AlphaFoldDB; B4DYT8; -.
DR PeptideAtlas; B4DYT8; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR11040:SF214; ZINC TRANSPORTER ZIP3; 1.
DR PANTHER; PTHR11040; ZINC/IRON TRANSPORTER; 1.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 323 AA; 34492 MW; 248AFC53D99E2DA9 CRC64;
MVKLLVAKIL CMVGVFFFML LGSLLPVKII ETDFEKAHRS KKILSLCNTF GGGVFLATCF
NALLPAVREK LQKVLSLGHI STDYPLAETI LLLGFFMTVF LEQLILTFRK EKPSFIDLET
FNAGSDVGSD SEYESPFMGG ARGHALYVEP HGHGPSLSVQ GLSRASPVRL LSLAFALSAH
SVFEGLALGL QEEGEKVVSL FVGVAVHETL VAVALGISMA RSAMPLRDAA KLAVTVSAMI
PLGIGLGLGI ESAQGVPGSV ASVLLQGLAG GTFLFITFLE ILAKELEGKS DRLLKVLFLV
LGYTVLAGMV FLKWISPPEP RVS
//
