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Database: UniProt
Entry: B4E0A0_HUMAN
LinkDB: B4E0A0_HUMAN
Original site: B4E0A0_HUMAN 
ID   B4E0A0_HUMAN            Unreviewed;       498 AA.
AC   B4E0A0;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   08-NOV-2023, entry version 59.
DE   RecName: Full=Cytochrome P450 {ECO:0000256|RuleBase:RU368047};
DE            EC=1.14.14.- {ECO:0000256|RuleBase:RU368047};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG64362.1};
RN   [1] {ECO:0000313|EMBL:BAG64362.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thymus {ECO:0000313|EMBL:BAG64362.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       In liver microsomes, this enzyme is involved in an NADPH-dependent
CC       electron transport pathway. It oxidizes a variety of structurally
CC       unrelated compounds, including steroids, fatty acids, and xenobiotics.
CC       {ECO:0000256|RuleBase:RU368047}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|ARBA:ARBA00001971,
CC         ECO:0000256|RuleBase:RU368047};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU368047}. Microsome membrane
CC       {ECO:0000256|RuleBase:RU368047}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR   EMBL; AK303284; BAG64362.1; -; mRNA.
DR   AlphaFoldDB; B4E0A0; -.
DR   PeptideAtlas; B4E0A0; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   CDD; cd20666; CYP2U1; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24300:SF364; CYTOCHROME P450 2U1; 1.
DR   PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01686; EP450ICYP2D.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000461};
KW   Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461}.
SQ   SEQUENCE   498 AA;  57049 MW;  A195CC7F608D7D1E CRC64;
     MSSPGPSQPP AEDPPWPTPW PLVGNFGHVL LPPFLRRRSW LSSRTRAAGI DPSVIGPQVL
     LAHLARVYGS IFSFFIGHYL VVVLSDFHSV REALVQQAEV FSDRPRVPLI SIVTKEKGVV
     FAHYGPVWRQ QRKFSHSTLR HFGLGKLSLE PKIIEEFKYV KAEMQKHGED PFCPFSIISN
     AVSNIICSLC FGQRFDYTNS EFKKMLGFMS RGLEICLNSQ VLLVNICPWL YYLPFGPFKE
     LRQIEKDITS FLKKIIKDHQ ESLDRENPQD FIDMYLLHME EERKNNSNSS FDEEYLFYII
     GDLFIAGTDT TTNSLLWCLL YMSLNPDVQE KVHEEIERVI GANRAPSLTD KAQMPYTEAT
     IMEVQRLTVV VPLAIPHMTS ENTVLQGYTI PKGTLILPNL WSVHRDPAIW EKPEDFYPNR
     FLDDQGQLIK KETFIPFGIG KRVCMGEQLA KMELFLMFVS LMQSFAFALP EDSKKPLLTG
     RFGLTLAPHP FNITISRR
//
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