ID   B4E3M6_HUMAN            Unreviewed;       941 AA.
AC   B4E3M6;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=cDNA FLJ55446, highly similar to Superkiller viralicidic activity 2-like 2 {ECO:0000313|EMBL:BAG65538.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG65538.1};
RN   [1] {ECO:0000313|EMBL:BAG65538.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Uterus {ECO:0000313|EMBL:BAG65538.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK304788; BAG65538.1; -; mRNA.
DR   AlphaFoldDB; B4E3M6; -.
DR   PeptideAtlas; B4E3M6; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18024; DEXHc_Mtr4-like; 1.
DR   CDD; cd13154; KOW_Mtr4; 1.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 2.
DR   Gene3D; 2.40.30.300; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR048392; MTR4-like_stalk.
DR   InterPro; IPR025696; MTR4_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21408; MTR4-like_stalk; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          47..203
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          304..476
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   941 AA;  106757 MW;  E70ED1F7355BE56D CRC64;
     MEGASRVCRQ GRVALPAEED YLPLKPRVGK AAKEYPFILD AFQREAIQCV DNNQSVLVSA
     HTSAGKTVCA EYAIALALRE KQRVIFTSPI KALSNQKYRE MYEEFQDVGL MTGDVTINPT
     ASCLVMTTEI LRSMLYRGSE VMREVAWVIF DEIHYMRDSE RGVVWEETII LLPDNVHYVF
     LSATIPNARQ FAEWICHLHK QPCHVIYTDY RPTPLQHYIF PAGGDGLHLV VDENGDFRED
     NFNTAMQVLR DAGDLAKGDQ KGRKGGTKGP SNVFKIVKMI MERNFQPVII FSFSKKGCEA
     YALQMTKLDF NTDEEKKMVE EVFSNAIDCL SDEDKKLPQV EHVLPLLKRG IGIHHGGLLP
     ILKETIEILF SEGLIKALFA TETFAMGINM PARTVLFTNA RKFDGKDFRW ISSGEYIQMS
     GRAGRRGMDD RGIVILMVDE KMSPTIGKQL LKGSADPLNS AFHLTYNMVL NLLRVEEINP
     EYMLEKSFYQ FQHYRAIPGV VEKVKNSEEQ YNKIVIPNEE SVVIYYKIRQ QLAKLGKEIE
     EYIHKPKYCL PFLQPGRLVK VKNEGDDFGW GVVVNFSKKS NVKPNSGELD PLYVVEVLLR
     CSKESLKNSA TEAAKPAKPD EKGEMQVVPV LVHLLSAISS VRLYIPKDLR PVDNRQSVLK
     SIQEVQKRFP DGIPLLDPID DMGIQDQGLK KVIQKVEAFE HRMYSHPLHN DPNLETVYTL
     CEKKAQIAID IKSAKRELKK ARTVLQMDEL KCRKRVLRRL GFATSSDVIE MKGRVACEIS
     SADELLLTEM MFNGLFNDLS AEQATALLSC FVFQENSSEM PKLTEQLAGP LRQMQECAKR
     IAKVSAEAKL EIDEETYLSS FKPHLMDVVY TWATGATFAH ICKMTDVFEG SIIRCMRRLE
     ELLRQMCQAA KAIGNTELEN KFAEGITKIK RDIVFAASLY L
//