ID B4EEF0_BURCJ Unreviewed; 334 AA.
AC B4EEF0;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=2-oxoisovalerate dehydrogenase beta subunit {ECO:0000313|EMBL:CAR51515.1};
DE EC=1.2.4.4 {ECO:0000313|EMBL:CAR51515.1};
GN Name=bkdA2 {ECO:0000313|EMBL:CAR51515.1};
GN ORFNames=BCAL1213 {ECO:0000313|EMBL:CAR51515.1};
OS Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 /
OS NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=216591 {ECO:0000313|EMBL:CAR51515.1, ECO:0000313|Proteomes:UP000001035};
RN [1] {ECO:0000313|EMBL:CAR51515.1, ECO:0000313|Proteomes:UP000001035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 /
RC CF5610 {ECO:0000313|Proteomes:UP000001035};
RX PubMed=18931103; DOI=10.1128/JB.01230-08;
RA Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D.,
RA Cerdeno-Tarraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S.,
RA Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K.,
RA Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D.,
RA Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R.,
RA Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J.;
RT "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT cystic fibrosis patients.";
RL J. Bacteriol. 191:261-277(2009).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; AM747720; CAR51515.1; -; Genomic_DNA.
DR AlphaFoldDB; B4EEF0; -.
DR KEGG; bcj:BCAL1213; -.
DR eggNOG; COG0022; Bacteria.
DR HOGENOM; CLU_012907_1_0_4; -.
DR Proteomes; UP000001035; Chromosome 1.
DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:CAR51515.1}.
FT DOMAIN 1..176
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 334 AA; 36450 MW; D695361097A59754 CRC64;
MTMIQALRSA MDVMLGRDSD VVVFGQDVGY FGGVFRCTEG LQNKYGKSRV FDAPISEGGI
VGAAVGMGAY GLRPVCEIQF ADYFYPASDQ IVSEGARLRY RSAGQFTAPM TIRMPCGGGI
YGGQTHSQSP EAMFTQVCGL RTVMPSNPYD AKGLLIASIE NDDPVIFLEP KRLYNGPFDG
HHERPVTSWL KHPASAVPEG YYTVPLDTAA VVRPGNDVTV LTYGTTVHVS LAAAEETGID
AEVIDLRTLW PLDLDTIVAS VRKTGRCVVV HEATRTCGYG AELVSLVQEH CFYHLEAPVE
RTTGWDTPYP HAQEWAYFPG PTRVGEALRR VMEA
//
