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Database: UniProt
Entry: B4ENN1_BURCJ
LinkDB: B4ENN1_BURCJ
Original site: B4ENN1_BURCJ 
ID   B4ENN1_BURCJ            Unreviewed;       614 AA.
AC   B4ENN1;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   SubName: Full=Putative thiamine pyrophosphate enzyme {ECO:0000313|EMBL:CAR57413.1};
GN   ORFNames=BCAS0485 {ECO:0000313|EMBL:CAR57413.1};
OS   Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656
OS   / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=216591 {ECO:0000313|EMBL:CAR57413.1, ECO:0000313|Proteomes:UP000001035};
RN   [1] {ECO:0000313|EMBL:CAR57413.1, ECO:0000313|Proteomes:UP000001035}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 /
RC   CF5610 {ECO:0000313|Proteomes:UP000001035};
RX   PubMed=18931103; DOI=10.1128/JB.01230-08;
RA   Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M.,
RA   Bentley S.D., Cerdeno-Tarraga A.M., Thomson N.R., Bason N.,
RA   Quail M.A., Sharp S., Cherevach I., Churcher C., Goodhead I.,
RA   Hauser H., Holroyd N., Mungall K., Scott P., Walker D., White B.,
RA   Rose H., Iversen P., Mil-Homens D., Rocha E.P., Fialho A.M.,
RA   Baldwin A., Dowson C., Barrell B.G., Govan J.R., Vandamme P.,
RA   Hart C.A., Mahenthiralingam E., Parkhill J.;
RT   "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT   cystic fibrosis patients.";
RL   J. Bacteriol. 191:261-277(2009).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; AM747722; CAR57413.1; -; Genomic_DNA.
DR   RefSeq; WP_006482037.1; NC_011002.1.
DR   ProteinModelPortal; B4ENN1; -.
DR   STRING; 216591.BCAS0485; -.
DR   EnsemblBacteria; CAR57413; CAR57413; BCAS0485.
DR   KEGG; bcj:BCAS0485; -.
DR   eggNOG; ENOG4105C7K; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000258444; -.
DR   KO; K00156; -.
DR   OMA; AANWYAR; -.
DR   OrthoDB; POG091H02KO; -.
DR   Proteomes; UP000001035; Chromosome 3.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1220; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001035};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        3    169       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      198    327       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      390    545       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   614 AA;  66048 MW;  C86D83E5735BEA0D CRC64;
     MATVADFIVE RLYDWGVRRI YGYPGDGING FFGALNRADG KIEFIQARHE EMAAFMASAH
     AKFTGELGVC VATSGPGAAH LVTGLYDARL DHMPVLAIVG QQARAALGGH YQQEVDLPAL
     YKDVAGAFVQ LATVPGQVRH LVDRAVRTAL GARTVTALVL PNDLQELDYA PPKRAHGTVH
     SGVGYTAPKV VPYADDLRRA ADVLNAGSKV ALLVGAGALK ATDEVIAVAD RLGAGAAKAL
     LGKAALPDDL PWVTGSIGLL GTKPSYELMT ECDTLLVVGS GFPYSEFLPK EGQARGVQID
     LKADMLSLRY PMEVNLVGDS AETLRALLPL LNERRDTAWR DRIAKWNHDW HETLAARAAA
     KASAGRGVNP QRAFTELSPR LPDDVILTSD SGSCANWYAR DLMMRRGMMG SLSGGLASMG
     AAVPYAIAAK FAHPVRPVIA MVGDGAMQMN NMAELITVAK YWRQWPDPRW ICMVLNNEDL
     NQVTWEQRVM EGDPKFDASQ QIPNVPYYRF ATLLGLKGIY VDDPEQLGAA WDEALASDRP
     VVLEVKSDPE VPPLPPHVTL QQAKHFAETL VKGDAREANV IVETARQVLS AVLPGNGEHG
     DKAGKGSKGG KGES
//
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