ID BETA_PROMH Reviewed; 555 AA.
AC B4EX94;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 01-MAY-2013, entry version 39.
DE RecName: Full=Choline dehydrogenase;
DE Short=CDH;
DE Short=CHD;
DE EC=1.1.99.1;
GN Name=betA; OrderedLocusNames=PMI1459;
OS Proteus mirabilis (strain HI4320).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Proteus.
OX NCBI_TaxID=529507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HI4320;
RX PubMed=18375554; DOI=10.1128/JB.01981-07;
RA Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA Parkhill J., Mobley H.L.T.;
RT "Complete genome sequence of uropathogenic Proteus mirabilis, a master
RT of both adherence and motility.";
RL J. Bacteriol. 190:4027-4037(2008).
CC -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC reduced acceptor.
CC -!- COFACTOR: FAD (By similarity).
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC via choline pathway; betaine aldehyde from choline (cytochrome c
CC reductase route): step 1/1.
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR EMBL; AM942759; CAR43062.1; -; Genomic_DNA.
DR RefSeq; YP_002151190.1; NC_010554.1.
DR STRING; 529507.PMI1459; -.
DR EnsemblBacteria; CAR43062; CAR43062; PMI1459.
DR GeneID; 6802577; -.
DR KEGG; pmr:PMI1459; -.
DR PATRIC; 20517543; VBIProMir120933_1407.
DR eggNOG; COG2303; -.
DR HOGENOM; HOG000139600; -.
DR KO; K00108; -.
DR OMA; AMDYDGW; -.
DR ProtClustDB; PRK02106; -.
DR BioCyc; PMIR529507:GJIW-1470-MONOMER; -.
DR UniPathway; UPA00529; UER00385.
DR GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:HAMAP.
DR HAMAP; MF_00750; Choline_dehydrogen; 1; -.
DR InterPro; IPR011533; Choline_dehydrogenase.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR TIGRFAMs; TIGR01810; betA; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT CHAIN 1 555 Choline dehydrogenase.
FT /FTId=PRO_1000133334.
FT NP_BIND 4 33 FAD (Potential).
FT ACT_SITE 473 473 By similarity.
SQ SEQUENCE 555 AA; 61595 MW; 759084978ECD3CE1 CRC64;
MVYDYIIIGA GSAGNVLATR LTEDPDVTVL LLEAGGPDYR FDFRTQMPAA LAYPLQGRRY
NWAYETEPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN AMDFDEWAKL PGLEDWNYLN
CLPYFRKAET RDIGANDYHG DSGPVSVTTP KKGNNVLFHA MVEAGVQAGY PRTDDLNGYQ
QEGFGPMDRT VTPHGRRAST ARGYLDQAKS RKNLTIETHA TTDIIEFEGK KASGVRYFKG
TNTTPQHVKA RKEILLCAGA IASPQILQRS GVGPEDVLNE FDISPVHVLP GVGQNLQDHL
EMYLQYECKQ PVSLYPALKW YNQPKIGAEW LFKGTGIGAS NQFEAGGFIR SSEKFAWPNI
QFHFLPVAIN YNGSNAVEVH GFQAHVGSMR SPSRGRIKIT SRDPHQHPSI LFNYMSTEQD
WQEFRAAIRI TREIMAQPAL DPYRGEEISP GKDIQTDEQL DAFVRERAET AFHPCGSCKM
GNDEMAVVDG AGRVHGIESL RVIDASIMPN IITGNLNATT IMIAEKMADK IKGIKPLPAS
QADYYVAGHS PARRN
//
