GenomeNet

Database: UniProt
Entry: B4EX94
LinkDB: B4EX94
Original site: B4EX94 
ID   BETA_PROMH              Reviewed;         555 AA.
AC   B4EX94;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-SEP-2014, entry version 44.
DE   RecName: Full=Oxygen-dependent choline dehydrogenase;
DE            Short=CDH;
DE            Short=CHD;
DE            EC=1.1.99.1;
DE   AltName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betA; OrderedLocusNames=PMI1459;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/JB.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master
RT   of both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
CC   -!- FUNCTION: Involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. Catalyzes the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine at the same rate
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AM942759; CAR43062.1; -; Genomic_DNA.
DR   RefSeq; YP_002151190.1; NC_010554.1.
DR   STRING; 529507.PMI1459; -.
DR   EnsemblBacteria; CAR43062; CAR43062; PMI1459.
DR   GeneID; 6802577; -.
DR   KEGG; pmr:PMI1459; -.
DR   PATRIC; 20517543; VBIProMir120933_1407.
DR   eggNOG; COG2303; -.
DR   HOGENOM; HOG000139600; -.
DR   KO; K00108; -.
DR   OMA; YLQYACT; -.
DR   OrthoDB; EOG67HJQP; -.
DR   BioCyc; PMIR529507:GJIW-1470-MONOMER; -.
DR   UniPathway; UPA00529; UER00385.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00750; Choline_dehydrogen; 1.
DR   InterPro; IPR011533; BetA.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; NAD; Oxidoreductase.
FT   CHAIN         1    555       Oxygen-dependent choline dehydrogenase.
FT                                /FTId=PRO_1000133334.
FT   NP_BIND       4     33       FAD (By similarity).
FT   ACT_SITE    473    473       By similarity.
SQ   SEQUENCE   555 AA;  61595 MW;  759084978ECD3CE1 CRC64;
     MVYDYIIIGA GSAGNVLATR LTEDPDVTVL LLEAGGPDYR FDFRTQMPAA LAYPLQGRRY
     NWAYETEPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN AMDFDEWAKL PGLEDWNYLN
     CLPYFRKAET RDIGANDYHG DSGPVSVTTP KKGNNVLFHA MVEAGVQAGY PRTDDLNGYQ
     QEGFGPMDRT VTPHGRRAST ARGYLDQAKS RKNLTIETHA TTDIIEFEGK KASGVRYFKG
     TNTTPQHVKA RKEILLCAGA IASPQILQRS GVGPEDVLNE FDISPVHVLP GVGQNLQDHL
     EMYLQYECKQ PVSLYPALKW YNQPKIGAEW LFKGTGIGAS NQFEAGGFIR SSEKFAWPNI
     QFHFLPVAIN YNGSNAVEVH GFQAHVGSMR SPSRGRIKIT SRDPHQHPSI LFNYMSTEQD
     WQEFRAAIRI TREIMAQPAL DPYRGEEISP GKDIQTDEQL DAFVRERAET AFHPCGSCKM
     GNDEMAVVDG AGRVHGIESL RVIDASIMPN IITGNLNATT IMIAEKMADK IKGIKPLPAS
     QADYYVAGHS PARRN
//
DBGET integrated database retrieval system