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Database: UniProt
Entry: B4F721
LinkDB: B4F721
Original site: B4F721 
ID   NFL_XENTR               Reviewed;         557 AA.
AC   B4F721;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   16-OCT-2013, entry version 23.
DE   RecName: Full=Neurofilament light polypeptide;
DE            Short=NF-L;
DE   AltName: Full=Neurofilament triplet L protein;
GN   Name=nefl;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Neurofilaments usually contain three intermediate
CC       filament proteins: L, M, and H which are involved in the
CC       maintenance of neuronal caliber.
CC   -!- MISCELLANEOUS: NF-L is the most abundant of the three
CC       neurofilament proteins and, as the other nonepithelial
CC       intermediate filament proteins, it can form homopolymeric 10-nm
CC       filaments (By similarity).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
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DR   EMBL; BC168098; AAI68098.1; -; mRNA.
DR   UniGene; Str.57184; -.
DR   STRING; 8364.ENSXETP00000022374; -.
DR   PaxDb; B4F721; -.
DR   Xenbase; XB-GENE-492106; nefl.
DR   eggNOG; NOG145720; -.
DR   HOGENOM; HOG000230977; -.
DR   GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001664; IF.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   InterPro; IPR018039; Intermediate_filament_CS.
DR   InterPro; IPR027692; NF-L.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   PANTHER; PTHR23239:SF22; PTHR23239:SF22; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   PROSITE; PS00226; IF; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Complete proteome; Intermediate filament;
KW   Reference proteome.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    557       Neurofilament light polypeptide.
FT                                /FTId=PRO_0000373800.
FT   REGION        2     89       Head (By similarity).
FT   REGION       90    392       Rod (By similarity).
FT   REGION       90    121       Coil 1A (By similarity).
FT   REGION      122    134       Linker 1 (By similarity).
FT   REGION      135    230       Coil 1B (By similarity).
FT   REGION      231    248       Linker 12 (By similarity).
FT   REGION      249    267       Coil 2A (By similarity).
FT   REGION      268    276       Linker 2 (By similarity).
FT   REGION      277    392       Coil 2B (By similarity).
FT   REGION      393    557       Tail (By similarity).
FT   REGION      393    437       Tail, subdomain A (By similarity).
FT   REGION      438    557       Tail, subdomain B (acidic) (By
FT                                similarity).
FT   MOD_RES       2      2       N-acetylserine (By similarity).
SQ   SEQUENCE   557 AA;  63115 MW;  BE35CD724D7ED59B CRC64;
     MSSYSYDPYY TSYKRRVVES SPRVHIRSSY VSPSRTTYSP VVSSTMRRSY AASSSSSSSL
     LHGVDTMDLS QVAAISSDLK IVRTQEKAQL QDLNDRFANF IERVHELEQR NKVLEAELLL
     LRQKHNEPSR LRDLYEQEVR ELRLAQEEAT GDRQTMRNER ERLEDALRLL QGRYEEEALS
     REDAEARLLD VRKEADMAAL ARVELEKRMD SLLDEIAFLK KVHEEELAQL QSQVQYAQIS
     LEVEVAKPDL SSALRDIRAQ YEKLAAKNMQ SAEDWFKSRF TVLTQSAARN TDAVRAAKDE
     VSESRRMLSA KGLEIEACRG VNDALERQIQ ELEEKQSGEI AGMQDAINKL EEELRNTKSE
     MARYLKEYQD LLNVKMALDI EIAAYRKLLE GEETRLSFSG VGAITSGYTQ SAPVFGRSAY
     SLQSSSYMTS RAFPTYYSSH VQEEQLDIEE TIESSRAEEA KAEAPEEEEE EAGEEEAEGG
     EGDEGEGEEG EEAKEEEAEE EGEGEEKEEE EEGEGEAEGE AEGEGEAEGE GEEEEEGKGE
     EPAEEESKKK KKKKKKK
//
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