ID NFL_XENTR Reviewed; 557 AA.
AC B4F721;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-APR-2013, entry version 21.
DE RecName: Full=Neurofilament light polypeptide;
DE Short=NF-L;
DE AltName: Full=Neurofilament triplet L protein;
GN Name=nefl;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Neurofilaments usually contain three intermediate
CC filament proteins: L, M, and H which are involved in the
CC maintenance of neuronal caliber.
CC -!- MISCELLANEOUS: NF-L is the most abundant of the three
CC neurofilament proteins and, as the other nonepithelial
CC intermediate filament proteins, it can form homopolymeric 10-nm
CC filaments (By similarity).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
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DR EMBL; BC168098; AAI68098.1; -; mRNA.
DR UniGene; Str.57184; -.
DR STRING; 8364.ENSXETP00000022374; -.
DR PaxDb; B4F721; -.
DR Xenbase; XB-GENE-492106; nefl.
DR eggNOG; NOG145720; -.
DR HOGENOM; HOG000230977; -.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR016044; F.
DR InterPro; IPR001664; IF.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR InterPro; IPR018039; Intermediate_filament_CS.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR PROSITE; PS00226; IF; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Coiled coil; Complete proteome; Intermediate filament;
KW Reference proteome.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 557 Neurofilament light polypeptide.
FT /FTId=PRO_0000373800.
FT REGION 2 89 Head (By similarity).
FT REGION 90 392 Rod (By similarity).
FT REGION 90 121 Coil 1A (By similarity).
FT REGION 122 134 Linker 1 (By similarity).
FT REGION 135 230 Coil 1B (By similarity).
FT REGION 231 248 Linker 12 (By similarity).
FT REGION 249 267 Coil 2A (By similarity).
FT REGION 268 276 Linker 2 (By similarity).
FT REGION 277 392 Coil 2B (By similarity).
FT REGION 393 557 Tail (By similarity).
FT REGION 393 437 Tail, subdomain A (By similarity).
FT REGION 438 557 Tail, subdomain B (acidic) (By
FT similarity).
FT MOD_RES 2 2 N-acetylserine (By similarity).
SQ SEQUENCE 557 AA; 63115 MW; BE35CD724D7ED59B CRC64;
MSSYSYDPYY TSYKRRVVES SPRVHIRSSY VSPSRTTYSP VVSSTMRRSY AASSSSSSSL
LHGVDTMDLS QVAAISSDLK IVRTQEKAQL QDLNDRFANF IERVHELEQR NKVLEAELLL
LRQKHNEPSR LRDLYEQEVR ELRLAQEEAT GDRQTMRNER ERLEDALRLL QGRYEEEALS
REDAEARLLD VRKEADMAAL ARVELEKRMD SLLDEIAFLK KVHEEELAQL QSQVQYAQIS
LEVEVAKPDL SSALRDIRAQ YEKLAAKNMQ SAEDWFKSRF TVLTQSAARN TDAVRAAKDE
VSESRRMLSA KGLEIEACRG VNDALERQIQ ELEEKQSGEI AGMQDAINKL EEELRNTKSE
MARYLKEYQD LLNVKMALDI EIAAYRKLLE GEETRLSFSG VGAITSGYTQ SAPVFGRSAY
SLQSSSYMTS RAFPTYYSSH VQEEQLDIEE TIESSRAEEA KAEAPEEEEE EAGEEEAEGG
EGDEGEGEEG EEAKEEEAEE EGEGEEKEEE EEGEGEAEGE AEGEGEAEGE GEEEEEGKGE
EPAEEESKKK KKKKKKK
//
