ID B4F748_XENTR Unreviewed; 780 AA.
AC B4F748; A0A6I8T291;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Kin of IRRE-like protein 2 precursor {ECO:0000313|RefSeq:NP_001135598.1};
DE SubName: Full=Kirre like nephrin family adhesion molecule 2 {ECO:0000313|Ensembl:ENSXETP00000101765};
GN Name=kirrel2 {ECO:0000313|Ensembl:ENSXETP00000101765,
GN ECO:0000313|RefSeq:NP_001135598.1,
GN ECO:0000313|Xenbase:XB-GENE-854070};
GN Synonyms=filtrin {ECO:0000313|RefSeq:NP_001135598.1}, NEPH1
GN {ECO:0000313|RefSeq:NP_001135598.1}, neph3
GN {ECO:0000313|RefSeq:NP_001135598.1}, nlg1
GN {ECO:0000313|RefSeq:NP_001135598.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI68130.1};
RN [1] {ECO:0000313|RefSeq:NP_001135598.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI68130.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testes {ECO:0000313|EMBL:AAI68130.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000101765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000101765};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000101765}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001135598.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; BC168130; AAI68130.1; -; mRNA.
DR RefSeq; NP_001135598.1; NM_001142126.1.
DR Ensembl; ENSXETT00000070197; ENSXETP00000101765; ENSXETG00000001252.
DR GeneID; 100216155; -.
DR KEGG; xtr:100216155; -.
DR AGR; Xenbase:XB-GENE-854070; -.
DR CTD; 84063; -.
DR Xenbase; XB-GENE-854070; kirrel2.
DR eggNOG; KOG3510; Eukaryota.
DR HOGENOM; CLU_013520_1_2_1; -.
DR OMA; RYEHSYG; -.
DR OrthoDB; 5362512at2759; -.
DR TreeFam; TF327139; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000001252; Expressed in neurula embryo and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd05759; IgI_2_KIRREL3-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF51; KIN OF IRRE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001135598.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..780
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001135598.1"
FT /id="PRO_5033207637"
FT TRANSMEM 492..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 113..217
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 224..303
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 308..388
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 392..486
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 538..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 84379 MW; BDF9F19029AE5E3D CRC64;
MKNLWLLLWI HVGLLLGKSF GAHFSQQPSD KVIVAGKSVT LPCVVIGYRG VVQWTMDGLA
LGAERDLPGW SRYSVVGDPS LGEHNLHIEG VELSDDAIYE CQATQAALRS QRARLTVLLP
PGDPMIPGSP VANVLLNVPY NLTCLAPVAK PAAEITWYRD GKKLDSAVYT KELLSDGKSE
GSASSLLITP SLADSGSSYT CRVRNEALPE GREKSVTLSV QYPPKVTLSV EPPTITEGGS
VTFLCGAVSN PEVTGYRWAK GGVPLAVSGD KYTVEVDHTF FTAPVSCEVS NSVGASNVST
AVNVLFGPRL LTEPRPMTVD IGDDASFFCG WTGNPTPTQF WSKKGTGEVL SNGNTLLLTK
VTREDAGIYV CKAIVPRMGS TEKEVTLTVR GPPIITSEMH YETTLGGKAR MECLIESTPA
PDRIVWAWDK QSLEDGSWGR FSVETEVTEV GAISVLVIDG AEQSDFLTEF NCSAINQYGE
DSVIVSLRQQ AALPLTLLLI AVGSGTLCIF VLVITSILCC RRPKKAVKDT QILAVDVSGS
EPSERHPSDS EEDLKEPLHT DTESQRTSQT EHSDIPDEPQ DPTNGYYKVR AHEDTRPTTI
TYPEFSSPPR PLYSTTSSLS PLCPTPSGPP KIYDYAHRYA TTPRSGGHHM PQGSSSHLPQ
GTTHLPQGPM HLPQVPTHLP QAPTYLPQGP THLPQGPTHL PQGPTHLPHG PSHLQQGLSH
LPPGPSQHSA PYARAFCSYV RPDRFDSMDQ GPALARLSYA SLTTHSDFGR PSQQRMQTHV
//