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Database: UniProt
Entry: B4FFV3_MAIZE
LinkDB: B4FFV3_MAIZE
Original site: B4FFV3_MAIZE 
ID   B4FFV3_MAIZE            Unreviewed;       397 AA.
AC   B4FFV3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 106.
DE   RecName: Full=Malate dehydrogenase {ECO:0000256|ARBA:ARBA00012995, ECO:0000256|RuleBase:RU003405};
DE            EC=1.1.1.37 {ECO:0000256|ARBA:ARBA00012995, ECO:0000256|RuleBase:RU003405};
GN   Name=100193663 {ECO:0000313|EnsemblPlants:Zm00001eb179730_P001};
GN   ORFNames=ZEAMMB73_Zm00001d050409 {ECO:0000313|EMBL:AQK52494.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:ACF80996.1};
RN   [1] {ECO:0000313|EMBL:ACF80996.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B73 {ECO:0000313|EMBL:ACF80996.1};
RX   PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA   Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA   Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA   Walbot V., Yu Y.;
RT   "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL   PLoS Genet. 5:E1000740-E1000740(2009).
RN   [2] {ECO:0000313|EnsemblPlants:Zm00001eb179730_P001, ECO:0000313|Proteomes:UP000007305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb179730_P001,
RC   ECO:0000313|Proteomes:UP000007305};
RX   PubMed=19965430; DOI=10.1126/science.1178534;
RA   Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA   Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA   Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA   Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA   Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA   Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA   Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA   Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA   Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA   Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA   Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA   Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA   Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA   Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA   Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA   Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA   Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA   Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA   Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA   Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA   SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA   Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA   Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA   Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA   Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA   Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT   "The B73 maize genome: complexity, diversity, and dynamics.";
RL   Science 326:1112-1115(2009).
RN   [3] {ECO:0000313|EMBL:AQK52494.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Seedling {ECO:0000313|EMBL:AQK52494.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EnsemblPlants:Zm00001eb179730_P001}
RP   IDENTIFICATION.
RC   STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb179730_P001};
RG   EnsemblPlants;
RL   Submitted (MAY-2021) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate;
CC         Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37;
CC         Evidence={ECO:0000256|RuleBase:RU003405};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.
CC       {ECO:0000256|ARBA:ARBA00008824}.
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DR   EMBL; BT035991; ACF80996.1; -; mRNA.
DR   EMBL; BT066697; ACN33594.1; -; mRNA.
DR   EMBL; CM000780; AQK52494.1; -; Genomic_DNA.
DR   RefSeq; NP_001132228.1; NM_001138756.1.
DR   RefSeq; XP_008676574.1; XM_008678352.1.
DR   RefSeq; XP_008676575.1; XM_008678353.1.
DR   RefSeq; XP_008676576.1; XM_008678354.1.
DR   RefSeq; XP_008676577.1; XM_008678355.1.
DR   AlphaFoldDB; B4FFV3; -.
DR   SMR; B4FFV3; -.
DR   IntAct; B4FFV3; 1.
DR   STRING; 4577.B4FFV3; -.
DR   PaxDb; 4577-GRMZM2G068455_P03; -.
DR   EnsemblPlants; Zm00001eb179730_T001; Zm00001eb179730_P001; Zm00001eb179730.
DR   EnsemblPlants; Zm00001eb179730_T002; Zm00001eb179730_P002; Zm00001eb179730.
DR   EnsemblPlants; Zm00001eb179730_T003; Zm00001eb179730_P003; Zm00001eb179730.
DR   EnsemblPlants; Zm00001eb179730_T004; Zm00001eb179730_P004; Zm00001eb179730.
DR   GeneID; 100193663; -.
DR   Gramene; Zm00001eb179730_T001; Zm00001eb179730_P001; Zm00001eb179730.
DR   Gramene; Zm00001eb179730_T002; Zm00001eb179730_P002; Zm00001eb179730.
DR   Gramene; Zm00001eb179730_T003; Zm00001eb179730_P003; Zm00001eb179730.
DR   Gramene; Zm00001eb179730_T004; Zm00001eb179730_P004; Zm00001eb179730.
DR   KEGG; zma:100193663; -.
DR   eggNOG; KOG1494; Eukaryota.
DR   HOGENOM; CLU_047181_0_0_1; -.
DR   InParanoid; B4FFV3; -.
DR   OMA; CIVECAY; -.
DR   OrthoDB; 5059897at2759; -.
DR   Proteomes; UP000007305; Chromosome 4.
DR   ExpressionAtlas; B4FFV3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   CDD; cd01337; MDH_glyoxysomal_mitochondrial; 1.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR001252; Malate_DH_AS.
DR   InterPro; IPR010097; Malate_DH_type1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR01772; MDH_euk_gproteo; 1.
DR   PANTHER; PTHR11540; MALATE AND LACTATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11540:SF16; MALATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00068; MDH; 1.
PE   1: Evidence at protein level;
KW   NAD {ECO:0000256|RuleBase:RU003405};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003369};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B4FFV3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW   ECO:0000256|RuleBase:RU003405}.
FT   DOMAIN          77..219
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          221..387
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
SQ   SEQUENCE   397 AA;  41617 MW;  875711B26CC366FE CRC64;
     MASTVTFNPV SAQAALIQKP RNLGAISYAG LKMPASVSSG SESSFLGWNA SLRAAVTPRI
     VPKTKSGSQI SPQASYKVAV LGAAGGIGQP LGLLVKMSPL VSELHLYDIA NVKGVAADLS
     HCNTPAQVLD FTGPSELANC LKGVDVVVIP AGVPRKPGMT RDDLFNINAS IVKTLVEAVA
     DSCPEAFIHI ISNPVNSTVP IAAEVLKQKG VYNPKKLFGV TTLDVVRANT FVAQKKNLKL
     IDVDVPVVGG HAGITILPLL SKTRPSVTFT DEETEELTKR IQNAGTEVVD AKAGAGSATL
     SMAYAAARFV ESSLRALAGD PDVYECTFVQ SEITDLPFFA SRVKLGKNGV ESVISADLQG
     MTEYEAKALE ALKAELKASI EKGIAFVNKQ REAAASV
//
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