ID B4FTR6_MAIZE Unreviewed; 339 AA.
AC B4FTR6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=3'-5' exonuclease domain-containing protein / K homology domain-containing protein / KH domain-containing protein {ECO:0000313|EMBL:AQK96120.1};
GN Name=100273227 {ECO:0000313|EnsemblPlants:Zm00001eb356940_P001};
GN ORFNames=ZEAMMB73_Zm00001d011188 {ECO:0000313|EMBL:AQK96120.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ACF85509.1};
RN [1] {ECO:0000313|EMBL:ACF85509.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B73 {ECO:0000313|EMBL:ACF85509.1};
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [2] {ECO:0000313|EnsemblPlants:Zm00001eb356940_P001, ECO:0000313|Proteomes:UP000007305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb356940_P001,
RC ECO:0000313|Proteomes:UP000007305};
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [3] {ECO:0000313|EMBL:AQK96120.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Seedling {ECO:0000313|EMBL:AQK96120.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EnsemblPlants:Zm00001eb356940_P001}
RP IDENTIFICATION.
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb356940_P001};
RG EnsemblPlants;
RL Submitted (MAY-2021) to UniProtKB.
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DR EMBL; BT040504; ACF85509.1; -; mRNA.
DR EMBL; CM000784; AQK96120.1; -; Genomic_DNA.
DR RefSeq; NP_001141141.1; NM_001147669.1.
DR AlphaFoldDB; B4FTR6; -.
DR SMR; B4FTR6; -.
DR IntAct; B4FTR6; 21.
DR STRING; 4577.B4FTR6; -.
DR PaxDb; 4577-GRMZM2G142984_P02; -.
DR EnsemblPlants; Zm00001eb356940_T001; Zm00001eb356940_P001; Zm00001eb356940.
DR GeneID; 100273227; -.
DR Gramene; Zm00001eb356940_T001; Zm00001eb356940_P001; Zm00001eb356940.
DR KEGG; zma:100273227; -.
DR eggNOG; KOG2405; Eukaryota.
DR HOGENOM; CLU_054118_0_0_1; -.
DR InParanoid; B4FTR6; -.
DR OMA; IFIVTHE; -.
DR OrthoDB; 5474641at2759; -.
DR Proteomes; UP000007305; Chromosome 8.
DR ExpressionAtlas; B4FTR6; baseline and differential.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06148; Egl_like_exo; 1.
DR CDD; cd00105; KH-I; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR46814:SF1; 3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN _ K HOMOLOGY DOMAIN-CONTAINING PROTEIN _ KH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46814; EGALITARIAN, ISOFORM B; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00013; KH_1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 1: Evidence at protein level;
KW Exonuclease {ECO:0000313|EMBL:AQK96120.1};
KW Hydrolase {ECO:0000313|EMBL:AQK96120.1};
KW Nuclease {ECO:0000313|EMBL:AQK96120.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B4FTR6};
KW Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 29..222
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT DOMAIN 269..337
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 38107 MW; 811005905EAC6DA2 CRC64;
MASHHSEPLD PADADDPSDN NPELPCPSYH IVTKPGQLPV EFLEPSAAQK LVIGFDCEGV
DLCRNGALCI MQLAFPDAVY LVDAIEGGKE LIQACKPALE SDHITKVIHD CKRDSEALYF
QFGIKLHNVM DTQIAYSLIE EQEQEGKKMT SDDYNYISFV SLLADKRYCG ILYPEKEEVR
TLLRQDPNFW TIRPLSDMMV RAATDDVRFL LSIYAKMMEK LSKVSLWRLA VRSELYCRCF
CLSDNQFADW SPLPPVPDDI EADVYVPEAD ILSVLDVPPG KMGRVIGRKG STIMAVKECC
KVEIHIGGAK GPPDRVFIIG PEKEVRKAEA IFRGRMLEF
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