ID CIAO1_DROPE Reviewed; 335 AA.
AC B4GDM7;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN Name=Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=GL10827;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC protein assembly machinery. Required for the maturation of
CC extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW31684.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CH479181; EDW31684.1; ALT_FRAME; Genomic_DNA.
DR RefSeq; XP_002015794.1; XM_002015758.1.
DR AlphaFoldDB; B4GDM7; -.
DR SMR; B4GDM7; -.
DR STRING; 7234.B4GDM7; -.
DR eggNOG; KOG0645; Eukaryota.
DR OrthoDB; 5486866at2759; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19920:SF0; CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED; 1.
DR PANTHER; PTHR19920; WD40 PROTEIN CIAO1; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..335
FT /note="Probable cytosolic iron-sulfur protein assembly
FT protein Ciao1"
FT /id="PRO_0000382488"
FT REPEAT 12..51
FT /note="WD 1"
FT REPEAT 57..96
FT /note="WD 2"
FT REPEAT 101..140
FT /note="WD 3"
FT REPEAT 146..185
FT /note="WD 4"
FT REPEAT 192..231
FT /note="WD 5"
FT REPEAT 250..289
FT /note="WD 6"
FT REPEAT 301..335
FT /note="WD 7"
SQ SEQUENCE 335 AA; 37053 MW; 3639BC3B9A8A71F7 CRC64;
MGRLILEHTL QGHKGRIWGV AWHPKGNVFA SCGEDKAIRV WSLSGNTWST KTILSDGHKR
TIREIRWSPC GQYLASASFD ATTAIWSKSS GEFECNATLE GHENEVKSVS WSRSGGLLAT
CSRDKSVWIW EVAGDDEFEC AAVLNAHTQD VKRVVWHPTK DILASASYDN TIKMFAESQL
DSDWDCTATL SSHTSTVWSI DFDAEGDRLV SCSDDKTLKI WRAYHPGNDA GIATPDKQSV
WKCVCTLSGQ HSRAIYDVSW CKLTGLIATG CGDDGIRIFK ETSDSKRDEP TFEQLTAEET
AHEQDVNAVE WNPAVAGQLI SCSDDGTIKI WKVAD
//
