ID B4H795_DROPE Unreviewed; 3001 AA.
AC B4H795;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=GL13243 {ECO:0000313|EMBL:EDW33701.1};
GN Name=Dper\GL13243 {ECO:0000313|EMBL:EDW33701.1};
GN ORFNames=Dper_GL13243 {ECO:0000313|EMBL:EDW33701.1};
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234 {ECO:0000313|Proteomes:UP000008744};
RN [1] {ECO:0000313|EMBL:EDW33701.1, ECO:0000313|Proteomes:UP000008744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49
RC {ECO:0000313|Proteomes:UP000008744};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CH479217; EDW33701.1; -; Genomic_DNA.
DR RefSeq; XP_002026724.1; XM_002026688.1.
DR STRING; 7234.B4H795; -.
DR EnsemblMetazoa; FBtr0178858; FBpp0177350; FBgn0150849.
DR eggNOG; KOG3627; Eukaryota.
DR HOGENOM; CLU_226101_0_0_1; -.
DR OMA; SHELHTY; -.
DR PhylomeDB; B4H795; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR015420; Peptidase_S1A_nudel.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF67; PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1-LIKE PROTEIN; 1.
DR Pfam; PF09342; DUF1986; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008744};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1021..1061
FT /note="Peptidase S1A nudel"
FT /evidence="ECO:0000259|Pfam:PF09342"
FT REGION 203..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1495..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1597..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1706..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1817..2006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2029..2059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2309..2357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2413..2437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2470..2498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2580..2608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2646..2665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2912..2933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2967..3001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1170
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1514..1552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1843..1901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1922..1940
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1965..1994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2414..2428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2586..2608
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 738..753
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 776..791
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 3001 AA; 333330 MW; 379704CECF6ECAF5 CRC64;
MTYSMDDLEA TRLLRSPRYW CARTPNKRVL AITVLVILAM FLMLIYHGIV VERMDRVQQI
AALNEKHRQF KEPVHEDKDV LIVSPQTLHV NFKTGGQSAG MNERQSRLNS LRWKFRLYNK
RRVPRDLSRS DILDPLQVEA NMQQIYSKLR SKRARQALSL LESEYVRCKK QTPHDCMSAF
VRMYNMAKEI TEKMEKMKAI MRAQQPQLES GSMESNETRE KTQESTAGPT TSAANITEET
SSQKPVRSKI KPARISWIID GHDHDDSAVY TDNTPKSLTT KEPMNTTLPL VETTTPQATV
EETSPSSVGP SEVIVGTTTE QISWILDRFD KPKEIVHTTE GPRQRTTREL TTTAAAPNSG
LEHTSENVVW ETKLTTDAPE ALSTTTPAVA HNETVPRKLQ FDWIIDGEEV VEPEPEMGNS
SATATTTQAT VSTTDASDAH NFTAYPTKPK PVKISWIIDS DVISAEVSST TSQPKLTTTT
ETPTTEKGSR IPGHPLDNPS SIENMLESFE RHEPEKPIIK VLSSNESSED TVTDLYERQH
WLKKFEAQAM ETKDELIDTF GTALDAKVLD KMGPKINPLN GHLLNDHQCR PLCHQLCEIL
LRGACWTPAS FQLLSCHPDP ASVPCGRPPG LRKAEHAKRS VVVATCQSAA LQSLGEAHLS
ARPGKDDLRR RLDMGSRGAH PLHGGGMGSH QGEGSKQMAQ IVELQMRCDR KVDCEDGTDE
LGCSCRDYMK GSLRALICDG KPDCEDLTDE QDCVGCKTNE FRCPLSKTCL PMSKRCDKKA
DCQFKEDEKD CFALTNGQDV HFDVHQQPKF SSAGIFSKNA HGVWRVVCAH ETGYHEHQAN
TADAVCALLG FKGAHYFNSS EIVSQRDVHP ITPELPGKTQ LVVELRSMDN DNDQLSENEE
AMPEQGLLSP SRPEKDRLLP STCLGIYVEC NPLSNQTTPL KTLSAGQAVK QKPAEQMPIL
LPTIETHNRP NVHFKPQVPA TMIVNKKDEV LDRLDNLIKS KKNKTLLVNE QLHEAIEELH
WPWLADVYAN GELWCLGVLI DKHWLLVHES CLSGIRGKES YSYQHNYVDR VRLEDTNGGH
QHHHSHYHNS SSSTSNVHDP RCPQGLRAAA AGWRHTHKSV SHLDLATSCH EAAGNGIGRH
TQHHPHGHHS HPHHLQHAHH AHHSHHPHAQ PHWTQCRVGL GGAGAAGGGP GSGQLRNARS
LDYTQLEREE NALDIAEFYW RFDAEAPLDH GDSYAVLPVN DNFEATPAAP AAAGEPPATS
STVNGGTTAS ATATATATAT ATAAATLFDL LGSESCSLRR SRSLAVIREE TFSDLQIGSA
NSSRRRSQLI PRARLVNRGF FRESPRLNAK QQQQQTTSST IEQPLETPPA DDTQSHRSSN
NSGTCDSHQQ QQQQQQQQQQ QAHPRGRGES RDFDLYYDNL KRLDALALGL SEQLHPWHND
KSDLESLNSD YFKNSLHQNH LEQQQQQQGP SSLEFEALEQ AAVNLLKERP RIYQSRRQQQ
QRNHHHHQCH LQRHLQQDTG GESCPEHSQS SVFPETTTSN SDDQTDSPSL SEQEYDLTHI
EEIYQQQAGG VGVAVAVGAN GVEESYEIIS LTTTARTTRF EESCSDQEAD DDQEGADHVE
EESRLTPTSG EIPASDSDST LKRGHGEHLI AYDSVYLSSE DSSDCTLIGE SCESFEQRTF
TSCGESGELE TRSLLHISIE DTVYEPQAKH HKKGGASEEQ QQQQQPLLTT AKVEAQIFTQ
VLKVEHTPQN KPKILAVVEK RKLKQEEAQG KQQQQPATDS FVVVSNLQEN QYHSLPDVNI
GVSLKVCESI DKELRSSYNQ QRQQQRKDSK RGAQVVTRAE TYDSIRRFGR AHQKARQKEH
QERERERERE AAAAAGGEKE AQRQEKPKIT KEIVAAEEPQ RQQEPEEEEE PPLPPPPPPL
TEEEQQEEEP QAEEEPEPEP EPVSIAQVEQ PKEAPVIEVA NFSKLIERRA QEIRERKDPD
GRQEQRRQQQ QPQEEAEQEG EAEGEAEGET LFHIIVTDAQ NNIIEKEAIH EEHSLQRPRT
VRRSQSSSCG KPPERRILHS GGAPIYKARP IKVLAAGHSH GESTFGRGKM SRPQILHVVD
GGAAAEGSLR RRSSARSIAS TVSGAGGAAV ATEYLQKVDA VRCYWQKLAG NEPETPAADT
DKGEAEGCKG LQFQLGGKTT ALQQQQLLQP LQPLQLHSKD FCSMMPPPSI EIVELGEGAQ
KETIVSAAPD PDADEDDQDE AQFDHIRYKV LKSQQVIRSN ILHHSTRNKK EAQFDGLIQY
LQDYSFQELL SNNNVVIVEP VRTKIERPLQ VGGGPAPRVA AAGPPKPPRV IHASGSQPRR
TTLRQRQMGG RWRRGRAPRP KRHFFYQPVR VNPRAVRGRA ARSGHSCGMC VASSSRIVMP
VAGAGPPSCS RSRMFGGSAL STESQGQPGR ARSRDRRTEY LTDRHELWRR LPPSSGRGAA
QGPWNLLAGV RSSSHQQQKH SKLGATGNTG QSSRAGISRR STLELLPCRR LANPARESVD
PLIGPCKDVH VQDVVRRHNS NAANAKARAK FASRRTWCMG GASATSDSLY RQIYEQNLGH
DAEDEQEEGH YDEEEEEDDD EDEEQAHEQD MCENYYVSND ILAKIRECGS TVTYYGGRVL
DGGPASKMSP PQAAAAAAQQ TNGGTRSRIR QIEACNVCLP SERCEHRLQT KQSLEEQQQQ
SQDSYQGIKF KLVKSNSCSS RLELAGADTE VNGGAADSEV VRKMVHHFEA TATDPVTINS
QITEAAAPPR RLQVTVNNHI NVQAVHRNES SNGGSHSAGA EATEISHPTY ESQAMNIRLD
VARGSASSAS KVCRNKNVDL AYTLAKQPTP QARACPALEG NQRLPQNEDV AVSKVVSKQQ
TPAAAAINGS GSGSGRPQII VPVEIHQQIQ QQVAGPLPSA APERRLSNAS SSAASIVDKT
VVRHYVANDR SIYERRKYDE IEFEEFEVYD PSKEPQEGRQ EGRQERPPTD AELYDSLDDK
M
//
