ID B4H8W2_DROPE Unreviewed; 2481 AA.
AC B4H8W2;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 06-MAR-2013, entry version 35.
DE SubName: Full=GL24734;
GN Name=GL24734; Synonyms=Dper\GL24734; ORFNames=Dper_GL24734;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Contains 1 FAT domain.
CC -!- SIMILARITY: Contains 1 FATC domain.
CC -!- SIMILARITY: Contains 1 PI3K/PI4K domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; CH479225; EDW35171.1; -; Genomic_DNA.
DR RefSeq; XP_002027291.1; XM_002027255.1.
DR EnsemblMetazoa; FBtr0190349; FBpp0188841; FBgn0162322.
DR GeneID; 6602261; -.
DR KEGG; dpe:Dper_GL24734; -.
DR FlyBase; FBgn0162322; Dper\GL24734.
DR KO; K07203; -.
DR OrthoDB; EOG4XWDCK; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008144; F:drug binding; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR Gene3D; 1.10.1070.11; -; 3.
DR Gene3D; 1.25.10.10; -; 6.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024585; DUF3385_TOR.
DR InterPro; IPR003152; FATC.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR009076; Rapamycin-bd_dom.
DR InterPro; IPR026683; TOR/Smg1.
DR InterPro; IPR013026; TPR-contain_dom.
DR InterPro; IPR011990; TPR-like_helical.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11139:SF9; PTHR11139:SF9; 1.
DR Pfam; PF11865; DUF3385; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08771; Rapamycin_bind; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM-type_fold; 1.
DR SUPFAM; SSF47212; FRAP_FKBP12_bind; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW Transferase.
SQ SEQUENCE 2481 AA; 282282 MW; 59890974A92CC27C CRC64;
MSTSSVVQNF VNGLKSRNRN VQNKAAQDLF LYVKTELREM SQEELAQFFD EFDHHIFNMV
NAADINEKKG GALAMKCLIT SDGLTTRKGI SPYLNRLRDL LLINDVSVME IAARSLVKLA
NMPGSKGADS FDFDIKKAFE MLSGDRQEYR RHAAVFILRE LAIALPTYFY QQILTFFEHI
FNAIFDPKPA IRESAGEALR AALIVTAQRE NTKQSSEPQW YKICYDEASA SFNQDVATGK
EQKGMTRDDR IHGGLIVFNE LFRCANASWE RRYTALKTLF PKAHHNKFLE ASSHSSMSSQ
LNTFVPRLKV PFIDKLGSTQ MHMEAEHHHN GMAKFASHNV LESAYAHEIL QAHYTTICDN
VLEQRFSKSP YVQQALLQIL PRLAAFNREV FVDKYLQICV PHLMQILRGK EKDRTVAYIT
IGYLAVAVES AIEKYLETIM SCVKMALPAK DLASSKRKAP VDPAVFACIT LLAHAVRSEI
VKDVRDILEQ MFSTGLSPAL TVCLRELSEN VPQLKSGITD GLIGVLSQVL MNKPAAIPYA
ALPPIAIDGS LIMQMADGGT TVLALKTLGT FNFEEQNMLD FVQRCADYFI VHEQQEIRLE
AVQTCTRLLK LAVQSAESME NSKTLSDTVS HVIERLLMVA ITDMDCNVRI RILRSLDETF
DAKLAQPESL NSLFITLHDE IFEIRELAMV TIGRLSSMNP AYVMPKLRTT MIELLTDLKY
SGMNRNKEQS ARMLDHLVIS TPRLISSYMN PILKALVPKL HEPESNPGVI LNVLRTIGDL
AEVNGGSNEM ELWADDLLSI LLEMLGDAGS PDKRGVALWT LGQLISATGR VVSPYHKYPV
LIDILINFLK TEQRRSIRRE TIRVLGLLGA MDPYKHKMNK GLIDSQKDNV LIAYSDGKVD
ESQDISTAEL LVNMGNALDE YYPAVAIAAL MRILRDPTLS TRHTSVVQAV TFIFQSLGIK
CVPYLAQVLP NLLDNVRTAD NNLREFLFQQ LAILVAFVKL HIISYMSDIF KLIKEFWTIN
TPLQSTLINL IEQIAVALGC EFRDYLAELI PQILRVLQHD NSKDRMVTRR LLQALQKFGS
TLGYYLPLIV PPIVKLFDSP YVPQQVSLVA LETINNLACQ LDFTDFSSRI IHPLVRVLDT
EPELRDQAMT TLRSLVKQLG KKYLVFVPMV QRILTKHRIG DSEYDKLLIR LQNNSTLADA
CGSGEFGLRQ AKIKYNEPFV TDRNSNNRNL QVSTNVLRTA WQVTRRVSKD DWVEWLKRLS
IGLLKESPSH ALRACCSLAQ EYDTLLRDLF NAAFISCWTE LSPEHKHELT QSLIQALQVT
DMPEITQTIL NLAEFMEHCD RDPIPIETNL LGTRAMACRA YAKALRYKEE EFLLKEEASV
FESLILINNK LQQREAAEGL LTTYRNAANE LNVQGRWYEK LHNWDQALEH YERNLQTDSS
DLEARLGHMR CLEALGDWSE LSQVTKREWE GFGTEARARA SPLAAVAAWG LQDWEAMREY
VRCIPEDTQD GSYYRAVLAV HHDDFETAQR LIDETRDLLD TELTSMAGES YERAYGAMVC
VQMLAELEEV IQYKLIPERR EPLKTMWWKR LQGGQRLVED WRRIIQVHSL VVKPHDDIHT
WLKYASLCRK SGSLHLSHKT LVMLLGTDPK LNPDEKLPCN QPQVTFAYTK YMAASNQLQE
AYDQLRCFVD KYSTELSCLP PEAVKPQDQR LMARCYLRLA TWQNKLQERL CPGAIQGDLE
CFEKATSYDP NWYKAWHRWA YMNFKVVQAQ KTALDKQQAS LPPGLNIGIG LSMDSDMLII
QQYAVPAVQG FFRSISLIKG NSLQDTLRLL TLWFDYGNHA EVYDALMSGM KLIEINTWLQ
VIPQLIARID THRQLVGQLI HQLLMDIGKN HPQALVYPLT VASKSASLAR RNAAFKILDS
MRKHSPTLVE QAVMCSEELI RVAILWHEQW HEGLEEASRL YFGDRNVKGM FEILEPLHAM
LERGPQTLKE TSFSQAYGRE LTEAYEWSQR YKTSAVVMDL DRAWDIYYHV FQKISRQLPQ
LTSLELPYVS PKLMTCKDLE LAVPGSYNPG QELIRISHIK TNLQVITSKQ RPRKLCIRGS
NGKDYMYLLK GHEDLRQDER VMQLFSLVNT LLLDDPDTFR RNLAIQRYAV IPLSTNSGLI
GWVPHCDTLH TLIRDYRDKK KVPLNQEHRT MLNFAPDYDH LTLMQKVEVF EYALGQTQGD
DLAKLLWLKS PSSELWFERR NNYTRSLAVM SMVGYILGLG DRHPSNLMLD RMSGKILHID
FGDCFEVAMT REKFPEKIPF RLTRMLIKAM EVTGIEGTYR RTCESVMLVL RRNKDSLMAV
LEAFVYDPLL NWRLLDVDKK GNDAAGANGG GAAGRGGSGM QVGNSGDSLS NSVEDSLPMA
KSKTYEAQLL LQQAGGLHNN VADETNSKAS QVIKRVKCKL TGTDFQTQKS VNEQQQVELL
IQQATNNENL CQCYIGWCPF W
//
