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Database: UniProt
Entry: B4H8W2_DROPE
LinkDB: B4H8W2_DROPE
Original site: B4H8W2_DROPE 
ID   B4H8W2_DROPE            Unreviewed;      2481 AA.
AC   B4H8W2;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   11-DEC-2013, entry version 40.
DE   SubName: Full=GL24734;
GN   Name=Dper\GL24734; ORFNames=Dper_GL24734, GL24734;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Contains FAT domain.
CC   -!- SIMILARITY: Contains FATC domain.
CC   -!- SIMILARITY: Contains PI3K/PI4K domain.
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DR   EMBL; CH479225; EDW35171.1; -; Genomic_DNA.
DR   RefSeq; XP_002027291.1; XM_002027255.1.
DR   EnsemblMetazoa; FBtr0190349; FBpp0188841; FBgn0162322.
DR   GeneID; 6602261; -.
DR   KEGG; dpe:Dper_GL24734; -.
DR   FlyBase; FBgn0162322; Dper\GL24734.
DR   KO; K07203; -.
DR   OrthoDB; EOG7CCBQ4; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008144; F:drug binding; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR   Gene3D; 1.10.1070.11; -; 3.
DR   Gene3D; 1.25.10.10; -; 6.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024585; DUF3385_TOR.
DR   InterPro; IPR003152; FATC.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR009076; Rapamycin-bd_dom.
DR   InterPro; IPR026683; TOR.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11139:SF9; PTHR11139:SF9; 1.
DR   Pfam; PF11865; DUF3385; 1.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF08771; Rapamycin_bind; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF47212; SSF47212; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF56112; SSF56112; 2.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   4: Predicted;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Transferase.
SQ   SEQUENCE   2481 AA;  282282 MW;  59890974A92CC27C CRC64;
     MSTSSVVQNF VNGLKSRNRN VQNKAAQDLF LYVKTELREM SQEELAQFFD EFDHHIFNMV
     NAADINEKKG GALAMKCLIT SDGLTTRKGI SPYLNRLRDL LLINDVSVME IAARSLVKLA
     NMPGSKGADS FDFDIKKAFE MLSGDRQEYR RHAAVFILRE LAIALPTYFY QQILTFFEHI
     FNAIFDPKPA IRESAGEALR AALIVTAQRE NTKQSSEPQW YKICYDEASA SFNQDVATGK
     EQKGMTRDDR IHGGLIVFNE LFRCANASWE RRYTALKTLF PKAHHNKFLE ASSHSSMSSQ
     LNTFVPRLKV PFIDKLGSTQ MHMEAEHHHN GMAKFASHNV LESAYAHEIL QAHYTTICDN
     VLEQRFSKSP YVQQALLQIL PRLAAFNREV FVDKYLQICV PHLMQILRGK EKDRTVAYIT
     IGYLAVAVES AIEKYLETIM SCVKMALPAK DLASSKRKAP VDPAVFACIT LLAHAVRSEI
     VKDVRDILEQ MFSTGLSPAL TVCLRELSEN VPQLKSGITD GLIGVLSQVL MNKPAAIPYA
     ALPPIAIDGS LIMQMADGGT TVLALKTLGT FNFEEQNMLD FVQRCADYFI VHEQQEIRLE
     AVQTCTRLLK LAVQSAESME NSKTLSDTVS HVIERLLMVA ITDMDCNVRI RILRSLDETF
     DAKLAQPESL NSLFITLHDE IFEIRELAMV TIGRLSSMNP AYVMPKLRTT MIELLTDLKY
     SGMNRNKEQS ARMLDHLVIS TPRLISSYMN PILKALVPKL HEPESNPGVI LNVLRTIGDL
     AEVNGGSNEM ELWADDLLSI LLEMLGDAGS PDKRGVALWT LGQLISATGR VVSPYHKYPV
     LIDILINFLK TEQRRSIRRE TIRVLGLLGA MDPYKHKMNK GLIDSQKDNV LIAYSDGKVD
     ESQDISTAEL LVNMGNALDE YYPAVAIAAL MRILRDPTLS TRHTSVVQAV TFIFQSLGIK
     CVPYLAQVLP NLLDNVRTAD NNLREFLFQQ LAILVAFVKL HIISYMSDIF KLIKEFWTIN
     TPLQSTLINL IEQIAVALGC EFRDYLAELI PQILRVLQHD NSKDRMVTRR LLQALQKFGS
     TLGYYLPLIV PPIVKLFDSP YVPQQVSLVA LETINNLACQ LDFTDFSSRI IHPLVRVLDT
     EPELRDQAMT TLRSLVKQLG KKYLVFVPMV QRILTKHRIG DSEYDKLLIR LQNNSTLADA
     CGSGEFGLRQ AKIKYNEPFV TDRNSNNRNL QVSTNVLRTA WQVTRRVSKD DWVEWLKRLS
     IGLLKESPSH ALRACCSLAQ EYDTLLRDLF NAAFISCWTE LSPEHKHELT QSLIQALQVT
     DMPEITQTIL NLAEFMEHCD RDPIPIETNL LGTRAMACRA YAKALRYKEE EFLLKEEASV
     FESLILINNK LQQREAAEGL LTTYRNAANE LNVQGRWYEK LHNWDQALEH YERNLQTDSS
     DLEARLGHMR CLEALGDWSE LSQVTKREWE GFGTEARARA SPLAAVAAWG LQDWEAMREY
     VRCIPEDTQD GSYYRAVLAV HHDDFETAQR LIDETRDLLD TELTSMAGES YERAYGAMVC
     VQMLAELEEV IQYKLIPERR EPLKTMWWKR LQGGQRLVED WRRIIQVHSL VVKPHDDIHT
     WLKYASLCRK SGSLHLSHKT LVMLLGTDPK LNPDEKLPCN QPQVTFAYTK YMAASNQLQE
     AYDQLRCFVD KYSTELSCLP PEAVKPQDQR LMARCYLRLA TWQNKLQERL CPGAIQGDLE
     CFEKATSYDP NWYKAWHRWA YMNFKVVQAQ KTALDKQQAS LPPGLNIGIG LSMDSDMLII
     QQYAVPAVQG FFRSISLIKG NSLQDTLRLL TLWFDYGNHA EVYDALMSGM KLIEINTWLQ
     VIPQLIARID THRQLVGQLI HQLLMDIGKN HPQALVYPLT VASKSASLAR RNAAFKILDS
     MRKHSPTLVE QAVMCSEELI RVAILWHEQW HEGLEEASRL YFGDRNVKGM FEILEPLHAM
     LERGPQTLKE TSFSQAYGRE LTEAYEWSQR YKTSAVVMDL DRAWDIYYHV FQKISRQLPQ
     LTSLELPYVS PKLMTCKDLE LAVPGSYNPG QELIRISHIK TNLQVITSKQ RPRKLCIRGS
     NGKDYMYLLK GHEDLRQDER VMQLFSLVNT LLLDDPDTFR RNLAIQRYAV IPLSTNSGLI
     GWVPHCDTLH TLIRDYRDKK KVPLNQEHRT MLNFAPDYDH LTLMQKVEVF EYALGQTQGD
     DLAKLLWLKS PSSELWFERR NNYTRSLAVM SMVGYILGLG DRHPSNLMLD RMSGKILHID
     FGDCFEVAMT REKFPEKIPF RLTRMLIKAM EVTGIEGTYR RTCESVMLVL RRNKDSLMAV
     LEAFVYDPLL NWRLLDVDKK GNDAAGANGG GAAGRGGSGM QVGNSGDSLS NSVEDSLPMA
     KSKTYEAQLL LQQAGGLHNN VADETNSKAS QVIKRVKCKL TGTDFQTQKS VNEQQQVELL
     IQQATNNENL CQCYIGWCPF W
//
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