ID B4HFH7_DROSE Unreviewed; 1903 AA.
AC B4HFH7;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=GM24683 {ECO:0000313|EMBL:EDW41208.1};
GN Name=Dsec\GM24683 {ECO:0000313|EMBL:EDW41208.1};
GN ORFNames=Dsec_GM24683 {ECO:0000313|EMBL:EDW41208.1};
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN [1] {ECO:0000313|EMBL:EDW41208.1, ECO:0000313|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25
RC {ECO:0000313|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the TANC family.
CC {ECO:0000256|ARBA:ARBA00038259}.
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DR EMBL; CH480815; EDW41208.1; -; Genomic_DNA.
DR RefSeq; XP_002030222.1; XM_002030186.1.
DR SMR; B4HFH7; -.
DR STRING; 7238.B4HFH7; -.
DR EnsemblMetazoa; FBtr0207668; FBpp0206160; FBgn0179546.
DR HOGENOM; CLU_001464_1_1_1; -.
DR OMA; SGDHPHQ; -.
DR PhylomeDB; B4HFH7; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005911; C:cell-cell junction; IEA:EnsemblMetazoa.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030018; C:Z disc; IEA:EnsemblMetazoa.
DR GO; GO:0050839; F:cell adhesion molecule binding; IEA:EnsemblMetazoa.
DR GO; GO:0008307; F:structural constituent of muscle; IEA:EnsemblMetazoa.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0061327; P:anterior Malpighian tubule development; IEA:EnsemblMetazoa.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0007520; P:myoblast fusion; IEA:EnsemblMetazoa.
DR GO; GO:0045214; P:sarcomere organization; IEA:EnsemblMetazoa.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR24166; ROLLING PEBBLES, ISOFORM B; 1.
DR PANTHER; PTHR24166:SF55; ROLLING PEBBLES, ISOFORM B; 1.
DR Pfam; PF12796; Ank_2; 3.
DR SMART; SM00248; ANK; 9.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000001292};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 327..364
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REPEAT 1380..1412
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1413..1445
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1524..1556
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1557..1582
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1591..1623
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1624..1656
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1657..1689
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 123..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1824..1851
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 123..140
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1903 AA; 204982 MW; 4A039E0468100D45 CRC64;
MPSLQQIAFA TEGDQSELQT PPLPINPPPK VMANGIVYGF RTRHLSCIEE NDSDSLHGSS
IPHAYDMMQQ ADETFQKLNA NEEQDESGSE DGGLENMDDT IAMIDESRLL EADYLDELVA
EEQLQEQDED EEESSDLVDS GNVEEDFWQP SFNRNDIMMT SVYGALNGSL TSEVTSTATP
GYSECATPRK EAEPVYATPE KRRASNRSFD STCASLTSSL YGGSMNSSLD LKYSSLGGGD
LVSGGISGTS TLRGTSVPPM DLSMMSSDGV SALDWGSASV SCVLDSGDGN PAEELNEEMA
AKCLSAAESD LQSIRRLLEH DASGSVCPSC RISFDKGKRR KLIDTCGHER CYSCMFRNDQ
CPMCMNSSLK DVDGANAQGY DTGIGGSTST IVSPLGSPQP QLRSHAQRNA ALARYMQQHR
QESQSPDYHH RYASNGKLPR AAALSSNGNG FTTGTTQTVT VDVHHQLGGG GGAAAAAKQL
MANGIGSGIS GHSRSSSLSH NIHAAAYSEL SAAPPAFATP PTRRRFFNHK NLRSALTGGS
GGGSGVGGGV GGAGGVGGGH RRTASNGGCP IDTASILSGD HTHQHHHRDN QPEGKETNAL
NTSTCSDSAV TRRRRKNVSN HNLKTSARHG ASSENRLNRL SLAGTSVYAG HLSSLVFGKI
KSLWSVNSSN SSEAGLNQLA GSDTIDHHSS FLNEKLQKDQ LHARLGLLLN DPGSNGNSSS
SGSGCEPISA HSTTSTTSSS GVGAASTTTS GSSQNVSPEQ TLASGAGMLS GSQLSVATSH
GVKEDALSLC GKFKAGCSML HVYEALPSKS RKGNVRRSTR GQQGSSSSAS AASAVGSRVT
ASSLAAVQLA LKPLFFEVPL QEPDPPYVGR QWLVQQLSNI LLGTETRVVL INGQPGTGKT
AFCLQLVEYS CFGRRQMQDD PDGIYSQLQL GAHCERMRGL ASHMVGYHFC QADANLTCQV
PDFVHSLAAQ LCQAPQLTAY RDYLLSEPHL QDILSVRECI ADAERVMKLA ILEPLAHLHR
AGKIPAKVAV IVVDALCEAE YHRPDHGHTI ASFLAQLTPH FPAWLKLVAT VRTQMLELVK
APSYTQLTLD SWASSQALQQ DMLDYIGARL ADSPEIRMNI GGGGGQNSQS GSQPQTKFVS
HLQSLSRGSM LYAKLILDLI ARGQLVIKSS SYKVLPVSLA QIFLLHFNLR FPTARSFEQA
APILNICLAA LYPLTLDEIY YSMEALSHGR EALSWPDFMQ RFKLLDGFLI KRLDNTYMFF
HSSLREWLMR RDEGESNKFL CDARLGHAGI AFRLSRLQAP LSPQLTLELG HHMLKAHLYG
GTSLTLLSPR DLQSYWLAGA ADNISSSLGA LRNVYSPNLK VSRLVLLAGA SPNHRTDYMG
GAPILCIAAH EGILPMVSLL LEFGADVGLT NSQGCTPLIL AAMRGHCDVV RPLVAAGSSL
GQLDITQRCA LVHAARMGHL SVVKYLLACD WSPRPQSQDV TRSVALQQAL IGAAAQAHCK
ILEDLLDLNE TEFDLDVNGM EPSSGELALT AAARHGCVDV VGILISRGAQ IDARNRQGYS
ALWLAVKEGH WSVVEHLLQR GALLDEPLGQ TRKTPLMIAA EEGHLELVDL LLARGAQREA
QDHEGFTALS WACLRGHLAA AKTLIEHGCN RHHEDHNGRT ALDLAAYQGA ASLVLYILEQ
GGNLEHIDVH GMRPLDRAIA CRNIQAVQVF LRKGAKLGPT TWSMAMGKPE ILVILLNKLL
EDGNVLYRKN RFQEAAHRYQ YALRKISGLE QLLERNAIFA QLRTNLLLNL SRCKRKLNEL
DASIDLATQA IAQKPHSYEG YYARAKARME LGALNEALVD ANEAMQQAAQ SGVLCEVVEV
LKRIQTELLT RISISSEDQT GRMSNIGGGA SVTYESHHEI TDL
//
