ID B4HLE4_DROSE Unreviewed; 2018 AA.
AC B4HLE4;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=GM24282 {ECO:0000313|EMBL:EDW41964.1};
GN Name=Dsec\GM24282 {ECO:0000313|EMBL:EDW41964.1};
GN ORFNames=Dsec_GM24282 {ECO:0000313|EMBL:EDW41964.1};
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN [1] {ECO:0000313|EMBL:EDW41964.1, ECO:0000313|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25
RC {ECO:0000313|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR EMBL; CH480815; EDW41964.1; -; Genomic_DNA.
DR RefSeq; XP_002030978.1; XM_002030942.1.
DR STRING; 7238.B4HLE4; -.
DR EnsemblMetazoa; FBtr0207267; FBpp0205759; FBgn0179146.
DR HOGENOM; CLU_000539_2_1_1; -.
DR OMA; NWKERKE; -.
DR PhylomeDB; B4HLE4; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0099080; C:supramolecular complex; IEA:UniProt.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 3.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000001292};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..227
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 268..507
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 440..478
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 578..811
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 849..1084
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1176..1388
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 503..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1915..1936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1915..1933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2018 AA; 223259 MW; 60FBF437F6A64DE8 CRC64;
MAEDTEYKKL PVEERCVHKL WKARVDGYEE AAKIFRELDD EKSPEWSKFA GLIKKMVVDS
NALAQEKGLE AALIFVENSG LAGRTVGDVM TGIVQKCIAA PKTKTKELSV QVALMYVEIE
KQEAVVEELV KGMEAKNPKI VSACVAATTL ALREFGHKVI GVKPLIKKLA PLMSDRDKAV
RDEGKQLAVE IYRWIGAAMK AQISTLPQVT LKELEDEFDK LKGERVEPSR YLKSQQEKQA
KIADAAATED AYNEDDGEAG VEEIDPMDLL DPVDILSKMP KDFYDKLEEK KWTLRKESLE
ILEKLLTDHP KLENGEYGAL VSALKKVITK DSNVVLVAMA GKCLALLAKG LSKRFSNYAS
ACVPSLLEKF KEKKPNVVTA LREAIDAIYG STSLEAQQES IVESLANKNP SVKSETALFM
ARALTRTQPT ALNKKLLKLL TTSLVKTLNE PDPTVRDSSA EALGTLMKLM GDKAVTPLLA
DVDPLKMAKI KECHDKAEIK IKVAGPKKEA RPASAPTAKA GAPAKTTAGS VDPKPVTRPA
TTGARKVLKK PATVSGGATS APTAALKAGG KPLATERELT PEELQEKSEE ILPADILNGL
VDSNWKNRLA AVEQLLGEIT GFDVKQAGIS QILIRTISGR KPGLKEMNFQ VLKFKLDIIR
CVAENYPLTT TTVDLVINEI IEKLADAKNG AGAADVLSAF AEATKLEYVV GKVLSFAFEQ
KSPKVQSEAF NWVSKSIIEF GFQLQPKTLI DDVRKGVQST NPTVRASAIQ LVGTMSMYMG
KTLMMFFDSE KPALKSQIQV EFDKNVGEKP PKPIRGVQRS SGGTAGNSPD NEDDDGGAAG
EEEPINMADL LPRVDISPQI TEALLKEMSD KDWKTRNEGL TKLQAIISEA RLIKPSIGDL
APALAHRLVD SNAKIAQTTL AICEQLATSM GAGCRNHVRN LFPGFLHALG DNKSFVRAAA
LNCINSFGEK GGYKEFFESE MIADALKGGS PALKTELWAW LADKLPGLPP KSVSKEDIHS
MVPHLYAHIC DRNADVRKNA NEAVLGIMIH LGFDAMNRAL DKQKPASKKD ILAALEKARP
NLPVKPLPKG KHQAPIPEEP KPKTVRGGGA GVAPGIQKSA SARVAGGQDK PALARKKDED
IDTSPLLCAN SAKNQRLLDE QKMKVLKWTF VTPREEFTEL LRDQMMTANV NKALIANMFH
DDFRYHLKVI EQLSEDLAGN SRALVCNLDL ILKWLTLRFY DTNPSVLIKG LEYLVQVFQI
GDPKDAVRNG VRRVLRQVIL VFPFVKVFGY VMEGLKSKNA RQRTECLDEL TFLIESYGMN
ICPQSAVREI ARQISDRDNS VRNAALNCIV QVFFLSGEKT YKMIGHLNEK DLSMLDERIK
RAKKTKKPTP PPSVDVQAPQ RHDSIEIEDA EVGNGCDELP PPDEDGTFDQ APSSQLLLLQ
QQLQQLQQQA QQQKPSGPFG LDSQVISEIE RDWVRVDQME QKPLLNVDIS SLDEPIKVRP
TRAGIHYPQE KFDRLISRQH YMQQTLTTSP SSTAGMTSGV SPYRSPMRLQ HQQPQQQLEN
NIPNLADVLP KHDPQLVKVI KGVSSTDTLK ARAAINELAA IIEAPEKQAV LRDYEEIFIQ
NVLAQFKNLS QIPSAQSVVV YQPLLSILYT FFHANILGKT LSVACIKNLM SALLNLMADP
KLAVGDDSQY NKVINGICLK VLDKVDFTNL NCALIRLLRE TCPEAKLPKF TDLLMKCIWR
NVKMLPERSN ELNYDAVILE VHEFMLALPS TWWQNRPSDT PMRTIKTILH NMAKVKGNAI
LQHLNQIPTH SELHTYLIRI LKNFQKDGSA SGIGASPQRA KEIASKRISH QTHDTVSQIF
KLISDRDTKQ QGLQKLYDFK QQNPDIDLST FLQGSSAPFH KYIEEGLAEI ERNQNAGSTQ
APDNRTDVNY QNSGPDPDFW MDRLQYHMTG GAAKLASARS ADDGSHMLDN KVVDENLCLN
GMNAQKASLI KREKRDMSPN RLQHLQAKLA QIKKENHA
//
