ID B4I9G8_DROSE Unreviewed; 1002 AA.
AC B4I9G8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Vacuolar protein sorting-associated protein 18 homolog {ECO:0000256|ARBA:ARBA00017338};
GN Name=Dsec\GM19158 {ECO:0000313|EMBL:EDW43849.1};
GN ORFNames=Dsec_GM19158 {ECO:0000313|EMBL:EDW43849.1};
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN [1] {ECO:0000313|EMBL:EDW43849.1, ECO:0000313|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25
RC {ECO:0000313|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the VPS18 family.
CC {ECO:0000256|ARBA:ARBA00010454}.
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DR EMBL; CH480825; EDW43849.1; -; Genomic_DNA.
DR RefSeq; XP_002040378.1; XM_002040342.1.
DR AlphaFoldDB; B4I9G8; -.
DR STRING; 7238.B4I9G8; -.
DR EnsemblMetazoa; FBtr0202143; FBpp0200635; FBgn0174060.
DR GeneID; 6616012; -.
DR KEGG; dse:6616012; -.
DR HOGENOM; CLU_003488_1_0_1; -.
DR OMA; WIQREKW; -.
DR OrthoDB; 22879at2759; -.
DR PhylomeDB; B4I9G8; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0033263; C:CORVET complex; IEA:EnsemblMetazoa.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030897; C:HOPS complex; IEA:EnsemblMetazoa.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:EnsemblMetazoa.
DR GO; GO:0031594; C:neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019905; F:syntaxin binding; IEA:EnsemblMetazoa.
DR GO; GO:0097352; P:autophagosome maturation; IEA:EnsemblMetazoa.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0051301; P:cell division; IEA:EnsemblMetazoa.
DR GO; GO:0009267; P:cellular response to starvation; IEA:EnsemblMetazoa.
DR GO; GO:0048072; P:compound eye pigmentation; IEA:EnsemblMetazoa.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:EnsemblMetazoa.
DR GO; GO:0032456; P:endocytic recycling; IEA:EnsemblMetazoa.
DR GO; GO:0006897; P:endocytosis; IEA:EnsemblMetazoa.
DR GO; GO:0034058; P:endosomal vesicle fusion; IEA:EnsemblMetazoa.
DR GO; GO:0007032; P:endosome organization; IEA:EnsemblMetazoa.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:EnsemblMetazoa.
DR GO; GO:0008057; P:eye pigment granule organization; IEA:EnsemblMetazoa.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0007220; P:Notch receptor processing; IEA:EnsemblMetazoa.
DR GO; GO:0006727; P:ommochrome biosynthetic process; IEA:EnsemblMetazoa.
DR GO; GO:0061357; P:positive regulation of Wnt protein secretion; IEA:EnsemblMetazoa.
DR GO; GO:0006622; P:protein targeting to lysosome; IEA:EnsemblMetazoa.
DR GO; GO:0006728; P:pteridine biosynthetic process; IEA:EnsemblMetazoa.
DR GO; GO:0098693; P:regulation of synaptic vesicle cycle; IEA:EnsemblMetazoa.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR007810; Pep3_Vps18.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF05131; Pep3_Vps18; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001292};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 44..463
FT /note="Pep3/Vps18/deep orange beta-propeller"
FT /evidence="ECO:0000259|Pfam:PF05131"
FT COILED 834..875
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1002 AA; 115246 MW; 373ECF6CCE3E77DC CRC64;
MDTSINPQPK FLPRIEHNSS GAAANSYVAT SSGNPFETDE EDEIFSRHKM VLRLPSNCTG
DLMHLAVSRN WLVCLLGTPE RTTLLRFFLP RAIPPGEAVL EKYLSGSGYK ITRMFLDPTG
HHIIIALVPK SATAGVSPDF LYIHCLESPQ AQQLKVRRIE KFKDHEITAV AFNPYHGNES
STGPILLGTS RGLIFETELN PAADGHVQRK QLYDLGLGRP KYPITGLKLL RVPNSSRYII
VVTSPECIYT FQETLKAEER SLQAIFAGYV SGVQEPHCEE RKTDLTFSQL RFFAPPNSKY
PKQWAWLCGD GIRVGELSIE ANSAATLIGS TLINLDFEKT MHLSYGERRL NIPKAFVLTE
YHAVLLYADH VRAICLLNQE QVYQEPFDEA RVGKPLSIER DELTGSIYVY TVKTVFNLRV
TREERNVWRI FLDKGQYELA TAHAAGDPEH LQLVLCQRAD AAFADGSYQV AADYYAETDK
TFEEVCLKFM VLPDKRPIIN YVKKRLSRVT TKPMETDELD EDKMNIIKAL VIWLIDLYLI
QINMPDKDEE WRSSWQTEYD EFMMEAHVLS CTRQNRETVR QLIAEHADPR NMAQFAIVIG
DYDEVVAQQL KAECYAEALQ TLINQRNPEL FYKYAPELIT RLPKPTVDAL MAQGSRLEVE
KLVPTLIIME NREQREQTQR YLEFAIYKLN TTNDAIHNFL LHLYAEHEPK LLMKYLEIQG
RDESLVHYDI YYAHKVCTDL DVKEARVFLE CMLHKWISAV DLALTFDMKL AKETASRPSD
SKIRRKLWLR IAYHDIKGTN DVKKALNLLK ECDLLRIEDL LPFFADFEKI DNFKEAICDA
LRDYNQRIQE LQREMAETTE QTDRVTAELQ QLRQHSLTVN SLDTCEICEM MLLVKPFFMF
ICGHKFHSDC LEKHVVPLLT KEQCRRLGTL KQQLEAEVQT QAQPQPGALS KQQAMELQRK
RAALKTEIED ILAADCLFCG LLISTIDQPF VDDWEQVNVE WE
//
