ID B4IXP1_DROGR Unreviewed; 1764 AA.
AC B4IXP1;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=GH14664 {ECO:0000313|EMBL:EDV97503.1};
GN Name=Dgri\GH14664 {ECO:0000313|EMBL:EDV97503.1};
GN ORFNames=Dgri_GH14664 {ECO:0000313|EMBL:EDV97503.1};
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDV97503.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH916366; EDV97503.1; -; Genomic_DNA.
DR RefSeq; XP_001985155.1; XM_001985119.1.
DR STRING; 7222.B4IXP1; -.
DR MEROPS; C19.A48; -.
DR EnsemblMetazoa; FBtr0150078; FBpp0148570; FBgn0122140.
DR GeneID; 6558548; -.
DR KEGG; dgr:6558548; -.
DR eggNOG; KOG1870; Eukaryota.
DR HOGENOM; CLU_001060_10_1_1; -.
DR InParanoid; B4IXP1; -.
DR OrthoDB; 5474185at2759; -.
DR PhylomeDB; B4IXP1; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00443; UCH; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000001070}.
FT DOMAIN 223..258
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 259..294
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 376..546
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 737..1725
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 470..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1581..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1226
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1764 AA; 197656 MW; 978D28A8927826EE CRC64;
MGTKESKHAC ISYEEAVKRV SDAELRRLKD AFKKSAGVGR INLSRNAFQQ DVLCEGVPPK
ITDMLYVACG GTQRGISFKD LLCGLVLITR GTQEEKTKFL WNLYSTDTGY IIKSDYVRNV
SLAPFESVSL FAQGDRVNFE QFQDWIVQHR NATVLSRWLL ADNCVSLTSE LETPTFYQSL
AGVTHLEEKD IGDLEKEFWR LKNTSQNGQI DLQFLGPLIS PPIPKNALAG LFNAFDENRD
GHIDFKELCC GVSAACRGPG VERTRFCFKI FDVDRDGVLS HEETLQMINV LLFVAKENRD
AQQYKDLTKQ HVISDLLEFA QRKSPDGVPS TLTRDNVSLT AEDFMLWNVQ CGLRLMQPLL
DLIFELCHIV FGLWPQCKHM EFDIVRGWLQ REERRPHRVG QFWYLISRDW WLNWMQYTQH
TAHTCDYCKR TASQRSAVDE ALVCDESFNT HSLEQHDSYS LGSVSGSSGI SAGRHCGQQR
PSPIDNSNLI TPNPYRNVRT LTGEGGHLKR DTPLVQNHDF ELVPKSLWKA LNRWYGDNLP
LPRQVIQPPN SEVELELYPL NLRILLHQLQ TASTGSGAAS TQITSWGSTV SAGYGVLASG
GGYAAIAASS VLQAPKRYLA YTAAFSRLAT VRQVGEFLCD QLRLKPEDIR LWHVPPSSAT
LDNSAILLEE DTMCLKELLI RDNDQLLLEI RNKDLTWPEE LSSLASTQSG QAGVACPGDR
RRMTRTSIMS VHAPGATGLH NLGNTCFMNA ALQVLFNTQP LAQYFHRQMH RFELNAANKL
GTRGQLAMRY SELLKEVWTA TTRSVAPLKL RFCVNKHAPQ FSGGGQHDSQ ELLEWLLDAL
HEDLNRVMEK PYSELKDSNG RPDKIVAAEA WSQHHARNQS IIIDLFYGQL KSKVSCLSCG
HESVRFDPFS LLSLPLPVEN YVYLEVLVIL LDGSVPIKYG LRLNSECKYA DLKHKLATLC
PLQPSLMLVC ELWNSQIRQV LADEDKLRTQ SAKELYVYQL PEQTSARTRS NSALSMHIEQ
GLKDIQRSSA LITTQDSLSS LSTLPTSNQT TASRVICNGH VVTDGQELAI DADHEISKYS
SNNNSNSNRN NNSSSQVHEL QPDDAGKESL ILSCSPENSF MHDPVTQQKR VSSTKLLHTE
SNTSSYTNHS GENSMESSLT EPMPVAELAA SRHGSNSDDG ASNEHSSGMS TAHTLGINSF
DRDVDDDDDD ADADADGDEQ GDGEEEPDQQ ITTSQPESSS GNQTSSGVYS RRSSQPYKVG
KYLVAVHRKI TRHDSYFLSY HKTRPSLFGV PLLIPNCDGG THKDLYCAVW LQVSRVLSPL
PATTEQANHA ADCDDSLGYD FPFTLRAVKA DGLTCAICPW SSFCRGCEIR CNNDYVLQGA
LPPINSVAGS NTTTPFTNVK CPSLPNLEAK RSPEYTTSLS YTPTTKYFED FTIAIDWDPT
ALHLRYQSTL ERLWVDHETI AICRREQVEP VDLNHCLRAF TSEEKLEQWY HCSHCKGKKP
ATKKLQIWKL PPILIVHLKR FNCVNGKWVK SQKVVHFPFD DFDPTPYLAS VPQETILRHK
ELLEMKRDFI SASNEVVSEL DEVDASDKTT AEAAPPPKAV DSEKVPPAKE SPLVASSMLR
QTKSSNAARR QRLISTSLTK TPIVDGEFED YHQHKLKAGV DEFDPRYKLY AVVSHSGMLN
GGHYISYAAN TTGSWYCYND SSCREISQKP NIDPSAAYLL FYERQGLDYE PYLPNIEGRA
LPNATQQLDV DETEGELKKL CTIS
//
