ID B4J1Z0_DROGR Unreviewed; 1373 AA.
AC B4J1Z0;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=GH15508 {ECO:0000313|EMBL:EDV95915.1};
GN Name=Dgri\GH15508 {ECO:0000313|EMBL:EDV95915.1};
GN ORFNames=Dgri_GH15508 {ECO:0000313|EMBL:EDV95915.1};
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDV95915.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the unc-13 family.
CC {ECO:0000256|ARBA:ARBA00005823}.
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DR EMBL; CH916366; EDV95915.1; -; Genomic_DNA.
DR RefSeq; XP_001983567.1; XM_001983531.1.
DR SMR; B4J1Z0; -.
DR STRING; 7222.B4J1Z0; -.
DR EnsemblMetazoa; FBtr0150922; FBpp0149414; FBgn0122980.
DR GeneID; 6556724; -.
DR KEGG; dgr:6556724; -.
DR eggNOG; KOG1328; Eukaryota.
DR HOGENOM; CLU_003295_2_0_1; -.
DR InParanoid; B4J1Z0; -.
DR OMA; WLAEAMN; -.
DR OrthoDB; 3059697at2759; -.
DR PhylomeDB; B4J1Z0; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR CDD; cd08676; C2A_Munc13-like; 1.
DR CDD; cd04009; C2B_Munc13-like; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR PANTHER; PTHR45999; UNC-13-4A, ISOFORM B; 1.
DR PANTHER; PTHR45999:SF4; UNC-13-4A, ISOFORM B; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000001070}.
FT DOMAIN 332..526
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 854..978
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1075..1185
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1197..1324
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 27..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1373 AA; 154043 MW; 007E88D61023194A CRC64;
MSFLSSMQQY VTSGISSLGL GNRRFSLSRQ ESTEHQQQQQ QQAGGGGGGG VIAAAGITIQ
QQLLPQQQQQ QQLLQQQQQQ QLQQQQQHSH APLQQQASIG SGLGIVYGAP AQPTAGVAAT
VAGSNYPAGG VVIGNPNATN PLLGYPKVVP LPGSSGAGGA AGVGNCSSAG STPMNSRRQS
RALECLAPPR TGSFRSRNSP LHQPDPPPRP PLAFCKRRLS WPEVDPRSTS GVQETDGSYF
ENFTSLGWKR ENRRMSATRA AESRAEANPE NERDPPAPEE SIDRHDEKEK LYVEVLHTIA
NTVGAPAPGG QFAHYKDEMY LHAQRAFGVN PDRHYRLLHA SAEDKPKIIV LSAVVIEADG
LEAKDANGFS DPYCMLGIQP DGGPPVSPLP LPPTPRALSA DMSGGFDNSA TDSPPHRKHS
FRLSFKRREG AVRREQRDSL GGPVPAKLIK ATSIKPHTLS PKWNEKFKFD IDDINTDTFH
LDIWDHDDES CVMDAVSRLN EVRGVRGLGR FFKQVCQSAR QGSQDDFLGA INIPIAEIPS
TGLDAWFKLE ARSHRSTVQG RIRLKLWLST REDRGLVPDE NNEQQLRKIE QLQLVFMQHE
VTTHEPSWTW CGDLPGPALT ILHQLAVQGE LTDLQCAMAR YVAAARLNRT TPLDPKFLHR
LLSDVEKQWN QPNQEALTRD LEQWLAEAMN GFVERSLNQI RRHRDIFPAL NPPSLIRLEF
LLRCLGLLGS MRAFRAVCPF NKGVRGEVVN ALRKGSVMWG QNVLRESQSL ANPLSNFVTT
LTADIQLGQT YYHALFDNTN GIQYFSIIYK QYDAMVGDEV YTRMAAGQVP GVRMNLSQYA
VLEGDAEPVD AKPFELFLAL QEFCQLKRHL SAQPQPPEKP LALSNSHEWF IPTFERWMMV
SKAKALQRIR AAIRMDAICE GERIVRYSSS SVDTASTLLN IKEFWKVINW PDEDTAIMME
SQLIDVVCSA AMHYCDLIHT TLADSGYYEQ QGPFRCSDDM CVTVNNVEYV RRTLAEFRSD
EQPLEESADN LLESSLTHME NRCERILSKL APLMQMSLQK AVFHLAWSPD SLPANQAIVP
LLEYLDCHLA ALNSALLTKN FNRSLRFIWK TVLGEMARQM ETGDETDKPT HFHKRLYEAL
QLLVDFFHAE GQGLLIECLH TEDFWRIEQR LQFHKTDTDR LIDMFYMNRL REQLMAVSPG
PYGSLAVRSY FNHDSLCVEI LHARDVVPLD PNGFSDPFVV IELLPRRIFL HCMEQQTNVH
KRTLNPIFDE CFEFSVTLEQ CLVDGAMICF TVMDHDVLTA NDFGGEAYLA LGNIPGVADY
STSVDNFHGL KQIELPLMQQ KDKCNPILQI LELRINDKQA QDFVRKQKAR FIN
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