GenomeNet

Database: UniProt
Entry: B4J8W8_DROGR
LinkDB: B4J8W8_DROGR
Original site: B4J8W8_DROGR 
ID   B4J8W8_DROGR            Unreviewed;      2487 AA.
AC   B4J8W8;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-SEP-2017, entry version 62.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dgri\GH19909 {ECO:0000313|EMBL:EDW02408.1};
GN   ORFNames=Dgri_GH19909 {ECO:0000313|EMBL:EDW02408.1}, GH19909
GN   {ECO:0000313|FlyBase:FBgn0127373};
OS   Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN   [1] {ECO:0000313|EMBL:EDW02408.1, ECO:0000313|Proteomes:UP000001070}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH916367; EDW02408.1; -; Genomic_DNA.
DR   RefSeq; XP_001987541.1; XM_001987505.1.
DR   STRING; 7222.FBpp0153815; -.
DR   EnsemblMetazoa; FBtr0155323; FBpp0153815; FBgn0127373.
DR   GeneID; 6560404; -.
DR   KEGG; dgr:Dgri_GH19909; -.
DR   FlyBase; FBgn0127373; Dgri\GH19909.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; B4J8W8; -.
DR   KO; K21862; -.
DR   OMA; QIWVNDT; -.
DR   OrthoDB; EOG091G01WJ; -.
DR   PhylomeDB; B4J8W8; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028820; Na_channel_60E.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF257; PTHR10037:SF257; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001070};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001070};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    126    144       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    151    169       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    189    209       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    244    264       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    372    398       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    694    712       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    758    782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    802    833       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    891    916       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1784   1804       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1813   1835       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1841   1863       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1895   1921       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2013   2037       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2099   2119       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2125   2146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2158   2176       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2215   2243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2315   2338       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      124    403       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      693    923       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1780   2046       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2098   2348       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2354   2415       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   2487 AA;  283527 MW;  3882881B1252CA5E CRC64;
     MNQQLILTLY WTFAKHQVVA YTQKSQVKHE NRHIQLVREY GFHPRTKASV EDGDVLPRKF
     EPFPEDMYGK PLEEIDTFIY EETFCVVSKR FRKNYIHRFT GTQSLFLFHP WSPWRRVCVY
     IATNQFFDYC VMATILFNCI FLAMTETVEE AEYIFLAIYS IEMVIKIIAK GFLLNKYTYL
     RNPWNWLDFV VITSGYATIG MEVGNLAGLR TFRVLRALKT VSIMPGLKTI INALLHSFRQ
     LAEVMTLTIF CLMVFALFAL QVYMGELRNK CVRNVPADWT NISHLDWQIW VNDTDNWLYD
     EDEMPMLCGN LTGARHCPFG FVCICVGENP NHGYTNFDNF MWSMLTTFQL ITLDYWENVY
     NMVLATCGPM SVSFFTVVVF FGSFYLINLM LAVVALSYEE EAEITNEERK KDLLDHRDDS
     TFSFDPSVLN VKMLNKNNKK KIDSRKGVLL ASYSKKKTRR KKTKGGKDNT STNGSNGNDH
     DNAKSPSGTP SPNPSPRHSN TDRPSALALQ AQKQMEQQQQ QKQLIKSETA AAAEAATSEQ
     QQQEQQQKTR ISFKEGNVKN PNMLYPSDYK GQLITSSRQT SSNSSGGVNR ESSQDDSGVV
     DDHEEQDTGN EMGHVSTVEL ALSPREVRLI KCNGNIARIK NHNVYALHQE FSSEVVVIDD
     LPDRNCDRCV HCCADYESWL QFQNCLYKVV RDPLFELAIT LCIVLNTAFL AMEHHGMSES
     FRNALDVGNK VFTSIFTFEC IVKLMALSKD FFLCGWNIFD LIIVTASLLD IIFELVDGLS
     VLRGLRLLRV LKLAQSWTTM KVLLSIIIST IGALGNLTLI LVIVIYIFAV IGMQLFSKDY
     TPEKFDPDPV PRWNFNDFFH SFMMIFRILC GEWIEPLWDC MRAEEEQGAS TCFAIFLPTL
     VMGNFMVLNL FLALLLNSFN SEELKSKKEE VGEESKLARS IERVRDLIRK KRQERKDRKE
     RKYAEKFQQI VLEAQQAHAT SVAARELDKP NLLAETKFHR LSYQESMNRP VSGSDFGFQI
     PLSDGLHTIV DGLEYDESSE PASEQQQQQQ MQQQQPSSDC LPPTYECAML TASSIENNGC
     ENNLSPLGPT ERSSRLQHQI SSGVGTQQND SRDEATYTES IELRLLGQYN STDTDPYAYA
     PDQRSGSFAR GDSLQDTDEA YLKYQKSLLT RSPSYRKSLD RLSQSSGQSQ RSLLPSRSLK
     SEESAMRRHS SGLSLNSISL EQDELLSQQA NLREELLNCD QKELFQFLQE DEELLGMARR
     EKKPTTSSIK SNLSYISNSI MQTLDSRHSG SHSSHGIGQQ ESEPLMEHSE FDNIIQSFEK
     ELEEIKRSTS SLERKISTLS EPSPAADEAT KAIMDHIAII TGASERTTAD EVVHPLNPYD
     SYDLSSVPRR SQSVSAAAQR QSVKLKRRSL EKQRKIDEDF SISNEIRKIC DQIHAPFAAM
     EALAVAATTS ATGGNQSPFM RRKHDPFSVQ FDRFKRLSLI ERVEELPEED KPISTLRIES
     EKMPRKFLNN DKLRMDSLSL KSTNSYENLL IQKQLCRDAG HHPMVMGVPA TPPTSLKSSI
     EPPTLAQISS LKATPPLAAL TEHQQHYHAT SIQTTQQTMH PTAVGAASAK RRAEHPQSTL
     DKAASFQSAR TESHSSGVAD NSSVLALGHA GNRSLSNGHH DRASDKTDPT ANATATATNA
     TTKPSAFSRL TEKPWHCLVS YVDDLTVGGR RNSQGAYNDP MTFPSYGEAK PPKVPDDCFP
     QKCYEHFYFR CPWFMSCMDT PSAKHWTRVR TAVLAVVDTP AFEWFVLVLI FASSITLCFE
     DIYLDSNKTL KRVLYWTNFS FCLIFVVEMV LKWLALGFSK YFTSFWTILD FIIVFVSVFS
     LLIEENENLK VLRSLRTLRA LRPLRAISRW QGMRIVVNAL MYAIPSIFNV LLVCLVFWLI
     FSIMGVQFFG GKFFKCINEL GELLPITEVN DKWDCIEQNY TWINSKITFD HVGMGYLALL
     QVATFEGWME VMADAVDARG VDLQPQREAN LYAYIYFVIF IVCGSFFTLN LFIGVIIDNF
     NMLKKKYEGG VLEMFLTESQ KHYYTAMKKL GRKKPQKVIK RPINHFLAMF YDLSNSRRFE
     IAIFVLIFLN MLTMGIEHYD QPHAVFFILE VSNAFFTTVF GLEAIVKIVG LRYHYFTVPW
     NVFDFLLVLA SIFGILMEDI MIDLPISPTL LRVVRVFRIG RILRLIKAAK GIRKLLFALV
     VSLPALFNIG ALLGLITFIY AILGMSLFGH VKLQGALDDM VNFQTFGRSM QLLFRLMTSA
     GWNDVLESLM IQPPDCDPFF NRQANGDCGH PLLAITYFTS FIIISYMIVI NMYIAIILEN
     FNQAHQEEEI GIVEDDLEMF YIRWSKYDPH ATQFIHFSQL SDFIASLDPP LGISKPNNVA
     LVSFNLPISK GNKIHCLDIL HALVKHVLGH VEETDNFKQL QEQMDVKFKK QFPTRKELEI
     VSSTRIWKRQ EKAAKTIQTG WKDYLRY
//
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