ID B4JBJ4_DROGR Unreviewed; 2153 AA.
AC B4JBJ4;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=GH11564 {ECO:0000313|EMBL:EDW04017.1};
GN Name=Dgri\GH11564 {ECO:0000313|EMBL:EDW04017.1};
GN ORFNames=Dgri_GH11564 {ECO:0000313|EMBL:EDW04017.1};
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDW04017.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; CH916368; EDW04017.1; -; Genomic_DNA.
DR RefSeq; XP_001989150.1; XM_001989114.1.
DR SMR; B4JBJ4; -.
DR STRING; 7222.B4JBJ4; -.
DR eggNOG; KOG0161; Eukaryota.
DR HOGENOM; CLU_000192_8_0_1; -.
DR InParanoid; B4JBJ4; -.
DR OMA; DQLADNE; -.
DR PhylomeDB; B4JBJ4; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0030017; C:sarcomere; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14909; MYSc_Myh1_insects_crustaceans; 1.
DR Gene3D; 1.20.5.340; -; 4.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.58.530; -; 3.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 3.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615:SF40; MYOSIN HEAVY CHAIN, MUSCLE-RELATED; 1.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF00063; Myosin_head; 3.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000001070};
KW Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 134..968
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 818..840
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 2013..2053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2113..2153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 227..234
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2153 AA; 247360 MW; 5C9560B5A8A837FD CRC64;
MPKPAASQED EDPTPYLFVS LEQRRIDQSK PYDSKKNCWV PDEKEGFLIG DIKATKGDIV
SVGLPGGEVK DFKADKVEKV NPPKFEKLED MADMTVLNTP CVLHNLRQRY YAKLIYTKDF
KKDLLSQVNP PKYEKAEDMS NLTYLNDASV LHNLRQRYYN KLIYTYSGLF CVAINPYKRY
PVYTNRCAKM YRGKRRNEVP PHIFAISDGA YVDMLTNHVN QSMLITGESG AGKTENTKKV
IAYFATVGAS TKKDESQKNK GSLEDQVVQT NPVLEAFGNA KTVRNDNSSR FGKFIRIHFG
PTGKLAGADI ETYLLEKARV ISQQSLERSY HIFYQIMSGA VAGVKEICGL SDNIYDYHIV
SQGKVTVPSI DDNEEMNLTD QAFDILGFTK EEKENVYRIT AAVMHMGGMK FKQRGREEQA
EQDGEEEGGR VSKLFGCDTA ELYKNLLKPR IKVGNEFVTQ GRNVQQVTNS IGALCKGVFD
RLFKWLVKKC NETLDTKQKR QHFIGVLDIA GFEIFDYNGF EQLCINFTNE KLQQFFNHVM
FVLEQEEYTK EGIHWDFIDF GMDLLACIEL IEKYNGFEQL CINFTNEKLQ QFFNHHMFVL
EQEEYKKEGI EWAFIDFGMD LLACIDLIEK YNGFEQLCIN FTNEKLQQFF NHHMFVLEQE
EYQREGIEWT FIDFGMDLQT CIDLIEKPMG ILSILEEESM FPKATDQTFS EKLTNTHLGK
SAPFQKPKPP KPGQQAAHFA IGHYAGVVAY NITGWLEKNK DPLNDTVVDQ FKKSQNKLLI
EIFADHPGQS GTAEQAKGGR GKKGGGFATV SSAYKEQLNS LMAILRSTQP HFVRCIIPNE
MKQPGMVDAH LVMHQLTCNG VLEGIRICRK GFPNRMIYPD FKMRYQILNP RGIKDLSDPK
KASKVLIETT ELNDDLYRLG HTKGMEDPKK CTKVLIESTE LTDDQFRMGN TKVFFRAGVL
GQMEEFRDER LGKIMSWMQA WARGYLSRRG FKKLQEQRVA LKVVQRNLRK YLQLRTWPWY
KLWQKIKPLL NVSRIEDEIA RLEEKAKKAE ELHAAEVKVR KELEVLNAKL LAEKTALLDS
LSGEKGQLQD FQERNAKLTA QKNDCENQLR DIQERLTQEE DARNQLFQQK KKADQEISGL
KKDIEDMELN IQKAEQDKAT KDHQIRNLND EIAHQDELIN KLNKEKKMQG ESNQKTGEEL
QAAEDKINHL NKVKAKLEQT LDELEDSLER EKKVRGDVEK GKRKVEGDLK LTQEAVADLE
RNKKELEQTI QRKDKELSSI TAKLEDEQVV VGKHQRQIKE LQARIEELEE EVEAERQARA
KAEKQRADLA RELEELGERL EEAGGATSAQ IELNKKREAE LSKLRRDLEE ANIQHESTLA
NLRKKHNDAV AEMAEQVDQL NKLKAKAEHD RQSSHNELNQ TRTACDQLAR DKAAQEKIAK
QLQHTLNEVQ SKLDETNRTL NDFDASKKKL SIENSDLLRQ LEEAESQVSQ LSKIKISLTT
QLEDTKRLAD EESRERATLL GKFRNLEHDL DNLREQVEEE AEGKADLQRQ LSKANAEAQV
WRSKYESDGV ARSEELEEAK RKLQARLAEA EETIESLNQK CIGLEKTKQR LSTEVEDLQL
EVDRANAIAS AAEKKQKAFD KIIGEWKLKV DDLAAELDAS QKECRNYSTE LFRLKGAYEE
GQEQLEAVRR ENKNLADEVK DLLDQIGEGG RNIHEIEKAR KRLEAEKDEL QAALEEAEAA
LEQEENKVLR AQLELSQVRQ EIDRRIQEKE EEFENTRKNH QRALDSMQAS LEAEAKGKAE
ALRMKKKLEA DINELEIALD HANKANAEAQ KNIKRYQQQL KDIQTALEEE QRARDDAREQ
LGISERRANA LQNELEESRT LLEQADRGRR QAEQELADAH EQLNEVSAQN ASISAAKRKL
ESELQTLHSD LDELLNEAKN SEEKAKKAMV DAARLADELR AEQDHAQTQE KLRKALEQQI
KELQVRLDEA EANALKGGKK AIQKLEQRVR ELENELDGEQ RRHADAQKNL RKSERRVKEL
SFQSEEDRKN HERMQDLVDK LQQKIKTYKR QIEEAEEIAA LNLAKFRKAQ QELEEAEERA
DLAEQAISKF RAKGRAGSVG RGGSPAPRAT SVRPQFDGLA FPPRFDLAPE NEF
//
