ID B4JNE8_DROGR Unreviewed; 2464 AA.
AC B4JNE8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=GH24152 {ECO:0000313|EMBL:EDV92241.1};
GN Name=Dgri\GH24152 {ECO:0000313|EMBL:EDV92241.1};
GN ORFNames=Dgri_GH24152 {ECO:0000313|EMBL:EDV92241.1};
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDV92241.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH916371; EDV92241.1; -; Genomic_DNA.
DR RefSeq; XP_001992534.1; XM_001992498.1.
DR STRING; 7222.B4JNE8; -.
DR eggNOG; KOG1512; Eukaryota.
DR HOGENOM; CLU_231633_0_0_1; -.
DR InParanoid; B4JNE8; -.
DR OMA; CGATRPE; -.
DR PhylomeDB; B4JNE8; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15529; PHD2_PHF10; 1.
DR CDD; cd21085; WH_NTD_PHF10; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR20916:SF18; BED-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR20916; CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001070};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 2063..2122
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2119..2167
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1408..1511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1950..2059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2250..2271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2374..2399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 551..578
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1408..1427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1951..1971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2001..2015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2023..2051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2256..2271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2374..2389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2464 AA; 261459 MW; C24B216988D23685 CRC64;
MNDLRQQQVQ VQVAATSSSV SLAAAPLCSN SSSTSSSSSN NSNSSSASVS PRSSSNSNSS
IGSNGKAVIT TTTTATTSNN NSSISSSISS SNQRQQQQQE EEDEEQQIVS SSTSSPAQQQ
QQRQQLNVST TAAATHRHYQ QQHQQQQQHQ QQQHQQQQLL HPVGQITSTT ASPPQHRLRD
DAQLPNSPSS NNNSSSSSSS TAATMVATSI DVNGEEKNNS SNSNSNSSSS SSSNNSSSAV
VGGAKGGSSS SHKLILKLSK HNTASNTSES LTGNDERRVE PLRIQLSTQL PTTTASTTTT
AAAAAVAATA SQMGQQQAAA AAVVPKLTIR PIKSQDVAAA VNSDASSSSC SSSSCADDEQ
LPHIVPKLTI RAANEERVSS VVPKLIIKMP DAGGGGGGGE ANNCISPLKS SMAAGGSGTG
SPALPKLTIK TTKLDGSGGE TQLISCSLSL ASAPSSSASS SSSSSYSSSS GCEQPVAMPP
TVPKLMIKTT QAGSSCISSS SSQEQHQQQQ QQIPKLTIKT GGNQEHQQQQ QQAQHTVIMT
LDTRNAQSIP KLTIKTKSIE LEDELQQQQQ QEQQQQQQQV PKLTIKSSNC SEQQQQQQQP
MLKLTIKNLC SPKHKVRAVL EEKVLTSKLT LTNGGDNSDY PDATAATAAA AATVDSDTDE
LRRNSDDMDI DDALSKEHDP KIFHNLPPAT SSSSSSNSNG IVAQQQQQQH NIVDTVDLTS
SPSPGSSPAH AVNSNYATEA TAAAAATTTA SSVAATATNR SLSAAQSQNL LLECLRNNSS
SNSSNPASPN SNILLSQLTA PPKSFSSSSN NNSSSSSNLT TAAKYPQLTE RLMANGAATA
AAASTTTTTS IVTAATTEPI IDSIEILDTP EGSPHPHPHP HTHSQLMMMP HMQSAYESET
ATTLPPIQQQ QQPPAPLSNH VNHINHNLNL NLNHKLDNQQ QSHQQQQLKT DEIHLKRQQQ
HHHQQHLQTE AESPSGLPPN KQRRTDNNEN DQQTHNCSSN DTAATAAVAA AAAAATTPQQ
QQQPTHRSRK QKHERILNTE LEEPQQQQLH QQQQKHLQLL HVEQALNNGT LLLDDEELVD
SSATAATTTT VAASVAAFAA KQRGVLVAEL GLSVGGSGKR RGRPKRNANE TTTPAATAAG
SAISPATPTT AERHDAKVES AVKSRRVQLL RKRLAIDMVS AEQPDLLIPA AVSAARTNDL
MPSMHQMDAT ELMAALATPA ATSGTPAATT PRRNEQRPMR ATRRSAATPT VATPAKKTSK
RQSKAAAAAA AAAAAAAAVA ATLTAVAAAA KADRDAAVFL YHFDGAANDA ESNNTSSSGS
NNNNNNNNNN SSSNNNNSMA YALAAQIDLT MCSSSSSTSN GADATSASIG STCSMLPPTS
ILSSSDPLPD VIFQPNDFSS IMATQQLRNN NNSNSNNSNT NSISGGSQHD SHDEDNYSTL
LDNSGDESSQ QANNNSILGA FAGSSPTVVP TVPTRGRGRG RGSRGGAGGS SRTGSNNANS
AQPRVPRMSR GASAVAKAIA LSRPRCVGGL KHQPDPDRIK GFFSPDAALS ALWRVHVFTP
GIEEDTRMSA DLNNSNQSVT SMEPPLTPQK QPDFLNNEES QSSMQSSISL MDSNQGQSSV
DAIIGSALKR PKKKKMEICV AEDTDFNAAT IAEYDWPPPK GCCPSKNRDT FMIQEQVALY
LGITSFKRKY PDLPRRAVDM EERNWLQEKG LVSEKMCDLG ITAVWASDIL DIMYTDFHEK
YEEYKEYIRQ KHLRDIEAKQ KALGLTVGNG RGLQARDRAM LSTSKWNGYF NKTRKEERLA
CLDLQTFTMN LPVAREAPSS TLLHRSIANT VRMAALAEDM PAPPFLLAPR TFDAAYQRLD
YAYPLALVPG QFASNYRQLT PAQLRAYPLN TALEKPQKKL TALQLDAAAA AIKEEQLQQP
RPSSKLLSTA LALRRQQRVR QQLDAAAAVV KEEQQQQSQQ QQQQPPSSKL LDTSLALRRH
PRVRQQPMRN SNDPAKMCAG GYSSASSSSD ASSSDSDSDG DSDSDSSCSS SSASRSSSGS
SSSMNSNSEA ELQKREQQDA RLSSNCGVCR RSQHRNARNM PEAYIRCYSC RRRVHPSCIE
MPQRMVGRVR NYNWQCAECK CCIKCRSSQQ PGKMLYCEQC DRGYHIYCLG VKTVPEGRWS
CERCSICMRC GATRPEGLPQ TAALQLQSAS MFLLSPSGGS NGNGNISDKT IVKPPVKHKK
VKWMNEYRID HITQLREHCT MLCVPCARAK PAKRQTPPRT PSSSSCSSSS SNNSSSNAAA
CTQSSPASQA ASVQLQLTSA SSSSSLHYSI NGGDRCTTTT TTTTTAAAAT PALSPKSCSS
SSSGNSSSAN GSGAILMAPP LAAEAANATG GATMPYNNNN SSNSGKRMPV GINKSHPDMA
TMQCSSFNRN SNEDAAAANN YNNSAAATTT IITQATTAAA TTTTTAAAST TATTIGIAPP
PVVA
//
