ID B4KHW3_DROMO Unreviewed; 1907 AA.
AC B4KHW3;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=GTPase-activating protein CdGAPr {ECO:0008006|Google:ProtNLM};
GN Name=Dmoj\GI18189 {ECO:0000313|EMBL:EDW13400.1};
GN ORFNames=Dmoj_GI18189 {ECO:0000313|EMBL:EDW13400.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW13400.1, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:EDW13400.1, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH933807; EDW13400.1; -; Genomic_DNA.
DR RefSeq; XP_002003958.1; XM_002003922.2.
DR SMR; B4KHW3; -.
DR EnsemblMetazoa; FBtr0168914; FBpp0167406; FBgn0140928.
DR GeneID; 6578033; -.
DR KEGG; dmo:Dmoj_GI18189; -.
DR eggNOG; KOG1449; Eukaryota.
DR HOGENOM; CLU_235685_0_0_1; -.
DR InParanoid; B4KHW3; -.
DR OMA; FERGQPM; -.
DR OrthoDB; 2913909at2759; -.
DR PhylomeDB; B4KHW3; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF10; GTPASE-ACTIVATING PROTEIN CDGAPR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 305..373
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 434..628
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 98..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1788..1820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1862..1888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1061
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1793..1820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1868..1888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1907 AA; 211763 MW; DE75DC330441D6EC CRC64;
MSEKVSSTLA AQLHAHSHSH SLALANSSSA SASVELQQQQ SLIGSREAAL PFETEAPAAA
ISAQLNFKIV PVDSMMASGM PLGLGNSQEM FGSMNTSQIS NASTESSCSP PTAAPPKPSR
HMAVQPLNSK SCRFPKLEEC AHFHYERVQL GALSVQLLDD KSEQQLGSSI ASQSIGGELA
HSSMRSAAFT PENCWFIIRV CPQGCEPFLI KRSFENMQML DEMLHRCVYD RKISGLRNMS
ELGADEDLQS ELDVEYAVAK YLERFSKIAS DSLTCGTILT WLQLDNKGRR LPLADGETQR
TINTPAVGAA YGVRRYQAQA PDEINIEVGD MISVIDMPSP AESIWWRGKK SHLQKSLYEV
GFFPQSCVAT IGDKVPRNFP MPAPLVGHLD ASPTKPVLRK HGKLIAFFRS FILSRPSRRR
LKQSGIYRER VFSCDLSEHL LNSGQDIPMV LRSCAEFIEN YGVIDGIYRL SGITSNIQRL
RRAFDEERVP DLGNPEMKQD IHAVSSLLKM YFRELPNPLC TYQLYDNFVE AIQVKADEAD
ERLRLMKETV LKLPPPHYRT LKYLSEHLHK VSQHHERTGM TDKNLAIVWA PNLLRSPALE
SGGVAALRGV GVQAVVTEYL IRNCHNIFDA LEDHNARLSI VGNAAAAAAA AATAAQGELR
MESLTDCESL LVEQREQDQS LGLMERPKSL STGGAKLISL EEAQERHSRI ECGTDLKQSL
PINMIMSNST AAASNIGSYI EVGGGPSSLP DKYHTVLSVP RSWQKRKPDK TPSWKSIFTR
SQRQGNEPGH KLIIDGGASS KDANVSTRVC FVQASHAHAS KELSKHDKPK SIELLETTRD
ARRDSALGII GKPMELCIRS NSIDSLRTVG HSRSVSHDSY FDLLQSPQRG HMTTCPSREL
SELGLNFDRE EPEMRIFSES ESLVSSPRVG KENVPPATGC ATRRIMRARP EEFSSQTNSV
NPSPKKQPRL NLLSPSSART LPQSVAPQQQ QQQQPQQQQQ EGACGHEPAG AENCCKRYKL
EDQLSDIQFI DCGTPEHPQQ QFASVEVHQP PPPPKPARAQ PLPSPTAAST AVRYSYPSVQ
VGAKRKEQLA AKERFSYQGT FTQQGAKPEA TASRPMQNGS KLPVPTPTTP SHSPRYSLLL
CDTESSENSS AVNTPQYDME PLMVNSVMSG ISGVSSNLQQ QQQPLLLGVD AASYLGSSHE
SLGQQQQQFQ PEQRDMHALK RELSLDLQPQ QQPRRGATLP VKDLLQAASS PNNSNFTDNT
SQSVTPSEFG YQHLQRHLSM HSLLATEESS PLYEDFEQTP SNALSPAKHL PAASISSPIK
STISITYKSP EKEKPPTKPA LLLETNFDEN IVYEQVKLFR NSVTEVNQML NERHGQSLKQ
IEEEDGSAQM AQQLLQLQKE QEVDEDEEQR DQEQLLYENI ELRKPKTVYE NLRGEEMKLN
VASDDLLELE TDSDLNLESV AKHQPSCDRI ELDSLDSLPS VEHNMEHEKQ EQLEHSEQLP
PSKSPSFSVK ELATKFESSP VEQLPNFDFS QRGGSMKKPN NELSLPPVAV PPKPLLMPVP
LKKRNANAQK ITRSLDENAF VREFGGKQLQ DLTACNQQQQ QQQQQPQLPM SELDNRRKSF
DFTRPKTLNP PKRLPGMSIT EEICQKRNSE SVDQQITTPT TENRISLIQQ NNVPLNPPAS
NGRKSVLTGV ILDRERIDKI KEERRQQLTQ KYYGDSIKSR SKTELNSADD NNFQASESLR
VKSKSRGDMH SLQKDMDMNL KQLARAGAGS ESTLHQQIDY GTQHRVRSIS DEKNQNCDTN
TNTNTTNTSN SASNTNGGAV NQSNSVKSVA QKYAQNNAPV ITAITASTMP GKFERGIGNR
ERLSRNSMPH PIASTESNAS VNNREKISPQ FSIRDVTAMF ESRSQNQ
//