ID B4KMC6_DROMO Unreviewed; 1460 AA.
AC B4KMC6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Histone-lysine N-methyltransferase 2C {ECO:0008006|Google:ProtNLM};
GN Name=Dmoj\GI18846 {ECO:0000313|EMBL:EDW09814.2};
GN ORFNames=Dmoj_GI18846 {ECO:0000313|EMBL:EDW09814.2};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW09814.2, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:EDW09814.2, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CH933808; EDW09814.2; -; Genomic_DNA.
DR RefSeq; XP_002005879.2; XM_002005843.2.
DR SMR; B4KMC6; -.
DR EnsemblMetazoa; FBtr0423291; FBpp0381247; FBgn0141585.
DR GeneID; 6580006; -.
DR KEGG; dmo:Dmoj_GI18846; -.
DR eggNOG; KOG1245; Eukaryota.
DR eggNOG; KOG4443; Eukaryota.
DR HOGENOM; CLU_001919_0_0_1; -.
DR InParanoid; B4KMC6; -.
DR OrthoDB; 2912893at2759; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd21997; HMG_KMT2C-like; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15510; PHD2_KMT2C_like; 1.
DR CDD; cd15512; PHD4_KMT2C_like; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15514; PHD6_KMT2C_like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 6.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF00628; PHD; 2.
DR SMART; SM00249; PHD; 7.
DR SMART; SM00184; RING; 4.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50016; ZF_PHD_2; 6.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 209..259
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 256..307
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 340..401
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 343..399
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 531..584
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 581..631
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 658..713
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 794..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1196..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1460 AA; 163400 MW; B182B7633318215E CRC64;
MSVNMLGNID EKNVVVPNVD ELPYFPEKFP GKVCCLCNLG ERSGLGQGTM LQLKVPADLK
ERKPNETEKD QSIIRIMNSS LKSKNVGGNG ENTYELDKIG YTDLVNAVVF FDDEFVYVHR
MCIMWTLRKK VQIKDPDILQ FLSNLNEYLE QKCSFCGQYG ASITCKMNCR QVHHWPCAAA
AGCFLILESF TVFCTEHLSQ VPLICTDNNV GCLTCSSLGD LSKLIMCCSC GDHFHSTCIG
LANLPDTRSG WSCARCTKCQ ICRQQEANDI KFIKCEQCQK IYHATCLRPV ISSIPKYGWK
CNRCRVCTDC GSRTPGGGSS SRWHSHYTIC DSCYQQRNKG FSCPICQKAY RAAAYKEMVK
CSCCHKFVHS TCDEEADLTA YHKTKEYNPD YDYVCPICKS NSAGAKIVDP LERSLADMQS
SEQFNIKHVE IEPLNGKPCM DVNSEDPLKL PNTKKKVCLT NIRGKGGKFV LHRMGAISQL
GKKRSNRGKG RQLVLQSGSS DRFIGRTMDT DLSSDKKLLL CSARDKFVLS QDICVMCGTL
GIESDAVLIT CAQCGQCYHP YCASVKHSRG MLQKGWRCLD CTVCEGCGKK NDEARLLLCD
ECDISYHIYC VNPPLETVPH GNWKCSFCTI CQKCGRNPTE KVNFNEPSAP ECLPCASQNN
CFVCKKSYTE GDMIIQCEQC EQWSHFLCDS VNTQLTMEYY DNNVYKCMKC RASSKAILPA
NANTNLNEES TAAAKLLPDV PQEGKAMGVA DRNIRLPNEL LESTEAIHWI DGVCLSENGL
NMIKSLSTEI KRKRKMRQPM GNSKDPQNES AISDDVQGDK YKDGMIWDRT ETAIPEGFSI
STNDDGVHVL RKKRQRNLQK LGIGGFSVRN RALKKDNDDT MDQLNAMLVA DKKKKIIRKK
QKNKIIEAYP QYLQEAFFGK PLLESNEAVQ YDSESSDEIG SAVKMYFTPT SEKVPDNDVA
NKSPAKSVKS VKVEKTFNEN KNVFANQFPT ATQQNKKLVT SGAMIDSNMS DISRNAAAPN
MVHSMDTLTT QGIPELDEIN ASINYIASND NTKSTMSEPP LLVENYAVSP QLGHDQKFQN
KMPQNITNKP PQLQYQAKTQ TITTQLPLQT EKRVEEVKPS EPTECINVGT QKTAEKMRKD
EDLGLMATIS AVLYANTEHA NLKESYPNWT DRCKQILKRW RSLCNEKKAP FLQKAKDNRS
ALRQRREQCK VTQPPKLEKQ DDGRAWKNQP CKPKEDQSNM FGGVSYEAPC YIGSSMQATN
SHQQMVISNE NLVVKSTIQR TTMHAGSPSI SKMSSVDNRM EHTTTFESEP VGDKKLRNLL
QKNSSDAVLM NSNSEYFMQN DVLRLGLMQN AALTQNNPML SMSGNPQHTD IRGLEHDGKA
QLDMKITESQ EGISSSAVEL ENVGFGDILG GFGEGDDDDL LKSLTSEIGD DFNILEYADP
ELDVNVLNTL DFDDTEKNST
//
