ID B4L5H9_DROMO Unreviewed; 2196 AA.
AC B4L5H9;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Protein sidekick {ECO:0008006|Google:ProtNLM};
GN Name=Dmoj\GI21512 {ECO:0000313|EMBL:EDW06438.2};
GN ORFNames=Dmoj_GI21512 {ECO:0000313|EMBL:EDW06438.2};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW06438.2, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:EDW06438.2, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH933811; EDW06438.2; -; Genomic_DNA.
DR RefSeq; XP_002010783.2; XM_002010747.2.
DR SMR; B4L5H9; -.
DR EnsemblMetazoa; FBtr0426499; FBpp0384190; FBgn0144242.
DR KEGG; dmo:Dmoj_GI21512; -.
DR eggNOG; KOG3510; Eukaryota.
DR HOGENOM; CLU_001875_1_0_1; -.
DR InParanoid; B4L5H9; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 13.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF49; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 13.
DR Pfam; PF07679; I-set; 5.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 13.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 13.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1974..1996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 227..317
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 325..412
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 421..507
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 512..601
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 608..718
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 723..820
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 825..932
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 936..1030
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1034..1129
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1134..1235
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1240..1337
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1341..1434
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1439..1535
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1540..1642
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1647..1750
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1754..1846
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1849..1956
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2040..2129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2040..2068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2087..2102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2103..2118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2196 AA; 243566 MW; EA6F867D92B62689 CRC64;
MTSGIVKVEH AIPQQQQQQQ QQAGPPTGQS QQQQQQAPRF TTHPSSSGSI VSEGRTKILQ
CHALGSPQPT YRWLKDGIPV ADYSSSQFYR IHNTKREDAG SYQCIARNEA GSIFSEKSEV
VVSYMGTFEN KNEGYLTVVS GHPAIFDMPA IDSVPKPSVS WQAENRTLNY DIKYALTQAN
QLIVLSADEQ DRHAYRAHAM NTQLGREEAS APIHLNVTGD PFVEVAPEII VPPQDLKLKR
GEGVAELQCI ANARPLHELE TIWLKDGLPV ENAGILHTLN NPWNRTLALL QANSSHAGEY
TCQVRLRSGG FRTVTASAHV YILEPPMFFT PMRAETFGDF GGQVMLPCDV VGDPTPQVQW
FRNAERIDAQ LLSGGYSVKA DNTLIIKKLT LEDEGMFQCL ATNEAGEKSA YTWLRVKTSA
PIMEQPPQNV TALDGKDATI SCRAAGAPNP NITWIYNETQ LVELSSRVQI LESGDLLISS
IRAADAGLYI CVRANEAGSV KGEAYLSVLV RTQIIQPPVD TTVLLGLTAT LQCKVSSDPS
VPYNIDWYRE GQSTPIVNSQ RVGVQADGQL EIQAVRASDV GSYACVVTSP GGNETRSAML
SVIELPFPPS NVRVERLPEP HQRSINVSWT PGFDGNSPIA KFIIQRREVS ELEKFVGPVP
DPLLNWITEL TNVSADQRWI VLDNLKAATV YQFRVSAVNR VGEGSPSEPS NIVELPQEAP
SGPPVGFVGS ARSMSEIITQ WQPPLEEHRN GQILGYILRY RLYGYNNVPW SYQNITNEAQ
RNFLIQELIT WKDYIVQIAA YNNMGVGVYT EGAKIKTKEG VPEAPPTNLR VLALNSTAVQ
ISWTPPNPQQ INGINQGYKI QAWQQHLIEG EYQDLEKRMI TVPPSLIDPL AEQTATLNGL
DKYAKYNITV LCFTDPGDGV ISQKVSVMTK EDVPDEITAL HFDDISDRSV TVLWAPPRHA
NGVLTGYTVR YQMRDRPETM KSINLTAEDT QLTVNQLQAT THYWFEICAW TRIGRGTPKT
ATIQSGVEPV LPHAPTNLAL SNIEAFSVVL QFTPGFDGNS SITKWKVEAQ TARNMTWFTI
CEISDPDAET LTVTGLMPFT QYRLRLSATN VVGSSRPSEP TKDFQTIQAR PMHAPYNVTV
RAMSAQQLRV RWIPLQQTEW FGNPRGYNIT YRQVEHKAGT IRHPPRSTLI EDHTANSHVL
DGLEEWTLYE VLINACNDVG CSRASNAAEE RTREATPSYG PLEVEANATS STTVVVRWGE
VPRQHRNGQI EGYKVFYAAT DRVVPVLHKT IPNNSSFTTT LTELKKYVVY HVQVLAYTRL
GDGALSTPPI RVQTFEDTPG APSNVSFPDV TFSMARIIWD VPDDPNGEIL AYQVTYTLNG
SANLNYSREF PPSDRTFRAT QLLPERYYTF SVTAQTRLGW GKTASVLVYT TNNRDRPQAP
SVPQVSRSQI QAHQITFSWT PGRDGFAPLR YYTVQMRENE GPWQPLPERV DPLVSSYTAV
GLKPYTTYQF RIQATNDLGP SAFSRESIVV RTLPAAPAVG VGGLKVVPIT TTSVRVHWSA
LETGMWNGDA ATGGYRILYQ QLSDFPTALQ STPKTDVMGI NVNSVVLSDL TQDRNYEIVV
LPFNSQGPGP ATPPAAVYVG EAVPTGEPRA VDAAAISSTE VRLRWKPPKQ SMQNGDILGY
KIFYLVTYSP QALEPGRKWE EEIEVVSATA TSHSLVFLDK YTEYRIQLLA FNPAGDGPRS
APVTVKTLQG VPSAPLNLRF SDITMQSLEV SWDPPKFLNG EILGYLVTYE TTEENEKFSK
QVKQKVSNTT LRVQNLEEEV TYTFTVRAQT IDYGPAVSEN VTTGPQDGSP VAPRDLILSK
TLSSVEMHWI NGPSGRGPIL GYLIEAKKRE KGEPSFIYDS RWTKIEQTKK GPMQDYTVSY
HILMPSTAYT FRVIAYNRYG ISFPAYCKDS ILTPSKLHLE YGYLQHKPFY RQTWFMVSLA
ATSIVIIVMV IAVLCVKSKS YKYKQEAQKT LEESMAMSID ERQELALELY RSRHGVGTGT
LNSVGTLRSG TLGTLGRKST NRPPTSAQLG KSPPRPSPAS VAYHSDEESL KCYDENPDDS
SVTEKPSEVS SSEASQHSES ENESVRSDPH SFVNHYANVN DSLRQSWKKT KPVRNYSSYT
DSEPEGSAVM SLNGGQIIVN NMARSRAPLP GFSSFV
//
