ID B4LLL5_DROVI Unreviewed; 1229 AA.
AC B4LLL5;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Uncharacterized protein, isoform B {ECO:0000313|EMBL:EDW60878.2};
GN Name=Dvir\GJ21730 {ECO:0000313|EMBL:EDW60878.2};
GN ORFNames=Dvir_GJ21730 {ECO:0000313|EMBL:EDW60878.2};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW60878.2, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW60878.2, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; CH940648; EDW60878.2; -; Genomic_DNA.
DR RefSeq; XP_002049685.2; XM_002049649.2.
DR AlphaFoldDB; B4LLL5; -.
DR STRING; 7244.B4LLL5; -.
DR EnsemblMetazoa; FBtr0434143; FBpp0391225; FBgn0208849.
DR GeneID; 6626456; -.
DR KEGG; dvi:6626456; -.
DR eggNOG; KOG3515; Eukaryota.
DR HOGENOM; CLU_003881_1_1_1; -.
DR InParanoid; B4LLL5; -.
DR OrthoDB; 2875972at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:EnsemblMetazoa.
DR GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005768; C:endosome; IEA:EnsemblMetazoa.
DR GO; GO:0098631; F:cell adhesion mediator activity; IEA:EnsemblMetazoa.
DR GO; GO:0008407; P:chaeta morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0001751; P:compound eye photoreceptor cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:EnsemblMetazoa.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:EnsemblMetazoa.
DR GO; GO:0061330; P:Malpighian tubule stellate cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0007520; P:myoblast fusion; IEA:EnsemblMetazoa.
DR GO; GO:0007220; P:Notch receptor processing; IEA:EnsemblMetazoa.
DR GO; GO:0016318; P:ommatidial rotation; IEA:EnsemblMetazoa.
DR GO; GO:0010950; P:positive regulation of endopeptidase activity; IEA:EnsemblMetazoa.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:EnsemblMetazoa.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR PANTHER; PTHR11640:SF136; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 5.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 9.
DR SMART; SM00408; IGc2; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 9.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1229
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006457287"
FT TRANSMEM 1039..1064
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..130
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 135..238
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 245..335
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 340..435
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 442..532
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 537..631
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 638..728
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 733..820
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 827..924
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 931..1022
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 1229 AA; 133847 MW; F403DE38B11643B8 CRC64;
MQFWISLTFA LLSVGVTCSG QVVTPSAASP AVQKFRVTPH DLQILEGTDT LMRCEVSSRA
GKVQWTKDGF ALGFSAVIPG FPRYSVLVDA AHGIYNLQIK NATLEDDAEY QCQVGPAAGN
PAIRANAKLS IVAAPSSISI DGYARNAKVE VIESQNLTLQ CITENANPAA EIVWYQGETP
MTLAPIVSIN QTSAKRFRTS STLHLQPRSD DDYKEFSCEA RHKALPPDVP MRAQVQLSVL
YPPGPPFFEG YSQGETLRRG QEVQIACRSR GGNPPAQLVW YRNGEVINSP QRTSGRLSEN
VYKFTANTSD NGANLVCEAK NLLSNTPLRA ELNLTVLYAP KDVFLSGATH AKVGDAVELN
CVTAPSNPPA RISWSMNGRP LSNSTYKTTI SADGGWVSSS NITLNIDSQS RTFITVCHAL
NAELSQNVVG SHTVNVLYPP SPPLLTGYND GDILISGSIL KLQCSSAGGN PPPALQWYKN
DKRLNAASKV TDNKISSELS LLVNASDNNA IYKCEVQNAA IEIPLFATKT LGVHFPPETV
KISVAPKNLV PGIRAKLICD SSSSNPPAKI SWWKDGIPVE GLNLANRPGL WGGSVSTLEM
HVNITQDLDG SIYTCQSHNE VLQRSVHETI SLDILFPPKF DVAQITSFVG VEGAPLQVEL
HASGNPMSIS YTWTKDGLPI SSNPLSGQRL ISDGPRLNIS RLSRNDAGVY VCEALNTQGT
AMLEIQVIVE YAPIITSVTE GQSFASGAQA VLACQVQARP LEAAHVRWSR PGYDLATRTT
STFENNTALL HIDNVQRGDI GNFTCTVDNQ RGPAASKSVV LVVQTSPEID HSPAYTRFAA
RLGVRAQLIC RALASPQPSF IWRRHGKDLK MQRRNKFTTV ERQVDPLHFE SALLVESTSA
DDYGQYECVV RNSMGQASTT LEFSKPTRPD TPLQLRVGNV SDTSVELMWT PGFDGGMQVY
YRVRFKQQGE DKYKYMDAKV GQQNITLEGL KPGGTYFYSV MAHNEAGGSK FLPDIKLTLS
KGSQPHSAEY TEKDELPNVM IIGITSAAMV LLVLNAALVA WFVIRRQNKT QGETEPSNDD
AYSKDDNQSV YKLPITALQA DVQKKAAAST YLVENVDIIQ STAYPPKYQE SSMCTPPYPL
CNPDFTRTLP NPKRHSQRNS ATGLIEGMPM RAKDDHMLIS NGLYIPSPSP ASSLVIKGSY
ISSPSPAPPA DGSYFNMSDK YMSYPPVTY
//
