ID B4LXN3_DROVI Unreviewed; 2247 AA.
AC B4LXN3;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 24-JAN-2024, entry version 100.
DE RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN Name=Dvir\GJ23804 {ECO:0000313|EMBL:EDW66817.2};
GN ORFNames=Dvir_GJ23804 {ECO:0000313|EMBL:EDW66817.2};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW66817.2, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW66817.2, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH940650; EDW66817.2; -; Genomic_DNA.
DR RefSeq; XP_002053297.2; XM_002053261.2.
DR STRING; 7244.B4LXN3; -.
DR EnsemblMetazoa; FBtr0445061; FBpp0401352; FBgn0210900.
DR GeneID; 6630623; -.
DR KEGG; dvi:6630623; -.
DR eggNOG; KOG0644; Eukaryota.
DR HOGENOM; CLU_001108_1_0_1; -.
DR InParanoid; B4LXN3; -.
DR OrthoDB; 24713at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0035072; P:ecdysone-mediated induction of salivary gland cell autophagic cell death; IEA:EnsemblMetazoa.
DR GO; GO:0035096; P:larval midgut cell programmed cell death; IEA:EnsemblMetazoa.
DR GO; GO:0035562; P:negative regulation of chromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:EnsemblMetazoa.
DR GO; GO:0010468; P:regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0046532; P:regulation of photoreceptor cell differentiation; IEA:EnsemblMetazoa.
DR CDD; cd05529; Bromo_WDR9_I_like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16266:SF17; BRWD3; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR Pfam; PF00400; WD40; 8.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 179..220
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 221..262
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 263..308
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 365..400
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 421..462
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 463..505
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1228..1298
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1390..1460
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 709..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..2231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..924
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1494..1508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1533..1547
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1550..1592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1598..1618
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1713..1728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1751..1794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1836..1850
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1878..1892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1907..1928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1943..1963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1997..2030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2041..2060
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2072..2086
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2087..2123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2163..2191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2247 AA; 250377 MW; 0F02156C2B152DFD CRC64;
MENRQPSLND VIVPELYFLI SKFLTAGPLE ETAKVLVQEL EQKKVLPRRI DWLGNEHEQT
FAELEQKYAH IGPNHLLEIC SRLGPLVDKE LAPSVPGITS LLGTGRQNLL RTKDTVYRHR
TLRDYCTRLH GISLPDSRLT KPTHNLAKVI TGREHGGVVR RKLLVPTDLY RKTKLLRRTV
GHLSSVYCVL FDRTGRYIIT GADDLLIKIW SAADGRLLAT LRGASAEITD IAINLDNTML
AAGSVDRILR VWDMQTTSPI AVLAAHTGMI TSVNFCPSPR SDLKYLVTTS TDGSIAFWQY
STPRGQKITF APRPTQYHEK LRPGQAQMMC TTFSPGGMFL AAGSADHHVR VYMMAEDGPK
RILETEAYTD AVDSVQWSHR GLRFISGSKD GTAHVWTFES QQWKSIKLCM TERLPSCPEP
EEGKKLKVTM VAWDASDRYV ITAVNDFTIK IWDSKSAKLH RVLRGHKDEL YVLESNPRDE
HVLLSAGHDG QVFLWDIEQG VGVAQFFNDI DGQGHGSVFD AKWSPDGTMI AATDSHGHIL
IFGLGIGTDK YKLLPTELFF HTDFRPLLRD AHHHVVDEQT QIMPHLMPPP FLVDADGNPH
PTKYQRFVPG RESCSTDQLI PNLTVGIDGI VIEDNINAPP NAAAAPGPAA APVAGVGGGA
AGAVGAGGNY SHIDRMIAAL ANRQGNNANA NDANNANQSF ERLIMRQGQD HMPDSNSSRN
TPQRGNVLGG RRSLAEGAPR QGWAAALPVA APAVAEQAQV EPRLALPAQQ AMPLKFVRRT
YVRPMKYAQL QNLKQTIYSI GQYEMQEYKR EMRRRPIMIN TASAASALLA GVGRPRNTRS
NGAGRPGRRR GAQSGQQQQG GQQPAYRTRA VRGQEEHYDD AAAPAAHEEE EEDDSSNSSG
DTSYSNVEEN LEDSSDESET DSSDYSDWVA DTPGPNLEPP KRSKRKPLSR RRTISDDSSD
DATPGNTAVG NKKRGRKRVL IPPTTPNGEI PELYRPAEWL SEVIPRKAPY YPQMGDEIVY
FRQGHQRYLE AVRLKKVYKL SHSSEPWNFR TLRDHELVRV IGIKYEIRPP RLCCLKLAII
DDEGNMTGTT FKIKYHDMPD VLDFLVLRQT FDLAVQRNWS ISDRFRCMIG DGWWMGQIES
RHALSADFPD SFFMCFRVRW DNGEYEYMSP WDMEPIDEQR LPDEVGGAVP VLPEEIRATL
YQPKSEEWHR GDRDGTCRRI INGLEQVMRL SIAEHFLAPV DLNIYPDYAY LIEYPIDLTT
VKSRFENHFY RRITSAQFDV RYLATNAEQY NRRHTSIVKH ARIVTDLCLR IIREADEIDV
AAVYHQLVDV YHSSESENEA DSDVVPSTST GPTTSAAAAR QRVSSTRRSN RIRSDGDWRS
DCRQLLDMMW QRPDSLPFRE PVDTIEFPDY LEIIATPMDL RTVKEDLLGG NYDDPLDFAK
DVRLIFLNSK NYNTNKRSRI YAMTLRLSAL FESHIKTVVS SWKAARRRAN KNKSGSSGRG
SSSPSKRTPT DRTTRRTQKP PGAARRLPAH TSEEDEDDDD DDDDDSVAPQ QQVPRGTQRG
SRRRNGVAVS ATISSSNRVT SSSSNPQQRR HESSSNSESD EEEEEEETTS DASSDDNEDE
EAHSNGSSPQ HTRRRRGRVA RQNVSDDETN ANDSEESYNP NERRRGRAGG GGGNKRKPNS
RLHHSNKRHR VDQTVQPGGS RGATVAPTRR TRRLLGSSED EHQAEASHSQ PDDSTQDSQT
TRKKGRPAKN KSATATGNGP GTSAAAVSAG SSLESPSRNT RANGGRSQNA AENDHSYHLP
VRNGRIIDSD TDSHGPVGRP TRQSAKRAIM DWARGSDIEE EEDDESEEAE EILPTPTKDD
MPSTSRAALG HVAGAATSAR QLRTNRNTVV TAAAESDDDD DSDNEPLANN QQKTATGPAK
TSTSAPHPLT LRRRLPSVPR SMHMTRSHAT STTNSSNQQE PAMAAHDHNY LGSESAAASR
APRRVLSRHQ RNADELDTTN DPLNSSRLLS ILSNHRRPTS TTNNVTTRRL RSRNSQEHSQ
GEEEDEEAAE LPDGEEAAAS DEGTDGGSSS QGSNDDDDDE EPTATDSEDN QPLTSYVSPS
NGRTSRKTKT SSSSAATATQ GREQRQRRQL RATSDQSLND DDDDDYEAPR GRLRSNQRSG
RNQKRPRYNE QSDEDDQNQG HSQRKRLRNG DVHTATNNSN SSQEREEQQR TEDGNSSTAE
SDEQLVSVSS RGRVRKISAK ARGIFKD
//
