ID B4M079_DROVI Unreviewed; 1519 AA.
AC B4M079;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Uncharacterized protein, isoform A {ECO:0000313|EMBL:EDW67241.1};
GN Name=Dvir\GJ23193 {ECO:0000313|EMBL:EDW67241.1};
GN ORFNames=Dvir_GJ23193 {ECO:0000313|EMBL:EDW67241.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW67241.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW67241.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CH940650; EDW67241.1; -; Genomic_DNA.
DR RefSeq; XP_002053721.1; XM_002053685.2.
DR SMR; B4M079; -.
DR STRING; 7244.B4M079; -.
DR EnsemblMetazoa; FBtr0239118; FBpp0237610; FBgn0210295.
DR GeneID; 6630446; -.
DR KEGG; dvi:6630446; -.
DR eggNOG; KOG3766; Eukaryota.
DR HOGENOM; CLU_002164_0_0_1; -.
DR InParanoid; B4M079; -.
DR OMA; WDDCYDL; -.
DR OrthoDB; 2905251at2759; -.
DR PhylomeDB; B4M079; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR GO; GO:0031523; C:Myb complex; IEA:EnsemblMetazoa.
DR GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IEA:EnsemblMetazoa.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007281; P:germ cell development; IEA:EnsemblMetazoa.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0042659; P:regulation of cell fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0007347; P:regulation of preblastoderm mitotic cell cycle; IEA:EnsemblMetazoa.
DR GO; GO:0035190; P:syncytial nuclear migration; IEA:EnsemblMetazoa.
DR CDD; cd20101; MBT_L3MBTL1-like_rpt1; 1.
DR CDD; cd20102; MBT_L3MBTL1-like_rpt2; 1.
DR CDD; cd20103; MBT_L3MBTL1-like_rpt3; 1.
DR CDD; cd09509; SAM_Polycomb; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR PANTHER; PTHR12247:SF131; LD05287P; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF02198; SAM_PNT; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REPEAT 805..904
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 912..1013
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 1020..1115
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 1295..1384
FT /note="PNT"
FT /evidence="ECO:0000259|SMART:SM00251"
FT REGION 280..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1408..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 764..803
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 280..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1206
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1476
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1519 AA; 168502 MW; 8C51F064E524EDFA CRC64;
MLPANLGAAN VSQGKREVPI TMSPVKPGNN SGVSGGTLTA KATSKAPEEL RYLPIATMPT
KPCNITISSY KTNNNNCSKN MNNNAAAIKT KLTPMNIVQK QLKASNNNNN NNSSNNNITA
AAPPLIQLVA NSSNGNANSL LSILSPKTLI KPASNNSNGQ ATAQSQTQPV LIRPATTMTT
IPVQQQNGAN HNSNSSGAAA TAAAAGTVAP SHLISLVAAK TPSKTAAVPA SSAAAQISLL
SKSRTPVILS KAAVEKIRLK FGQVQAQVNA GALFLTKSIK TSGTNTNNTS NSNNKSGNSR
PAQETAGATQ PAAQKPTGVV ATSTSMPTPM PAPMPTPMPA PMPTPMPLPM PMPSNALPEI
KISPVSAVAL NGAKIMKVQA SPLAVIMPTV PAPAQAPTAT TTATATIGQP SVQQGSPKLQ
RSKSLAGNEE NAAVILIQSN ATERRHSVAI MAKEVDVVEQ TKPIETITIE DDDSDEEKEA
QIKQQQAKRQ QQAQIMQQQQ KPQQQQQQKT PTTSTQTSRK NSTASRSSIT SSSSSDVEMI
IMPEEVRPKQ LETKQPANGA IINIVKAETL SLSKEEFETS LRCDEHVDNS SPSSVCTNHT
SKSGTITLTP ISRLQHNGVE PKTGAAVTLN TFKRSMQQHF GMLRWREKQP GMLQNSTMRF
ELNRYNLLQL AERCDSRQGP ASYFERALFD RPVRRPNSTT HPLLYLCSRC NCHGPASDFL
APRFCSLSCV RRAHKRRQLN PPSAASESKI SRMQEPKLVQ NGHLQQQQQQ LQLQQQQHQL
QLQQQLQREQ ERERERKSTA AKRPFRWTEY LKLKTNGDAA PIHLFLNPFP IKPNCFKRGM
KLEAIDPENC SLFCVCTIVE VRGYRLKLNF DGYSSMYDFW VNADSMDIFP PGWCERTSHV
LQAPKGYCPD RFTWYRYLVK TKAKAAPSTL FTHLNATKHT QINNFSVGMH LEAEDLNDTG
KICVATVADI LDERIRVHFD GWDDCYDFWV HINSPYIHPC GWHEGRQQLI VPPDYQNIMF
NWADYIEEVG GIAAPADLFK PREPMEFQAR MKLEVVDQRN PCLIRPATVV TRKGYRVQLH
LDCWPAEYYF WLEDDSPDLH PIGWCEATSH ELEVPPGFQQ RASLMPCDVA GCRGFGNAKR
FNLNVHALRD CCPYAPENWR QWRAKTVKPP RVLPEHIKRT ESPKPQPQPL PLPQQQPLPQ
PQPVKTPSPI LESQLNTNLK PAVVKGKTYG KPKKSRPSLD CEPKPKLKRE EPKPLSVEVK
PEPVPKSAEV EPMDLNPHCL SIAKTIVAEY GPQFARNYRL WQKNSDFDMA QLKSNPLYWT
NWDVYEFVER ALKSSSIAQL LFDEEIDGRA LLMMGRKDLA TYFKLKVGPT VKLFSLIVNL
RIAVACKFAT KETGLNFNRV RCSTLPGKQE SVENKPELKT DNHLTATPNG LEQAELVDSS
AEQENLKEER DEEEYENDVD YDYSEQPERE LTDEEDVVLD SEDFLSVKPL HSIVNNVRTI
EDTDSDVTMT PLDVLPVSV
//
