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Database: UniProt
Entry: B4M858_DROVI
LinkDB: B4M858_DROVI
Original site: B4M858_DROVI 
ID   B4M858_DROVI            Unreviewed;      3051 AA.
AC   B4M858;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   27-SEP-2017, entry version 67.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW62334.2};
GN   Name=Dvir\GJ16667 {ECO:0000313|EMBL:EDW62334.2};
GN   ORFNames=Dvir_GJ16667 {ECO:0000313|EMBL:EDW62334.2}, GJ16667
GN   {ECO:0000313|FlyBase:FBgn0203851};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW62334.2, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:EDW62334.2, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH940653; EDW62334.2; -; Genomic_DNA.
DR   RefSeq; XP_002056848.2; XM_002056812.2.
DR   STRING; 7244.FBpp0231084; -.
DR   GeneID; 6633654; -.
DR   KEGG; dvi:Dvir_GJ16667; -.
DR   FlyBase; FBgn0203851; Dvir\GJ16667.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   InParanoid; B4M858; -.
DR   KO; K04854; -.
DR   OrthoDB; EOG091G02L1; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   Bgee; FBgn0203851; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    246    267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    287    308       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    329    358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1229   1251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1321   1345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2021   2039       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2059   2080       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2092   2111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2156   2178       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2259   2282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2339   2360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2372   2396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2472   2492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2557   2583       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      210    524       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1098   1354       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2020   2292       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2338   2592       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1907   1938       {ECO:0000256|SAM:Coils}.
FT   COILED     2583   2606       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3051 AA;  335809 MW;  B568971A6752197E CRC64;
     MASDVAQKLR RSASASGSSG QQRVRKTSSC SASAKTTPTP HSRRPHRQHS NASDSMHKQQ
     HQQQSQQQQQ SQQQQQQQQQ QQQRRYQQSS RAGSKERGSE TARRRGTRRH SAASMQSEAA
     TATGTERGTE RGQRSGQRAR GTSSAASSST ASSCNSSCSS DDGDSTHSSS SSSSSSGEPN
     LPYPGFPEIA MKALTQYTRP RNWCLMLITN PWFERISILV ILLNCITLGM YQPCVDDTCL
     KPRCKILQIF DDIIFAFFAL EMTIKMVAMG MCGKNTYLAD SWNRLDFFIV LAGLLEYVMH
     VENLNLTAIR TIRVLRPLRA INRIPSMRIL VMLLLDTLPM LGNVLLLCFF VFFIFGIIGV
     QLWEGILRQR CTLERPDGMI YPITGLPEVY RVRVRVNSLS QYYEFSKDQD YICSTPEDSG
     MHLCGNFPPY RICLIRLPRE AKLLDLNEPT NTSCVNWNQY YTTCKQSGEN PFQGTISFDN
     IGMAWVAIFL VISLEGWTDI MYYVQDAHSF WDWIYFVLLI VSSSYDSWCS PHFCRYQRQQ
     RREGLLPNAD NLTFSPSRIK CHHPNCPKYS SRKPPSIQDQ MITVMVPLNS NNNNNSHNNS
     NNNSSSNNGS GGGGSGGNHH SHNHTTVALV NGINGSTASV SMTQQQLTAP IGGAAGGAGG
     AASQAQLSSS DNTEQSLGEG SAGGSGVARR SSSLRKPNAQ HSHSIQLKPE MAGGEQKTIL
     LKLPQQVMDS EQLILQLGNL GKSHPCTSGF LSPPTSASRR PSVMFNEYVL LHTPPALSGE
     PTSSAAAAVA TTSATATATT SAAAAAAAAA TTAAATTSNG SGSSSIQLAE KGNIHSTEKM
     TQAGDGSIWQ VNLPQTIGTI ANPYADCSEL GIHDAMTCQE LLAFSVAFSA ALPTGQSTLE
     SFYSSLARCD PHTAEALNKV QQKRATAATT SAAAAAAAGA AAPGDSLDAN AELPAVPATM
     SVELAAVSAA VPLPMPLPHA EPHLQSRRKA QHLPHNNNNN NNNSNSNNNN NNKNNKNTGH
     SRSHGQRSAG HVSRSHAPTG NYMEDYACCY DLYQNALSPL DERQRPRSGA LRLIIAVYRC
     LMRVCSWIRR YIKRLVEHKY FQQGILLAIL INTLSMGIEY HNQPEELTAI VETSNVVFSG
     IFAVEMLLKV VAEGPFRYIA NGFNVFDGII VILSAIEICQ TFAGNGTGGG GSGLSVLRTF
     RLLRILKLVR FMPNLRRQLF VMLRTMDNVA VFFSLLVLFI FIFSILGMYL FGGKFCKFLD
     ESGLERECTC PEIISRHPQC ECDRKHFNNI LWATVTVFQI LTQEDWNVVL FNGMEKTSHW
     AALYFVALMT FGNYVLFNLL VAILVEGFSS ERNERREREQ RELVKKLREE TLAENYSDGM
     YDESRSEADS STTNDSYYEV RNRWRSAEDV RKQLQDSAEL NIETKSNIHR QRLLQPIQDY
     QINELPAQGA SASVLGNAAA GSGLLPSDKE AGSKAHEEAK PRGGLKKTYS IKERRSEAPR
     LTKMRLIRDP PLITTTAATP QDSPSTTMEP GMSFRQWGDM EPVPPSPSLL KPPNIFSGGQ
     RTLDEGIPAI DLIPPSPVLA HKPLNILNAG QLQGHVSPVG NAVGAGGAAG GGSVGATATA
     PAAVGGSGGA SASISSGSSN QLSNLLPSSV HSVNIDDISK NSSTTAAATP IYVPSISSTA
     ATLQPPTESH SHSLNLSDLS PLTVSLTGST SSPMGGAGSA ASTSGSSSSE RLPLAPPSGS
     FQQRFRRSSS KKRPTTLRPD DNISAPDDEQ QQQQLNSSGA VESRHRDTNR LSPQNSMRRL
     SNTLSIGSGP GSRRASACIF NSQVYQNLSQ PPKLRPGAGQ RRMSSIELAF SKTSHLNLHN
     LEANRKSLSY TNSKIDLDKW QRSYLTLNEP DMLQQYMEAR DKRKNSISHY NLKKRLEEKE
     LQQLQQLHQQ QMQQQQQQLD TQSHTQLSPQ QLAKELQLLS MQQQHSMVPC GGGEHVSKLR
     MIIQRLTPKQ FTAERESYSM YVFPEDNRFR QICSWFVNQK WFDNVVLLFI ALNCITLAME
     RPNIPPSSTE RVFLATANYV FTVVFTIEMF IKVVATGMFY GPDAYFTSGW NIMDGSLVTI
     SIIDLLMSLI SESSPRIFGI LRVFRLLRSL RPLRVINRAP GLKLVVQTLL SSLRPIGNIV
     LICCTFFIIF GILGVQLFKG TFFYCEGENI KNVRNADECR RIPGNVWTNR KYNFDDLGKA
     LMSLFVLSSR DGWVNIMYTG LDAVGVDQQP IVNYNEWRLL YFIAFILLVG FFVLNMFVGV
     VVENFHRCRE EQEKEEKIRR AAKRALQMEK KRRRMHEPPY YTNYSPTRMF VHNVVTSKYF
     DLAIAAVIGL NVVTMAMEYY KMPMALQYAL KIFNYFFTAV FILEANMKLV ALGWRLYLKD
     RWNQLDVGIV LLSIVGIVLE ELETNIIPIN PTIIRVMRVL RIARVLKLLK MAKGIRALLD
     TVMQALPQVG NLGLLFFLLF FIFAALGVEL FGRLECSDEI PCQGLGEHAH FANFGMAFLT
     LFRVATGDNW NGIMKDTLRD NCDDAADCVR NCCVSSFIAP IFFVIFVLMA QFVLVNVVVA
     VLMKHLEESH KQMEDELDME VELERELVRE QEFAQEQKLC QQLAEAQAKL IAPPRPLAKV
     KSLPKNFIYS TPSLEKKFPS PSLTGSSATN LNQTQSGAGA RRQTVQYFNQ QQQQQQHALG
     LGLSLAEMGG ALTPQALGAR LGEPFGGAVT AAAITGNEHG LQLPPLGRRG RRASAAAGFR
     KRGVLSKERS LDEQAIRRRN LEAKRTSCDS LPWGGDALDY RRGTIFESLE SDGGGNSPSS
     SYDLDVRSIR SAELSRPRDD DLPLAILSAP TPTPTPTATP LAIVMPTTTP TATPTATATP
     TVTHQQRRPF GWSQSVDQSC LLGAGGRNSL LLSVPRSMPP RSRSGSTKQL FKQQALDEDA
     DLDENSLLLP AMPQPATAAA TATAQLPSSD SCPTAVGKGN ADSDTHAHAH ALGDGDDVNS
     VDCPAISKSD SADIMRIISE RRRMDQRDQC GNEDSDYNEL LLVKSPQSST D
//
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