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Database: UniProt
Entry: B4MA91_DROVI
LinkDB: B4MA91_DROVI
Original site: B4MA91_DROVI 
ID   B4MA91_DROVI            Unreviewed;      1256 AA.
AC   B4MA91;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   30-NOV-2016, entry version 55.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW66150.2};
GN   Name=Dvir\GJ15708 {ECO:0000313|EMBL:EDW66150.2};
GN   ORFNames=Dvir_GJ15708 {ECO:0000313|EMBL:EDW66150.2}, GJ15708
GN   {ECO:0000313|FlyBase:FBgn0202896};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW66150.2, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:EDW66150.2, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00534092}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR   EMBL; CH940655; EDW66150.2; -; Genomic_DNA.
DR   RefSeq; XP_002058042.2; XM_002058006.2.
DR   STRING; 7244.FBpp0230125; -.
DR   EnsemblMetazoa; FBtr0231633; FBpp0230125; FBgn0202896.
DR   GeneID; 6634643; -.
DR   KEGG; dvi:Dvir_GJ15708; -.
DR   FlyBase; FBgn0202896; Dvir\GJ15708.
DR   eggNOG; ENOG410IPBB; Eukaryota.
DR   eggNOG; ENOG410XVGZ; LUCA.
DR   InParanoid; B4MA91; -.
DR   OrthoDB; EOG091G02JI; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR032695; Integrin_dom.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF00357; Integrin_alpha; 1.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SUPFAM; SSF69179; SSF69179; 4.
DR   PROSITE; PS51470; FG_GAP; 7.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00440260};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Integrin {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494682};
KW   Membrane {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494691};
KW   Receptor {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00440269};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Repeat {ECO:0000256|SAAS:SAAS00504086};
KW   Transmembrane {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494686};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494657}.
FT   TRANSMEM     20     38       Helical. {ECO:0000256|RuleBase:RU003762}.
FT   TRANSMEM   1086   1108       Helical. {ECO:0000256|RuleBase:RU003762}.
FT   DOMAIN      485   1006       Integrin_alpha2. {ECO:0000259|Pfam:
FT                                PF08441}.
SQ   SEQUENCE   1256 AA;  140264 MW;  2AE5EE83943A2667 CRC64;
     MTAPPLRGTS PRSNHGESRI LIALNVLLCI IFAATAVSCF NLEQRQPLIK YGHPNSNFGY
     SLATHTIGEY NWPNNTKCLL VGAPLDRNRQ PNTNESGALY RCPISTDFND CEQVITDGRR
     SSGGAYEPTY DVDELIPPSS DEIKEGQWMG VTVRSQGLGG KVLVCAHRYV TIVRENRYGQ
     GLCYVLTNDL QFDEVYEPCK GRSVQRQHED YGFCQVGTSG ALLDDNTMVL GTPGPFTWRG
     AIFVTEIGGE YLERDKNMYY SDHSDASSPV DKYSYLGMAV TGGRYFGERM SYAAGAPRSN
     GHGQVVIFDK ANTSPIPVRL IIDGEQFASS FGYELTTADI NGDQKPDLIV AAPFYFAKSD
     GGAVYVYQNA KDMLPKQATL RLTGALESRF GLALANIGDL NKDSCEDLAV GAPYEGDGVV
     YVYLGSKQGL NEKPSQRIQA SDLGRNLPQP IRTFGISIAG NTDLDGNSYV DMVVGALPSV
     VVLLARPIIN IQTTYRSNET RNIDPNRAGC RMDVSTNLTC FTFEACSSID PHEQLTKELN
     LILTAEAETF EHHKKFSRAF FDRENKRSNV ISRQVRVRTD GRVECQMVTG YIKANTRDIQ
     TPIRFRLDYK LEEQQLADSP LERLNPILDQ TQAYIEFEGT FQKDCGDDDL CESDLRLHAE
     PNLTAEDGQY SLIQGNKTEL EVMVNVSNLA DSAYEAQLFI VHQKSVSYIA TKKPTNATCN
     SFNTTLVACS LGNPMLRGTT THVTIRFDPN SLELEESQMV FHIFANTTSQ LVGQQPPERR
     LTVQMVRRAE LTVRGWVNPE QSFYSGAAKL QDSPMELDDV GSPLMHTYSI FNEGPSAAPK
     VQLVISLPLM LESGQGQELE QGAKDQYLQY LEDKPTIETG QGECTVAPEY INPLKLASKV
     PASLRSAAYL NAPASMTKWP LHRQASPTPS KSLNLSQSQG QTQHWSQHKS GQDYGRANRL
     PRNTLERIVR PERFMDGREA GVKGKKQQIV ELNCDKLTAH CIKIHCEFFA MPAKTEAQVT
     LKARLWNSTL VAQYPRVDLV RIISTAHVKI PQNFGVEQLE NNDNVLVETR AYPELLDQQR
     ETHTPLWIYI LAVLGGLLLL GAFTYAMWKC GFFKRQRPTD PTLSGNLEKM NEEKPFLGAK
     SSHNVFXQEG TVGWDLVRRI APARKRNRLR LRLRLRQLLL LHSQPHYKQQ QQQQQLTPPC
     GCSWRNNNNN NNNNNNNGSE DEFDVLSLTP PPPPLSVLSW GSDGYYQASA AWWGHM
//
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