GenomeNet

Database: UniProt
Entry: B4MEC2_DROVI
LinkDB: B4MEC2_DROVI
Original site: B4MEC2_DROVI 
ID   B4MEC2_DROVI            Unreviewed;      2890 AA.
AC   B4MEC2;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   27-SEP-2017, entry version 64.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dvir\GJ18955 {ECO:0000313|EMBL:EDW58887.2};
GN   ORFNames=Dvir_GJ18955 {ECO:0000313|EMBL:EDW58887.2}, GJ18955
GN   {ECO:0000313|FlyBase:FBgn0206101};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW58887.2, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:EDW58887.2, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH940662; EDW58887.2; -; Genomic_DNA.
DR   RefSeq; XP_002059475.2; XM_002059439.2.
DR   STRING; 7244.FBpp0233372; -.
DR   GeneID; 6635853; -.
DR   KEGG; dvi:Dvir_GJ18955; -.
DR   FlyBase; FBgn0206101; Dvir\GJ18955.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; B4MEC2; -.
DR   KO; K21862; -.
DR   OrthoDB; EOG091G01WJ; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   Bgee; FBgn0206101; -.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028820; Na_channel_60E.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF257; PTHR10037:SF257; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008792};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    153    171       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    191    211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    246    266       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    688    706       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    752    776       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    796    827       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    885    910       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1759   1779       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1788   1810       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1816   1838       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1870   1896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2021   2045       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2107   2127       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2133   2154       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2166   2184       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2223   2251       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   2322   2346       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      126    405       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      687    917       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1755   2054       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2106   2356       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2362   2423       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   2890 AA;  326700 MW;  DFB265B602A483AB CRC64;
     MSDDQTLAAQ NEDKVAKQQV VAYTQKSQVK HETRHIQLVR EYGFHPRTKA SVEDGDVLPR
     KFEPFPEDMY GKPLEEIDTF IYEETFCVVS KRFRKNYIHR FTGTKSLFLF HPWSQWRRVC
     VYIATNQFFD YCVMATILFN CIFLAMTETV EEAEYIFLAI YSIEMVIKII AKGFLLNKYT
     YLRNPWNWLD FVVITSGYAT IGMEVGNLAG LRTFRVLRAL KTVSIMPGLK TIINALLHSF
     RQLAEVMTLT IFCLMVFALF ALQVYMGELR NKCVRNVPTD WTNISHLDWK IWVNDTDNWL
     YDDEELPTIC GNLTGARHCP LGFMCICVGD NPNHGYTNFD NFMWSMLTTF QLITLDYWEN
     VYNMVLAACG PMSVIFFTVV VFFGSFYLIN LMLAVVALSY EEEAEITNEE RKKDLLDHRD
     DSTFSFDPSV LNVKKLSKNN KKKIDSRKGV LLASYSKKKT RRKKTKGGKD NTSNNGSNGV
     EQEHIKSLSA TPSPGPSPRN STTERPSALA LQAQQQMEQQ QQQQQQQQQL VQTETAATSQ
     SKTRISFREG SIKNPNMLYP SDYKGQLMTS SRQTSSNSSG GVNRESSQDD SGVVDDHEEQ
     DTANEMGHVS TVELALSPRE VRLIKCNGNI ARIKNHNVYA LHQEYSSEVV VIDDLPDRNC
     DRCVHCCADY ESWLQFQNCL YKVVRDPLFE LAITLCIVLN TAFLAMEHHG MSESFRNALD
     VGNKVFTSIF TFECIVKLMA LSKEFFLCGW NIFDLIIVTA SLLDIIFELV DGLSVLRGLR
     LLRVLKLAQS WTTMKVLLSI IISTIGALGN LTLILVIVIY IFAVIGMQLF SKDYTAEKFA
     PDPVPRWNFN DFFHSFMMIF RILCGEWIEP LWDCMRAEEE QGASTCFAIF LPTLVMGNFM
     VLNLFLALLL NSFNSEELKS KKEEVGEESK LARSIERVRD LIRKKRQERK DRKERKYAEK
     FQQIVLEAQQ AHVAAREMDK SGLLAETKFH RLSYQESMNR PVSGSDFGFQ IPLSDGLHTI
     VDGLEYDETA EAADQQQQQQ QLQQPAADYL PPTYECAMLS ATSNGNSNGG DNNLTSMAGR
     LQHQISSGVG TQQNDSRDEA TYTESIELRL LGQYNSTDTD PYAYAADQRS GSFARGDSLQ
     DTDEAYLKYQ KSLLTRSPSY RKSLDRLSQS SGQSQRSLLP SRSLKSEESA MRRHSSGHSL
     NSISLEQDEL LSQQANLREE LLNCDQKELF QFLQEDDELL AKKKTTTSSI KSNLSYISNS
     IMQTLDSRHS STGNGQQESE PLMEHSEFDN IIQSFEKELE EIKRSTSSLE RKISTLAEPS
     PAADEATKAI MDHIAVITGA SERTAADEVV HPLNPYDSYD LSSVPRRSQS VSAAAQRQSV
     KLKRRSLEKQ RKIDEDFSIS NEIRKICDQI HAPFAAMEAL AVAATSGSSS TGGGQSPFMR
     RKNDPFSVQF DRFKRLSLIE RVEELPEEDK PISTLRIESE KMPRKFHNSE QLRLDSLSLK
     STNSYENLLI QKQQMCREAN NPNGGVPATP PTSLKSSIEP PTLAQISSLK ATPPLAALTE
     HQQHYHATSI QTTIATTAAA TKTMHPTAVG AGASKRRAEH PQSRLDKAAS FQSGRTESRS
     SGAADNSSSA HAGPRSMSNG QQPERASEKT EPMAATTKPS AFSRLTEKPW HCLVSYVDDL
     TVGGRRNSQG AYNDPMTFPS YGQTKPAKVP DDCFPQKCYD HFYFRCPWFM SCMDTPSAKH
     WTRVRTAVLT VVDTPAFEWF VLVLIFASSI TLCFEDIYLD SNKTLKRVLY WTNFSFSLIF
     VLEMVLKWLA LGFSKYFTSF WTILDFIIVF VSVFSLLIEE NENLKVLRSL RTLRALRPLR
     AISRWQGMRI VVNALMYAIP SIFNVLLVCL VFWLIFSIMG VQFFGGKFFK CVNELGELLP
     ITVSMPNRPP QAGESQLPNH IAQAPINMFS ICNLQEVNDK WDCIEQNYTW INSKITFDHV
     GMGYLALLQV ATFEGWMEVM ADAVDARGVD LQPQREANLY AYIYFVIFIV CGSFFTLNLF
     IGVIIDNFNM LKKKYEGGVL EMFLTESQKH YYTAMKKLGR KKPQKVIKRP INHFLAMFYD
     LSNSRRFEIA IFVLIFLNML TMGIEHYDQP HAVFFILEVS NAFFTTVFGL EAIVKIVGLR
     YHYFTVPWNV FDFLLVLASI FGILMEDIMI DLPISPTLLR VVRVFRIGRI LRLIKAAKGI
     RKLLFALVVS LPALFNIGAL LGLITFIYAI LGMSLFGHVK LQGALDDMVN FQTFGRSMQL
     LFRLMTSAGW NDVLESLMIQ PPVCDPFFNR QTNGDCGHPL LAITYFTSFI IISYMIVINM
     YIAIILENFN QAHQEEEIGI VEDDLEMFYI RWSKYDPHAT QFIHFSQLSD FIASLDPPLG
     ISKPNNVALV SFNLPISKGN KIHCLDILHA LVKHVLGHVE ETDNFKQLQE QMDVKFKKQF
     PTRKELEIVS STRIWKRQEK AAKTIQSDWK DYLRRKLEKE RSNSGDSATQ TSSPGGWQSK
     LSALNFFHLQ VSRRGTACSS RASSRKSSRA SDGSDLSELA GPWLNLPLML VSGADDVVKD
     IKQQSDELGK RGSIFVEAPR ANRRRSFYNF FLRHQDAVDD SLTSPSVHRK TAMNTNNTTT
     STSTSASASA SVSASATNVE CDKQTQHQHQ QPVAPTPTRK RASSFIRKKP PLERGLSAQS
     ALRVNKNAYV SEAPAPEVIV TKPSPEQQTH PHVHALGLRP DNATLVHVLV HRESEEYKEE
     DECSLSSPGH GSTNGNGHEK PKPPQIRIST GSSESAMDSS LMPTVQIMVD SPKEPPRGDF
     STDSGYPNVA YTPPQPPTID VDAPIDVNVQ GDTSQVFYDY NPESNIDNTN DIVPLEEQPQ
     APPDAENKQR
//
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