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Database: UniProt
Entry: B4MJ96_DROWI
LinkDB: B4MJ96_DROWI
Original site: B4MJ96_DROWI 
ID   B4MJ96_DROWI            Unreviewed;      1125 AA.
AC   B4MJ96;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   27-SEP-2017, entry version 67.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW72185.2};
GN   Name=Dwil\GK10270 {ECO:0000313|EMBL:EDW72185.2};
GN   ORFNames=Dwil_GK10270 {ECO:0000313|EMBL:EDW72185.2}, GK10270
GN   {ECO:0000313|FlyBase:FBgn0212285};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW72185.2, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW72185.2, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
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DR   EMBL; CH963738; EDW72185.2; -; Genomic_DNA.
DR   RefSeq; XP_002061199.2; XM_002061163.2.
DR   STRING; 7260.FBpp0239413; -.
DR   GeneID; 6638073; -.
DR   KEGG; dwi:Dwil_GK10270; -.
DR   FlyBase; FBgn0212285; Dwil\GK10270.
DR   eggNOG; KOG3676; Eukaryota.
DR   eggNOG; ENOG4110DG4; LUCA.
DR   InParanoid; B4MJ96; -.
DR   KO; K04975; -.
DR   OrthoDB; EOG091G0250; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0007628; P:adult walking behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0007629; P:flight behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0048060; P:negative gravitaxis; IEA:EnsemblMetazoa.
DR   GO; GO:0050884; P:neuromuscular process controlling posture; IEA:EnsemblMetazoa.
DR   GO; GO:0010996; P:response to auditory stimulus; IEA:EnsemblMetazoa.
DR   GO; GO:0009408; P:response to heat; IEA:EnsemblMetazoa.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:EnsemblMetazoa.
DR   GO; GO:0001964; P:startle response; IEA:EnsemblMetazoa.
DR   GO; GO:0040040; P:thermosensory behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0043052; P:thermotaxis; IEA:EnsemblMetazoa.
DR   CDD; cd00204; ANK; 2.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024862; TRPV.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00844120};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007798};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    508    527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    534    554       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    574    594       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    640    661       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      172    324       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      172    204       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      230    262       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   1125 AA;  124099 MW;  05D07A2BA7B4627E CRC64;
     MRFLLKKCLR KKAPEMKPGA ILDAVISQSS ATACKCLLYK LADYKRGGDL IDAINTGGLI
     AVEQLIREQF GVFMYNDGKG QMINRAEFLR WKYRDHTEVT IPIEASLSIH DPLGKWEDHK
     ACWQMQYRGA LGESLLHVLI ICDSKIHTKL ARVLLRVFPN LALDVMEGEE YLGASALHLS
     IAYSNNELVA DLIEAGADIN QRAIGSFFLP RDQQRMNPAK STDYEGLAYM GEYPLAWAAC
     CANESVYNLL VDCGSDPDAQ DSFGNMILHM VVVCDKLDMF GYALRHPKTP AKNGIVNQTG
     LTPLTLACKL GRAEVFREML ELSAREFWRY SNITCSGYPL NALDTLLPDG RTNWNSALFI
     ILNGTKPEHL DMLDGGIIQR LLEEKWKTFA QNQFLKRLLI LSTHLLCLSV SVYLRPAHDG
     EGEEDDGDGS TGATAAALQE AMGDGIAVAG AADSADVSYN AQTVARYCAE LATIAGVLSY
     VVFQQGDEIK NQGLSAFLKQ LSHAPAKAIF LFSNLLILAC IPFRLIGDTD TEEAILIFAV
     PGSWFLLMFF AGAIRLTGPF VTMIYSMITG DMFTFGIIYC IVLCGFSQAF YFLYKGHPQV
     QSTMFNTYTS TWMALFQTTL GDYNYPDLNQ TTYPNLSKTV FVIFMIFVPI LLLNMLIAMM
     GNTYVTVIEQ SEKEWMKQWA KIVVTLERAV PQADAKGYLE AYSIPLGPSD DSGFEVRGVM
     VIKSKSKTRA KQRKGAVSNW KRVGRVTLTA LKKRGMTGEE MRRLMWGRAS ISSPVKVTKQ
     KLKDPYNLHT DSDFTTAMDM LSFANNPASS TGVQLRSSTT AAQPMPPAPD PFRELIMMSD
     QRPETHDPHY FAGLQQLANK AFDLVEQTMK TQPSQEVAKK SALPTPPAAV GLQPAGTTTT
     PTGLVAPASV SDTAIPTPAL PMLGNLFQDP KDIVDPKKLE EFMSMLAEVD TEESDSGGPI
     LGKLSLAKRT HNALSKADIR REPNFNGVAG IGGGLEAGGV QSMSSVWAPP GIDLDAVASF
     DSAVAEEVLT IEQDAEVDSE DLPTAEQVHA TMKQFHLRKC QTSQDEAARR AKSARMRRKN
     KVSPEQSDAE FESDARRKQR SPPDPLEPWS TRELQDINKI LAKKS
//
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